ID A0A1S3RIT4_SALSA Unreviewed; 5098 AA.
AC A0A1S3RIT4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291};
DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969};
DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197};
DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030};
DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832};
GN Name=ryr1 {ECO:0000313|RefSeq:XP_014051739.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014051739.1};
RN [1] {ECO:0000313|RefSeq:XP_014051739.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014051739.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR RefSeq; XP_014051739.1; XM_014196264.1.
DR GeneID; 106603084; -.
DR CTD; 798565; -.
DR OrthoDB; 3144451at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000313|RefSeq:XP_014051739.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4368..4391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4609..4629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4703..4724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4838..4858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4898..4920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4979..5002
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..159
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 166..211
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 219..274
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 280..337
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 595..805
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1021..1217
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1354..1564
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1343..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1859..1960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3518..3537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4293..4333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4426..4583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1343..1361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1894..1938
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1939..1955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3523..3537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4295..4310
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4539..4573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5098 AA; 576260 MW; 016C964006078B0C CRC64;
MAEGGDGEEE IQFLRTDDQV VLQCTASILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
DLAICCFILE QSLSVRALQE MLSNTMELNE AVDLDKWSSQ GGGHRTLLYG HAILLKHTHS
SMYLSCLTTS RSLTDKLAFD VGLQEDSTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV
SSERYLHLSY ASGDLMVDAS FMQTLWTMSP VMSGCELAEG FLTGGYVLRL FHGHMDECLA
