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Database: UniProt
Entry: A0A1S3RIT2_SALSA
LinkDB: A0A1S3RIT2_SALSA
Original site: A0A1S3RIT2_SALSA 
ID   A0A1S3RIT2_SALSA        Unreviewed;      5104 AA.
AC   A0A1S3RIT2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   SubName: Full=ryanodine receptor 1 isoform X3 {ECO:0000313|RefSeq:XP_014051734.1};
GN   Name=ryr1 {ECO:0000313|RefSeq:XP_014051734.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014051734.1};
RN   [1] {ECO:0000313|RefSeq:XP_014051734.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014051734.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
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DR   RefSeq; XP_014051734.1; XM_014196259.1.
DR   GeneID; 106603084; -.
DR   CTD; 6261; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_014051734.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4374   4397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4615   4635       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4709   4730       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4844   4864       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4904   4926       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4985   5008       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    159       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      166    211       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      219    274       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      595    805       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1021   1217       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1354   1564       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      468    488       {ECO:0000256|SAM:Coils}.
FT   COILED     3711   3731       {ECO:0000256|SAM:Coils}.
FT   COILED     4551   4571       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5104 AA;  576987 MW;  4A2D37FD8DD27845 CRC64;
     MAEGGDGEEE IQFLRTDDQV VLQCTASILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLSNTMELNE AVDLDKWSSQ GGGHRTLLYG HAILLKHTHS
     SMYLSCLTTS RSLTDKLAFD VGLQEDSTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV
     SSERYLHLSY ASGDLMVDAS FMQTLWTMSP VMSGCELAEG FLTGGYVLRL FHGHMDECLA
     IPAAEQGDDQ RRIAHYEGGA VCSHARSLWR LEPLRIGWSG GHMKWGQSFR VRHITTGRYL
     CLDEEKGLLV VDPEKANAKM SAFCFRISKE KIEVAQKRDV EGMGTPEIKY GESMCFVQHV
     SSGLWLTYAS VDAKSARLGP LKRKAILHKE GHMDDALTVA RSQTEEFQAA RMIYNTAGLF
     TQFIKALDSL SGKNKSSSGP PSLPMDSVAL SLQDLIFYFR PPEEELEHEE KQTKLRSLKN
     RQNLFQEEGM ITLVLDCIDR LNVYNTAAHF SEFAGEEAAE SWKEIVNLLY ELLASLIRGN
     RANCALFCDN LDWLVSKLDR LEASSGILEV LYCVLIESPE VLNIIQENHI KSIISLLDKH
