ID A0A1S3RIR3_SALSA Unreviewed; 4875 AA.
AC A0A1S3RIR3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291};
DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969};
DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197};
DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030};
DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832};
GN Name=ryr1 {ECO:0000313|RefSeq:XP_014051742.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014051742.1};
RN [1] {ECO:0000313|RefSeq:XP_014051742.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014051742.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR RefSeq; XP_014051742.1; XM_014196267.1.
DR OrthoDB; 3144451at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 1.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 1.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50919; MIR; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000313|RefSeq:XP_014051742.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4145..4168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4386..4406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4480..4501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4615..4635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4675..4697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4756..4779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..103
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 361..571
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 787..983
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1120..1330
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1109..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1625..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3283..3309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4070..4110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4203..4360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1660..1704
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1705..1721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3295..3309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4072..4087
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4316..4350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4875 AA; 551615 MW; 9009534FCE46A11C CRC64;
MDECLAIPAA EQGDDQRRIA HYEGGAVCSH ARSLWRLEPL RIGWSGGHMK WGQSFRVRHI
TTGRYLCLDE EKGLLVVDPE KANAKMSAFC FRISKEKIEV AQKRDVEGMG TPEIKYGESM
CFVQHVSSGL WLTYASVDAK SARLGPLKRK AILHKEGHMD DALTVARSQT EEFQAARMIY
NTAGLFTQFI KALDSLSGKN KSSSGPPSLP MDSVALSLQD LIFYFRPPEE ELEHEEKQTK