IPAAEQGDDQ RRIAHYEGGA VCSHARSLWR LEPLRIGWSG GHMKWGQSFR VRHITTGRYL
CLDEEKGLLV VDPEKANAKM SAFCFRISKE KIEVAQKRDV EGMGTPEIKY GESMCFVQHV
SSGLWLTYAS VDAKSARLGP LKRKAILHKE GHMDDALTVA RSQTEEFQAA RMIYNTAGLF
TQFIKALDSL SGKNKSSSGP PSLPMDSVAL SLQDLIFYFR PPEEELEHEE KQTKLRSLKN
RQNLFQEEGM ITLVLDCIDR LNVYNTAAHF SEFAGEEAAE SWKEIVNLLY ELLASLIRGN
RANCALFCDN LDWLVSKLDR LEASSGILEV LYCVLIESPE VLNIIQENHI KSIISLLDKH
GRNHKVLDVL CSLCVCNGVA VRSNQNLITE NLLPGRDLLL QSNIINYVTS VRPNIFLGTC
EGSTQYKKWY FEVMVDYVEP FLTAQAFHLR VGWALTEGYS PYPGGGEGWG GNGVGDDLYS
YAFDGLHLWS GRVLRHVASP NMHILAADDV VSCCLDLSVP SISFRINGHP VQGMFENFNL
DGLFFPVVSF SAGVRVRFLL GGRHGDFKFL PPPGYAPCYE AVLPKDRLRI EPIKEYKHDF
NGVRNLLGPT QSLSHTAFTP CPVDTVQIVL PPHLERIREK LAENSHELWA ATRIEQGWTY
GSFRDDNKKL HPCLVDFQSL PEPEKNYNLA MSGETLKTLL ALGCHVGMGD EKAEENLKNI
KMPKTYMMSS GYKPAPLDLN HVKLTPNQTN LVERLAENGH NVWARDRVHQ GWTYSIVQDI
MSKRNPRLVP YNLLDEKTKK TNRDTVCAAV RTLIGYGYNI EPPDQESSGN GEGHSRGNKI
RVFRAEKSYA VTQGKWYFEF EAVTVGDMRV GWARPSVRAD TELGADELAY VFNGFKAQRW
HVGNEPFGRS WLPGDVVGCM IDLVEQNIFF TLNGEMLISD SGSEMAFKDI DTGDGFIPVC
SLGLSQVGRL NLGQNVSSLR YFTICGLQEG FEPFAINMKR DITMWFSKSL PQFIPVPTEH
PHIEVSRVDG TVDSAPCLKL THKTFGSQNA NTDLLFLRLS MPVEFHETFK VMAGTTPLTR
ALTIPEDQVL EVDPDSDFEV LKKSASRTEK EEEKKEPSVP KEIPVNEGGE NVKDASTEKS
KKKGFLFKAK KAAFTPPPVV PTMPRLMEEV VPDDRDDDDI ILNTTTYYYS VRVIAGQEPS
GVWVGWITPD YHQYDLHFDL SKVRNVTVTV GDDKGNIHDS MKRSNCYMVW GGEFSSSQQT
RVSQEDFVIG CLIDLDTGLM TFTANGKEIN TFYQVEPNTK LFPAVFVLPS SQNMLQVELG
KLKNIMPISA AMFRSERKNP VPQCPPRLDV QMLTPVIWSR MPNHFLSPET GRVNERHGWM
VECREPLTMM ALHIPEENRC IDVLELSERM DLLKFHYHTL KLYGSVCALG NNRVAHALCS
HVDESQLFYA IENTYLPGPM RSGYYDLLIS MHLESAKRNR LMTNKEFIVP MTDETRSINL
YSDTDNSHAL PGVGLTTCLR PKLHFSPTGF VGTDLDIYTL SPFIPLQVLK AKALTMLTEA
VQDGGQAMRD PVGGSVEFHF VPILKLISTL LIMGVFENED VKHILKMIEP TVFSGEAEAA
AEEAEATAKG AGSQTLALKE GGEEVKEEEE GAVESGHETE MEDEGMGEED EELEAELEEP
VEKEEEEEEE EEDGEKVDGE KGAEETEKEA TPGEADGEAE EQVGLEEGLL HMKLPESVKL
QMCTLLQYFC DCELRHRVEA IIAFSDQFVS QVQANQRARY NELMLAFTMS AAETARKTRE
FRSPPQEQVN MLMNFKSIAE DEECPVPDEV RDALLSFHKN LLSHCGVHIE EEEVEEELDM
SLKGRLFRML DKLRHLRKKK VEEEPEPVEE TKPSTLQELI SHTMIHWAQE SFIQNPELVR
LMFSLLHRQY DGLGELIRAL PKAYTINAIS IKDTMDLLEC LGQIRSLLIV QMGPEEERLM
IQSIGNIMSN KVFYQHPNLM RALGMHETVM EVMVNVLGGG DSKEIRFPRM VTNCCRFLCY
FCRISRQNQR SMFDHLSYLL QNSGIGLGMR GSTPLDVAAA SCIDNNELAL ALQEQDLEKV
VKYLAGCGLQ SCPQLLAKGY PDIGWNPCGG EKYLDFLRFA VFVNGESVEE NANVVVRLLI
RRPECFGPAL RGEGGNGLLA AIEEAIKISE DPARDGPTVK KDRRFPGMFP GGEEQHEENK
VHLGNAIMSF YSALIDLLGR CAPEMHLIQA GKGEALRIRA ILRSLVPMED LVGVISLSVQ
IPDFGKDNSV IEPKMSSSFV PDHKAPMVLF LDRVYGIDNQ DFLLHVLEVG FLPDMRAAAS
LDTAAFCTTE MALALNRYLS LAVLPLITKC AFLFAGTDHR AIMIDSMLHT IYRLSRGRAF
TKAQRDVIEE CLMALCKNLR PSMLQHLLRR LVFDVPILNE YAKMPLKLLT NHYERCWKYY