     GRNHKVLDVL CSLCVCNGVA VRSNQNLITE NLLPGRDLLL QSNIINYVTS VRPNIFLGTC
     EGSTQYKKWY FEVMVDYVEP FLTAQAFHLR VGWALTEGYS PYPGGGEGWG GNGVGDDLYS
     YAFDGLHLWS GRVLRHVASP NMHILAADDV VSCCLDLSVP SISFRINGHP VQGMFENFNL
     DGLFFPVVSF SAGVRVRFLL GGRHGDFKFL PPPGYAPCYE AVLPKDRLRI EPIKEYKHDF
     NGVRNLLGPT QSLSHTAFTP CPVDTVQIVL PPHLERIREK LAENSHELWA ATRIEQGWTY
     GSFRDDNKKL HPCLVDFQSL PEPEKNYNLA MSGETLKTLL ALGCHVGMGD EKAEENLKNI
     KMPKTYMMSS GYKPAPLDLN HVKLTPNQTN LVERLAENGH NVWARDRVHQ GWTYSIVQDI
     MSKRNPRLVP YNLLDEKTKK TNRDTVCAAV RTLIGYGYNI EPPDQESSGN GEGHSRGNKI
     RVFRAEKSYA VTQGKWYFEF EAVTVGDMRV GWARPSVRAD TELGADELAY VFNGFKAQRW
     HVGNEPFGRS WLPGDVVGCM IDLVEQNIFF TLNGEMLISD SGSEMAFKDI DTGDGFIPVC
     SLGLSQVGRL NLGQNVSSLR YFTICGLQEG FEPFAINMKR DITMWFSKSL PQFIPVPTEH
     PHIEVSRVDG TVDSAPCLKL THKTFGSQNA NTDLLFLRLS MPVEFHETFK VMAGTTPLTR
     ALTIPEDQVL EVDPDSDFEV LKKSASRTEK EEEKKEPSVP KEIPVNEGGE NVKDASTEKS
     KKKGFLFKAK KAAFTPPPVV PTMPRLMEEV VPDDRDDDDI ILNTTTYYYS VRVIAGQEPS
     GVWVGWITPD YHQYDLHFDL SKVRNVTVTV GDDKGNIHDS MKRSNCYMVW GGEFSSSQQT
     RVSQEDFVIG CLIDLDTGLM TFTANGKEIN TFYQVEPNTK LFPAVFVLPS SQNMLQVELG
     KLKNIMPISA AMFRSERKNP VPQCPPRLDV QMLTPVIWSR MPNHFLSPET GRVNERHGWM
     VECREPLTMM ALHIPEENRC IDVLELSERM DLLKFHYHTL KLYGSVCALG NNRVAHALCS
     HVDESQLFYA IENTYLPGPM RSGYYDLLIS MHLESAKRNR LMTNKEFIVP MTDETRSINL
     YSDTDNSHAL PGVGLTTCLR PKLHFSPTGF VGTDLDIYTL SPFIPLQVLK AKALTMLTEA
     VQDGGQAMRD PVGGSVEFHF VPILKLISTL LIMGVFENED VKHILKMIEP TVFSGEAEAA
     AEEAEATAKG AGSQTLALKE GGEEVKEEEE GAVESGHETE MEDEGMGEED EELEAELEEP
     VEKEEEEEEE EEDGEKVDGE KGAEETEKEA TPGEADGEAE EQVGLEEGLL HMKLPESVKL
     QMCTLLQYFC DCELRHRVEA IIAFSDQFVS QVQANQRARY NELMLAFTMS AAETARKTRE
     FRSPPQEQVN MLMNFKSIAE DEECPVPDEV RDALLSFHKN LLSHCGVHIE EEEVEEELDM
     SLKGRLFRML DKLRHLRKKK VEEEPEPVEE TKPSTLQELI SHTMIHWAQE SFIQNPELVR
     LMFSLLHRQY DGLGELIRAL PKAYTINAIS IKDTMDLLEC LGQIRSLLIV QMGPEEERLM
     IQSIGNIMSN KVFYQHPNLM RALGMHETVM EVMVNVLGGG DSKEIRFPRM VTNCCRFLCY
     FCRISRQNQR SMFDHLSYLL QNSGIGLGMR GSTPLDVAAA SCIDNNELAL ALQEQDLEKV
     VKYLAGCGLQ SCPQLLAKGY PDIGWNPCGG EKYLDFLRFA VFVNGESVEE NANVVVRLLI
     RRPECFGPAL RGEGGNGLLA AIEEAIKISE DPARDGPTVK KDRRFPGMFP GGEEQHEENK
     VHLGNAIMSF YSALIDLLGR CAPEMHLIQA GKGEALRIRA ILRSLVPMED LVGVISLSVQ
     IPDFGKDNSV IEPKMSSSFV PDHKAPMVLF LDRVYGIDNQ DFLLHVLEVG FLPDMRAAAS
     LDTAAFCTTE MALALNRYLS LAVLPLITKC AFLFAGTDHR AIMIDSMLHT IYRLSRGRAF
     TKAQRDVIEE CLMALCKNLR PSMLQHLLRR LVFDVPILNE YAKMPLKLLT NHYERCWKYY
     CLPNGWGNFG VSSEEELHLT RKLFWGIFES LAHKKFDAEL FKIAMPCICA IAGAIPPDYV
     DASYSSKTEK KALVDAEGNF DPKPVETTNT IIPERLDGFI NRYAEYTHDK WAFEKIQNNW
     TYGEMLDENS KTHPMLRPYK TFSEKDKEIY RWPIKESMKA MIAWEWTLDQ TREGDEAKAE
