ID A0A1S3RJW5_SALSA Unreviewed; 342 AA.
AC A0A1S3RJW5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ion channel TACAN {ECO:0000256|ARBA:ARBA00039635};
DE AltName: Full=Transmembrane protein 120A {ECO:0000256|ARBA:ARBA00041456};
GN Name=t120a {ECO:0000313|RefSeq:XP_014052556.1,
GN ECO:0000313|RefSeq:XP_014052557.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014052556.1};
RN [1] {ECO:0000313|RefSeq:XP_014052556.1, ECO:0000313|RefSeq:XP_014052557.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014052556.1,
RC ECO:0000313|RefSeq:XP_014052557.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004473}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004473}.
CC -!- SIMILARITY: Belongs to the TMEM120 family.
CC {ECO:0000256|ARBA:ARBA00009700}.
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DR RefSeq; XP_014052556.1; XM_014197081.1.
DR RefSeq; XP_014052557.1; XM_014197082.1.
DR GeneID; 100196226; -.
DR CTD; 100005623; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR012926; TACAN/TMEM120B.
DR PANTHER; PTHR21433:SF1; ION CHANNEL TACAN; 1.
DR PANTHER; PTHR21433; TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA; 1.
DR Pfam; PF07851; TMPIT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 135..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 50..77
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 342 AA; 40671 MW; C6C517D78993ECB8 CRC64;
MLFNQTSLAD CLQEWECLEK DFQRVQETHR LYKQKLEEVS KLQDSCSNAI ARQRKKLKEL
TVSLEECKET LSTEEMNAID GIQESIKDRP NVFFEMESFL PKKNGLYLSL VLGNVNVTLL
NKHSKFAYKD EYEKFKLVLT VLLLVFSFTC RFIFSYRALD ALFNFLLVWY YCTLTIRESI
LISNGSRIKG WWVFHHYVFC FLSGVMLTWP EGILYQMFRN QFLTYCLYQS FVQFLQYYYQ
SGCLYRLRAL GESHNMDLTV EGFQSWMWRG LTFLLPFLFF GHFWQLYNGL TLFRMAQLPE
CKEWQVSMCG CSYLVLFMGN FSTTLGVVYH KYIHNQDKSK SL
//