LRSLKNRQNL FQEEGMITLV LDCIDRLNVY NTAAHFSEFA GEEAAESWKE IVNLLYELLA
SLIRGNRANC ALFCDNLDWL VSKLDRLEAS SGILEVLYCV LIESPEVLNI IQENHIKSII
SLLDKHGRNH KVLDVLCSLC VCNGVAVRSN QNLITENLLP GRDLLLQSNI INYVTSVRPN
IFLGTCEGST QYKKWYFEVM VDYVEPFLTA QAFHLRVGWA LTEGYSPYPG GGEGWGGNGV
GDDLYSYAFD GLHLWSGRVL RHVASPNMHI LAADDVVSCC LDLSVPSISF RINGHPVQGM
FENFNLDGLF FPVVSFSAGV RVRFLLGGRH GDFKFLPPPG YAPCYEAVLP KDRLRIEPIK
EYKHDFNGVR NLLGPTQSLS HTAFTPCPVD TVQIVLPPHL ERIREKLAEN SHELWAATRI
EQGWTYGSFR DDNKKLHPCL VDFQSLPEPE KNYNLAMSGE TLKTLLALGC HVGMGDEKAE
ENLKNIKMPK TYMMSSGYKP APLDLNHVKL TPNQTNLVER LAENGHNVWA RDRVHQGWTY
SIVQDIMSKR NPRLVPYNLL DEKTKKTNRD TVCAAVRTLI GYGYNIEPPD QESSGNGEGH
SRGNKIRVFR AEKSYAVTQG KWYFEFEAVT VGDMRVGWAR PSVRADTELG ADELAYVFNG
FKAQRWHVGN EPFGRSWLPG DVVGCMIDLV EQNIFFTLNG EMLISDSGSE MAFKDIDTGD
GFIPVCSLGL SQVGRLNLGQ NVSSLRYFTI CGLQEGFEPF AINMKRDITM WFSKSLPQFI
PVPTEHPHIE VSRVDGTVDS APCLKLTHKT FGSQNANTDL LFLRLSMPVE FHETFKVMAG
TTPLTRALTI PEDQVLEVDP DSDFEVLKKS ASRTEKEEEK KEPSVPKEIP VNEGGENVKD
ASTEKSKKKG FLFKAKKAAF TPPPVVPTMP RLMEEVVPDD RDDDDIILNT TTYYYSVRVI
AGQEPSGVWV GWITPDYHQY DLHFDLSKVR NVTVTVGDDK GNIHDSMKRS NCYMVWGGEF
SSSQQTRVSQ EDFVIGCLID LDTGLMTFTA NGKEINTFYQ VEPNTKLFPA VFVLPSSQNM
LQVELGKLKN IMPISAAMFR SERKNPVPQC PPRLDVQMLT PVIWSRMPNH FLSPETGRVN
ERHGWMVECR EPLTMMALHI PEENRCIDVL ELSERMDLLK FHYHTLKLYG SVCALGNNRV
AHALCSHVDE SQLFYAIENT YLPGPMRSGY YDLLISMHLE SAKRNRLMTN KEFIVPMTDE
TRSINLYSDT DNSHALPGVG LTTCLRPKLH FSPTGFVGTD LDIYTLSPFI PLQVLKAKAL
TMLTEAVQDG GQAMRDPVGG SVEFHFVPIL KLISTLLIMG VFENEDVKHI LKMIEPTVFS
GEAEAAAEEA EATAKGAGSQ TLALKEGGEE VKEEEEGAVE SGHETEMEDE GMGEEDEELE
AELEEPVEKE EEEEEEEEDG EKVDGEKGAE ETEKEATPGE ADGEAEEQVG LEEGLLHMKL
PESVKLQMCT LLQYFCDCEL RHRVEAIIAF SDQFVSQVQA NQRARYNELM LAFTMSAAET
ARKTREFRSP PQEQVNMLMN FKSIAEDEEC PVPDEVRDAL LSFHKNLLSH CGVHIEEEEV
EEELDMSLKG RLFRMLDKLR HLRKKKVEEE PEPVEETKPS TLQELISHTM IHWAQESFIQ
NPELVRLMFS LLHRQYDGLG ELIRALPKAY TINAISIKDT MDLLECLGQI RSLLIVQMGP
EEERLMIQSI GNIMSNKVFY QHPNLMRALG MHETVMEVMV NVLGGGDSKE IRFPRMVTNC
CRFLCYFCRI SRQNQRSMFD HLSYLLQNSG IGLGMRGSTP LDVAAASCID NNELALALQE
QDLEKVVKYL AGCGLQSCPQ LLAKGYPDIG WNPCGGEKYL DFLRFAVFVN GESVEENANV
VVRLLIRRPE CFGPALRGEG GNGLLAAIEE AIKISEDPAR DGPTVKKDRR FPGMFPGGEE
QHEENKVHLG NAIMSFYSAL IDLLGRCAPE MHLIQAGKGE ALRIRAILRS LVPMEDLVGV
ISLSVQIPDF GKDNSVIEPK MSSSFVPDHK APMVLFLDRV YGIDNQDFLL HVLEVGFLPD
MRAAASLDTA AFCTTEMALA LNRYLSLAVL PLITKCAFLF AGTDHRAIMI DSMLHTIYRL
SRGRAFTKAQ RDVIEECLMA LCKNLRPSML QHLLRRLVFD VPILNEYAKM PLKLLTNHYE
RCWKYYCLPN GWGNFGVSSE EELHLTRKLF WGIFESLAHK KFDAELFKIA MPCICAIAGA
IPPDYVDASY SSKTEKKALV DAEGNFDPKP VETTNTIIPE RLDGFINRYA EYTHDKWAFE