     LKKAARKISQ TAQATYDPSH GYSPQPIEIS HMALSRELQS MAEQLAENYH NTWGRKKKME
     LQSKGGGAHP LLVPYDTLTA KEKARDREKA HELLKFLQLN GFAVTRGMKD MESDISSIEK
     RFAYGFLQKL LKWMEIAQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL PLINQYFKNH
     CLYFLSTPAK VLGSGGHSSN KEKEMIASIF CKMAALVRHR VSLFGNDAAA IVNCLHILAR
     SLDARTVMKS GPEIVKAGLR SFFEGAADDI EKMVENLKLG KVSKGNQQVK GVSQNINYTT
     IALLPVLTSL FDHISQHQFG DDVMLDDLQM SCYRIMCAIY SLGSVKNPHV ERQRPALGEC
     LAHLAAAMPV AYLEPHLNEY NAFSVYTTKT PRERAILGLP NEVQELCQDI PELDVLLKEI
     GDLAESGARY TEMPHVIEIT LPMLCNYLPR WWERGVENFP ELEGQICTDV TSDQLNQLLG
     SIMKIVVNNL GIDEASWMKR LAVFSQPIVS RARPEMLKSH FIPTMEKLKK RTGKVVAEED
     HLRMEGKAEG DEEEGTIRDE FAVLCRDLYA LYPLLIRYVD NNRARWLTCP DPDAEELFRM
     VGEVFIFWSK SHNFKREEQN FVVMNEINNM SFLTADSKSK MSKAGGSDVE RTKKKRRGDR
     YSVQTSLIVA ALKKMLPIGL NMCSPADHEL INLAKIRYSL RDTDEEVREF LQNNLHLQGK
     VENPSMRWQM SLYKEMAGKA EDADAPEKVV KRVQEVSAVL YHIEVTEHPF KSKKMVWHKL
     LSKQRRKAVV ACFRMTPLYN LPRHRASNMF LEGYKRNWIH TEGYSFEDRM IDDLSKAMEQ
     EGEEEEETET KPDPLHQLIL HFSRTALTEK SKLDTDYLYM AYADIMAKSC HIGEEDEGGE
     EVEEGAEDEM SFEVRQTELE KEMEKQRLLY QQSRLHNRGA AEMVLQMISA CKGETGCMVS
     STLKLGISIL NGGNVEVQQK MLEYLKDKKD VGFFLSVQAL MQTCSVLDLN AFERQNKAEG
     LGMVSEEGTN MKSERGEKVM ADDEFTCDLF RMLQLLCEGH NNDFQNYLRT QTGSTTTINI
     IICTVDYLLR LQESISDFYW YYSGKDIIDE PGKKNFSKAM TVAKQIFNSL TEYIQGPCTG
     NQQSLTHSRL WDAVVGFLHV FAHMMMKLAQ GKDSSQIGLL KELLDLQKDM VVMLLSLLEG
     NVVNGTIARQ MVDMLVESSS NVEMILKFFD MFLKLKDIVA SDAFRDYVTD PRGLISKKDF
     QKAMDSQKQY SPSEIQFLLS CSEADENDMI NFEEFADRFQ EPAKDIGFNI AVLLTNLSEH
     VPHDLRLKNF LEQAESVLNY FRPFLGRIEI MGASRKIERI YFEISEVNRT QWEMPQVRES
     KRQFIFDVVN EGGESEKMEM FVNFCEDTIF EMNIASQISE QEEEKEEEDD DEPAEGGAEA
     GGGGGGDEEG NGEEGEPESS SAFADFINSL LNFLSIFTFR NLRRQYRRVR KMTIKQIVVG
     LATFFWTILI GILHFIYSVC KGFFLLIWQT LFGGGLVEGA KNITVTEILA SMPDPTQDEV
     HGDLPGEPRT GEEQEAGGVT DQMDTGGGEE EEEDNQDKEG GGPPRIDAPG GLGDMGIEAT
     VEPPTPEGTP LTRRKQQPEE GAAAAADGQA AEPAPAPAPA IEEPPPEPEK ADTENGEKAE
     KEAETKEEEK QEQPKEKKAK DKKNKKQHRE QGFQLWTELD IQRNKFLNYL SRNFYNLRFL
     ALFIAFALNF ILLFYKVSDS PPGEGDEVEG SGMFEGSGVG ALFEGSGLFE GSAEEMEGSG
     GDEGGDEEEE EGPVYFFLEE STGYMQPTLT FLAALHTVIA FLCIIGYNCL KIPLVIFKRE
     KELARKLEFD GLYITEQPED DDIKGQWDRL VLNTPSFPNN YWDKFVKRKV LDKYGDIYGR
     ERIAELLGMD LASLDVSQQT DKKPEEPDNS TLAWCTSIDF KYQIWKCGVV FTDGTFLYLC
     WYTIMSLLGH YNNFFYACHL LDIAIGVKDL RTILSSVTHN GKQLMMTLGL LAVVVYLYTV
     VAFIFFRKFY NKSEDEDEPD MKCDDMMTCY LFHMYVGVRA GGGIGDEIED PAGDVYELYR
     VVFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVKED METKCFICGI GSDYFDTTPH
     GFETHTLEEH NLANYMFFLM YLINKDETEH TGQESYVWKM YQERAWDFFP AGDCFRKQYE
     DQLA
//
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