CLPNGWGNFG VSSEEELHLT RKLFWGIFES LAHKKFDAEL FKIAMPCICA IAGAIPPDYV
DASYSSKTEK KALVDAEGNF DPKPVETTNT IIPERLDGFI NRYAEYTHDK WAFEKIQNNW
TYGEMLDENS KTHPMLRPYK TFSEKDKEIY RWPIKESMKA MIAWEWTLDQ TREGDEAKAE
LKKAARKISQ TAQATYDPSH GYSPQPIEIS HMALSRELQS MAEQLAENYH NTWGRKKKME
LQSKGGGAHP LLVPYDTLTA KEKARDREKA HELLKFLQLN GFAVTRGMKD MESDISSIEK
RFAYGFLQKL LKWMEIAQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL PLINQYFKNH
CLYFLSTPAK VLGSGGHSSN KEKEMIASIF CKMAALVRHR VSLFGNDAAA IVNCLHILAR
SLDARTVMKS GPEIVKAGLR SFFEGAADDI EKMVENLKLG KVSKGNQQVK GVSQNINYTT
IALLPVLTSL FDHISQHQFG DDVMLDDLQM SCYRIMCAIY SLGSVKNPHV ERQRPALGEC
LAHLAAAMPV AYLEPHLNEY NAFSVYTTKT PRERAILGLP NEVQELCQDI PELDVLLKEI
GDLAESGARY TEMPHVIEIT LPMLCNYLPR WWERGVENFP ELEGQICTDV TSDQLNQLLG
SIMKIVVNNL GIDEASWMKR LAVFSQPIVS RARPEMLKSH FIPTMEKLKK RTGKVVAEED
HLRMEGKAEG DEEEGTIRDE FAVLCRDLYA LYPLLIRYVD NNRARWLTCP DPDAEELFRM
VGEVFIFWSK SHNFKREEQN FVVMNEINNM SFLTADSKSK MSKAGGSDVE RTKKKRRGDR
YSVQTSLIVA ALKKMLPIGL NMCSPADHEL INLAKIRYSL RDTDEEVREF LQNNLHLQGK
VENPSMRWQM SLYKEMAGKA EDADAPEKVV KRVQEVSAVL YHIEVTEHPF KSKKMVWHKL
LSKQRRKAVV ACFRMTPLYN LPRHRASNMF LEGYKRNWIH TEGYSFEDRM IDDLSKAMEQ
EGEEEEETET KPDPLHQLIL HFSRTALTEK SKLDTDYLYM AYADIMAKSC HIGEEDEGGE
EVEEGAEDEM SFEEKEMEKQ RLLYQQSRLH NRGAAEMVLQ MISACKGETG CMVSSTLKLG
ISILNGGNVE VQQKMLEYLK DKKDVGFFLS VQALMQTCSV LDLNAFERQN KAEGLGMVSE
EGTNMKSERG EKVMADDEFT CDLFRMLQLL CEGHNNDFQN YLRTQTGSTT TINIIICTVD
YLLRLQESIS DFYWYYSGKD IIDEPGKKNF SKAMTVAKQI FNSLTEYIQG PCTGNQQSLT
HSRLWDAVVG FLHVFAHMMM KLAQGKDSSQ IGLLKELLDL QKDMVVMLLS LLEGNVVNGT
IARQMVDMLV ESSSNVEMIL KFFDMFLKLK DIVASDAFRD YVTDPRGLIS KKDFQKAMDS
QKQYSPSEIQ FLLSCSEADE NDMINFEEFA DRFQEPAKDI GFNIAVLLTN LSEHVPHDLR
LKNFLEQAES VLNYFRPFLG RIEIMGASRK IERIYFEISE VNRTQWEMPQ VRESKRQFIF
DVVNEGGESE KMEMFVNFCE DTIFEMNIAS QISEQEEEKE EEDDDEPAEG GAEAGGGGGG
DEEGNGEEGE PESSSAFADF INSLLNFLSI FTFRNLRRQY RRVRKMTIKQ IVVGLATFFW
TILIGILHFI YSVCKGFFLL IWQTLFGGGL VEGAKNITVT EILASMPDPT QDEVHGDLPG
EPRTGEEQEA GGVTDQMDTG GGEEEEEDNQ DKEGGGPPRI DAPGGLGDMG IEATVEPPTP
EGTPLTRRKQ QPEEGAAAAA DGQAAEPAPA PAPAIEEPPP EPEKADTENG EKAEKEAETK
EEEKQEQPKE KKAKDKKNKK QHREQGFQLW TELDIQRNKF LNYLSRNFYN LRFLALFIAF
ALNFILLFYK VSDSPPGEGD EVEGSGMFEG SGVGALFEGS GLFEGSAEEM EGSGGDEGGD
EEEEEGPVYF FLEESTGYMQ PTLTFLAALH TVIAFLCIIG YNCLKIPLVI FKREKELARK
LEFDGLYITE QPEDDDIKGQ WDRLVLNTPS FPNNYWDKFV KRKVLDKYGD IYGRERIAEL
LGMDLASLDV SQQTDKKPEE PDNSTLAWCT SIDFKYQIWK CGVVFTDGTF LYLCWYTIMS
LLGHYNNFFY ACHLLDIAIG VKDLRTILSS VTHNGKQLMM TLGLLAVVVY LYTVVAFIFF
RKFYNKSEDE DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD EIEDPAGDVY ELYRVVFDIT
FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VKEDMETKCF ICGIGSDYFD TTPHGFETHT
LEEHNLANYM FFLMYLINKD ETEHTGQESY VWKMYQERAW DFFPAGDCFR KQYEDQLA
//
