ID A0A1S3RJ23_SALSA Unreviewed; 1276 AA.
AC A0A1S3RJ23;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 3-like isoform X2 {ECO:0000313|RefSeq:XP_014051837.1};
GN Name=LOC106603116 {ECO:0000313|RefSeq:XP_014051837.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014051837.1};
RN [1] {ECO:0000313|RefSeq:XP_014051837.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014051837.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_014051837.1; XM_014196362.1.
DR AlphaFoldDB; A0A1S3RJ23; -.
DR GeneID; 106603116; -.
DR OrthoDB; 354414at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 11.
DR Gene3D; 2.10.25.10; Laminin; 16.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 14.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 15.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 13.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1276
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010219224"
FT DOMAIN 79..111
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 218..261
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 295..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 342..394
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 492..528
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 534..577
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 578..620
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 661..701
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 702..742
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 743..782
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 783..825
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 835..889
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1047..1087
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1097..1150
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1219..1260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 193..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 83..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 101..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1276 AA; 141069 MW; AD9EE954AC358545 CRC64;
MPSLIISHLL VIWLGVQRLA WCAERTSTRE RFKVVIAPLI CKRICLKGQC QDTCEQGNNT
TLIGENGQSA DTLTGPGFRV VVCPLTCMNG GVCSSRTHCL CPPGFTGRLC QFPLRQMPEA
QAARGNKQPV YTLSVLPDGQ SQGEQTAMGR PQLTQTHSVF TLPLAQGAGH HSSEVQFNVR
VHHAHDTSVV IHPLDQSDSK PPHKTVTRLT PQTHKPRGRC FQETTPKQAC SSTPLPVLTN
QEDCCGSVGN SWGQNKCYKC PKLPYPGVKL QTIIEDYGST CPQGYKRLNS THCQDINECT
MHGVCQNGEC LNTQGSFLCA CKPGFTLDRT RCVESPSPVE QGQCFLIATE AGRCEHALPT
SLSQEMCCCT VGKAWGSNCE RCPQDGTASF SKICPAGKGY FLHSVRETVA FPPQIHSSLE
QVPLKPDKNQ KKDKVKHQEE PPETTTPMQL SPISTHGPRV PVIITKPTPP PIIRLNPGSD
PLEVAQTQVS PETDECRLNR NLCGHGECVN MHTGFKCECY AGYRLHPQRN ACVDDDECDT
EPCGHSRGIC INTEGSYRCR CLHGYKLLVY HGKLRCIDVN ECSKMDICGQ GGQCVNLPGS
YKCECHKGFR SKSQRQPACE DINECLDPNS CPNDQCENTP GSYECVPCLP GHQAQGGVCY
DVNECQKRGV CPNGRCENLP GTYRCLCNEG FLPAADSKGC RDIDECEDDR LCANGRCVNT
EGSFQCQCYP GYQRTQEGSH CEDINECERP SNCQRGRCIN SMGSYRCECQ KGYMLVGGRR
CQDIDECATD RGLCQPHGVC ENRQGSYVCV CKDGFILSED KHSCEEIEVA VEDKKECYLN
LDDTVFCDSV LATNVTKQEC CCSIGVGWGD HCEIYPCPVY HSSEFHSLCP VGRGFYHEEG
VTEYGLSVHR DIDECVLFSN EICKEGRCMN TQPGYECYCQ QGFYYDSNLL ECIDVNECHD
ESLCTNGQCK NTRGSYYCTC KSPWIYEASN KKCVIPTVAG VDECQDSLNC KNGHCVDTPG
SYYCICSPPW ILATDRNSCV TPEEQADINE CQDPSYCKNG RCVNTPGSFH CICTQPLTFS
AALKQCVYDD RTAAHKDVCF LQVDEDLICS HPRNGLVVTY SECCCHYGRG WGPECRTCPQ
RNSGIFNRLC EMHLETESDG EGDFLAAFAN YNPGIGDSSE EDSDECSCAN GRCVRSYLGT
MCECNTGFRL DHSRTRCTDI DECAEPGVRV NPCKNARCVN TIGSFKCYCK NGFVPARRPN
ICVPGTKAQH TRTRAL
//
