ID A0A1S3RJ76_SALSA Unreviewed; 1009 AA.
AC A0A1S3RJ76;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5-like isoform X2 {ECO:0000313|RefSeq:XP_014052325.1};
GN Name=LOC106603320 {ECO:0000313|RefSeq:XP_014052325.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014052325.1};
RN [1] {ECO:0000313|RefSeq:XP_014052325.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014052325.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
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DR RefSeq; XP_014052325.1; XM_014196850.1.
DR AlphaFoldDB; A0A1S3RJ76; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR CDD; cd00167; SANT; 2.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; SWI_SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 157..322
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 452..603
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 795..847
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 117792 MW; C1A2A712F6F9E1E6 CRC64;
MSDEEIPSTS REHLPEDEEA KDPPFQLKPP PKALPKAEGA VDPEYEEKRK TDRANRFEFL
LKQTELFAHF IQPASQKSPT SPLKVKLGRP RVKQDEKQNL LSVGDNRHRR TEQEEDEELL
SESRKAANVL VRFEESPSYV KNGELRDYQI RGLNWMISLY ENGINGILAD EMGLGKTLQT
IALLGYLKHY RNIPGPHMVL VPKSTLHNWM NEFKRWVPTL KAVCLIGDKD ARAAFIRDVM
MPGEWDVCVT SYEMVIREKS VFKKFNWRYL VIDEAHRIKN EKSKLSEIVR EFKTTNRLLL
TGTPLQNNLH ELWSLLNFLL PDVFNSANDF DSWFDTNNCL GDQKLVERLH AVLRPFLLRR
IKAEVEKNLP PKKEVKIYLG LSKMQREWYT RILMKDIDIL NSSGKTDKMR LLNILMQLRK
CCNHPYLFDG AEPGPPYTTD THLVTNSGKM VALDKLLPKV QEQGSRVLIF SQMTRVLDIL
EDYCMWRGYE YCRLDGNTPH EARQEAIEAY NADNSSKFIF MLSTRAGGLG INLATADVVI
LYDSDWNPQV DLQAMDRAHR IGQKKPVRVF RLITDNTVEE RIVERAEMKL RLDSIVIQQG
RLMEQSNKLG KDEMLQMIRH GATHVFASKD NELTDEDINT ILERGAKKTA EMNERMESLG
ESSLRNFTVD TGGAETSLYN FEGEDYREKQ KLSMMEWIEP PKRERKANYA VDAYFREALR
VSEPRAPKAP RPPKQPNIQD FQFFPPRLFE LLEMEILFYR NTIGYKVQKE EQRKIDEAGP
LSPEETEEKE KLLTQGFTSW NKRDFNQFIK ANEKYGRDDI DNIAREVEGK NPEEVIEYSA
IFWERCNELQ DIEKIMAQIE RGEARIQRRI SIKKALDAKV ARYKAPFHQL RIQYGTNKGK
NYTEEEDRFL ICMLHKMGFD KENVYEELRQ CVRNAPQFRF DWFIKSRTAM ELQRRCNTLI
SLIEKENMEI EEKERAEKKK RTPKSQTAHK RKADASSEGT GRKEKKSRA
//
