ID A0A1S3RJK5_SALSA Unreviewed; 1128 AA.
AC A0A1S3RJK5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like {ECO:0000313|RefSeq:XP_014052437.1, ECO:0000313|RefSeq:XP_014052438.1};
GN Name=LOC106603376 {ECO:0000313|RefSeq:XP_014052437.1,
GN ECO:0000313|RefSeq:XP_014052438.1, ECO:0000313|RefSeq:XP_014052440.1,
GN ECO:0000313|RefSeq:XP_014052441.1, ECO:0000313|RefSeq:XP_014052442.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014052438.1};
RN [1] {ECO:0000313|RefSeq:XP_014052437.1, ECO:0000313|RefSeq:XP_014052438.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014052437.1,
RC ECO:0000313|RefSeq:XP_014052438.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014052437.1; XM_014196962.1.
DR RefSeq; XP_014052438.1; XM_014196963.1.
DR RefSeq; XP_014052440.1; XM_014196965.1.
DR RefSeq; XP_014052441.1; XM_014196966.1.
DR RefSeq; XP_014052442.1; XM_014196967.1.
DR STRING; 8030.ENSSSAP00000062255; -.
DR GeneID; 106603376; -.
DR KEGG; sasa:106603376; -.
DR OrthoDB; 4835at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08837; ArfGap_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 3.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 4.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 63..155
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 181..270
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 276..383
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 479..586
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 697..874
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 925..995
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
SQ SEQUENCE 1128 AA; 128212 MW; 36285C9E36896D7A CRC64;
MADNEDALRA MQNCFHSQFS VDEAEYEDIE ENRRTSVDED SIYLGCTLSR SFNPEDSDFH
HSSVIKMGWL HKTPPKGTLV FQKRWVMLDA QYLRYFQNEK EVYSKRIIAI LSVTEVLNVG
GQKFEVVTRN RTFLFRAENN TVREEWVSVL KETIQQRRNS MEMPLMNFSD TSGQSARRVS
LISKQGFLEM SGLRSKLYVV ICADRVFLYR NAEEHSQGVG ITSIEMNLGT VKGTDKRSFN
LTTFYRKFRF VAESEQQREQ WVEALQACVS HSLSSNAVAQ KIWSEEANQR CADCGAPQPD
WASVNLCVVL CKCCAGVHRG LGQSVSKVRS LKMDEKVWTE NQLFLLLGNN KVNLFWAANI
PPSEMLCPSS DSEERQRFVT AKYCQGKYRR YHALFGQQEA LNKALCNTIQ TGDVLETLSL
VFSGADVNCY TGDPELPSPV SIAQHHGQTL QVEFLVHNHN TELPGSRAGE HTILEAALPV
SHTGYLFKIA SSTRAVTERK SKGDFSRRWC SLNQGTFSYY ESEKSSSQSG QMKMSDVLCL
VVNPQGKHGY SHSFELYHDS GRVYLFGEDS PDTVREWIKA IGKALVPPVA EDLVGWSFER
VGRLRYTAGQ SFHCPYLGWF SLGGSRLLLL LHGEDQVDNI DLRKLHELSV EQEAAAVVLV
DRGRRLRLEG DRRPDFQGWL SGIQQGLGRG DGPLDQQQLT ETEVPVIVDR CISYITQHGL
KSEGIYRRCG VNSKIAALLL SLRHDARQVR LSEGERQVDN VANVLKRFLR EVGEGVFNGH
QASLPWLHTT TVSERRERVS QYQALLHSLP PVNRATLGAV INHLYCVQCF ADENQMNMHN
LAIVFGPTVF QTDGTDNSAG QVVEELIQNY QDIFNVNAEQ LQRQLDMISH VIKAQEEHAE
EGNPSPLTIC GVYLERKEEG SELLVQISQA VSAEELVCEV LRRGNIPPQQ GDYWSCFLVN
DNQEMERPLH YQERALAIYF SLGKDCHLVV KRNCYMEAML IYIAGMVDVS RNSMIKFSDE
KGQRGKRTFC RRLCVLDGTS LRLYKQVKST QPERECQVHA LKVYYGIKKR LQPPSCWGMT
VVCEQAERDK QQWYLCCESK NELIEWLATF MNLQHNSDLW PAASRPDS
//