KIQNNWTYGE MLDENSKTHP MLRPYKTFSE KDKEIYRWPI KESMKAMIAW EWTLDQTREG
DEAKAELKKA ARKISQTAQA TYDPSHGYSP QPIEISHMAL SRELQSMAEQ LAENYHNTWG
RKKKMELQSK GGGAHPLLVP YDTLTAKEKA RDREKAHELL KFLQLNGFAV TRGMKDMESD
ISSIEKRFAY GFLQKLLKWM EIAQEFIAHL EAVVSSGRVE KSPHEQEIKF FAKILLPLIN
QYFKNHCLYF LSTPAKVLGS GGHSSNKEKE MIASIFCKMA ALVRHRVSLF GNDAAAIVNC
LHILARSLDA RTVMKSGPEI VKAGLRSFFE GAADDIEKMV ENLKLGKVSK GNQQVKGVSQ
NINYTTIALL PVLTSLFDHI SQHQFGDDVM LDDLQMSCYR IMCAIYSLGS VKNPHVERQR
PALGECLAHL AAAMPVAYLE PHLNEYNAFS VYTTKTPRER AILGLPNEVQ ELCQDIPELD
VLLKEIGDLA ESGARYTEMP HVIEITLPML CNYLPRWWER GVENFPELEG QICTDVTSDQ
LNQLLGSIMK IVVNNLGIDE ASWMKRLAVF SQPIVSRARP EMLKSHFIPT MEKLKKRTGK
VVAEEDHLRM EGKAEGDEEE GTIRDEFAVL CRDLYALYPL LIRYVDNNRA RWLTCPDPDA
EELFRMVGEV FIFWSKSHNF KREEQNFVVM NEINNMSFLT ADSKSKMSKG SDSEAGGSDV
ERTKKKRRGD RYSVQTSLIV AALKKMLPIG LNMCSPADHE LINLAKIRYS LRDTDEEVRE
FLQNNLHLQG KVENPSMRWQ MSLYKEMAGK AEDADAPEKV VKRVQEVSAV LYHIEVTEHP
FKSKKMVWHK LLSKQRRKAV VACFRMTPLY NLPRHRASNM FLEGYKRNWI HTEGYSFEDR
MIDDLSKAME QEGEEEEETE TKPDPLHQLI LHFSRTALTE KSKLDTDYLY MAYADIMAKS
CHIGEEDEGG EEVEEGAEDE MSFEVRQTEL EKEMEKQRLL YQQSRLHNRG AAEMVLQMIS
ACKGETGCMV SSTLKLGISI LNGGNVEVQQ KMLEYLKDKK DVGFFLSVQA LMQTCSVLDL
NAFERQNKAE GLGMVSEEGT NMKSERGEKV MADDEFTCDL FRMLQLLCEG HNNDFQNYLR
TQTGSTTTIN IIICTVDYLL RLQESISDFY WYYSGKDIID EPGKKNFSKA MTVAKQIFNS
LTEYIQGPCT GNQQSLTHSR LWDAVVGFLH VFAHMMMKLA QGKDSSQIGL LKELLDLQKD
MVVMLLSLLE GNVVNGTIAR QMVDMLVESS SNVEMILKFF DMFLKLKDIV ASDAFRDYVT
DPRGLISKKD FQKAMDSQKQ YSPSEIQFLL SCSEADENDM INFEEFADRF QEPAKDIGFN
IAVLLTNLSE HVPHDLRLKN FLEQAESVLN YFRPFLGRIE IMGASRKIER IYFEISEVNR
TQWEMPQVRE SKRQFIFDVV NEGGESEKME MFVNFCEDTI FEMNIASQIS EQEEEKEEED
DDEPAEGGAE AGGGGGGDEE GNGEEGEPES SSAFADFINS LLNFLSIFTF RNLRRQYRRV
RKMTIKQIVV GLATFFWTIL IGILHFIYSV CKGFFLLIWQ TLFGGGLVEG AKNITVTEIL
ASMPDPTQDE VHGDLPGEPR TGEEQEAGGV TDQMDTGGGE EEEEDNQDKE GGGPPRIDAP
GGLGDMGIEA TVEPPTPEGT PLTRRKQQPE EGAAAAADGQ AAEPAPAPAP AIEEPPPEPE
KADTENGEKA EKEAETKEEE KQEQPKEKKA KDKKNKKQHR EQGFQLWTEL DIQRNKFLNY
LSRNFYNLRF LALFIAFALN FILLFYKVSD SPPGEGDEVE GSGMFEGSGV GALFEGSGLF
EGSAEEMEGS GGDEGGDEEE EEGPVYFFLE ESTGYMQPTL TFLAALHTVI AFLCIIGYNC
LKIPLVIFKR EKELARKLEF DGLYITEQPE DDDIKGQWDR LVLNTPSFPN NYWDKFVKRK
VLDKYGDIYG RERIAELLGM DLASLDVSQQ TDKKPEEPDN STLAWCTSID FKYQIWKCGV
VFTDGTFLYL CWYTIMSLLG HYNNFFYACH LLDIAIGVKD LRTILSSVTH NGKQLMMTLG
LLAVVVYLYT VVAFIFFRKF YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE
DPAGDVYELY RVVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE DMETKCFICG
IGSDYFDTTP HGFETHTLEE HNLANYMFFL MYLINKDETE HTGQESYVWK MYQERAWDFF
PAGDCFRKQY EDQLA
//