ID A0A1S3RM42_SALSA Unreviewed; 1054 AA.
AC A0A1S3RM42;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Disks large homolog 2 isoform X8 {ECO:0000313|RefSeq:XP_014053401.1};
GN Name=LOC106603804 {ECO:0000313|RefSeq:XP_014053401.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014053401.1};
RN [1] {ECO:0000313|RefSeq:XP_014053401.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014053401.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR RefSeq; XP_014053401.1; XM_014197926.1.
DR AlphaFoldDB; A0A1S3RM42; -.
DR OrthoDB; 2879721at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12032; SH3_DLG2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR035759; DLG2_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR015143; L27_1.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF09058; L27_1; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 4..64
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 287..374
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 382..469
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 614..695
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 729..799
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 855..1039
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 136..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1054 AA; 117488 MW; 354689371321EFA5 CRC64;
MPVRKKDTAR ALELLEDYCA KLTKPEEQQL KTAIQRVMGV FKSSLFQALL DIQEFYEVTL
LNTQKSCKQK LEEVNHMADK WEQTGTGSLT AVLQHACPTE MRERSSSEHG GKDQTPISVK
VSEEYSLPGC VTSVCREGPR RSNRPAAVQG SPHTGPPPAC MNPALMSTPW QYRYQDEDSP
PEHGFPRLTN EVRAPELVHV SEKNLSEIEN VHGYVSHSHI SPLKHRVRVR PILVILQPAL
VTRFDLTYPG VTAANYLASP APIIVNTDTL ESVPYVNGTE IEYEFEEITL ERGNSGLGFS
IAGGTDNPHI GDDPGIFITK IIPGGAAAED GRLRVNDCIL RVNDADVSEV SHSKAVEALK
VAGSIVRLYV RRRRPMLETV IEIKLIKGPK GLGFSIAGGV GNQHIPGDNS IFVTKIIDGG
AAQKDQRLQV GDRLLMVNNY TLEEVSHEEA VAILKNTSDV VYLKVGKPTS VYLSDPYGPP
DITHSFSPAM ENHISSVGNN GTLEYKCTLP PMPISPGRYS PLPKHLLGEE DINRLDGFSF
LRNASIDDGE AHRFESQHFQ LRPPEPVYST VNKAPSPHHY SPVECDKSLL HSIPFPHYHL
GLLPDFEITR DPRRMVLHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDQI
LSVNGIDLRG ATHEQAAAAL KGAGQTVTII AQYRPEEYGR FEAKIHDLRE QMMNHSMSSG
SGSLRTNQKR SLYVRALFDY EKAKDSGLPS QGLSFRYGDI LHVINASDDE WWQARRVTPD
GDSEEMGVIP SKRRVERKER ARLKTVKFNA KPGTIDSKGD IPGIGDDGYG TKTLRSQEDM
ILSYEPVIRQ EINYARPVII LGPMKDRIND DLISEFPDKF GSCVPPANCS GQPDTTRSRR
DYEVDGRDYH FVMSREQMEQ DIQEHKFIEA GQYNDNLYGT SVQSVKYVAE RQGKHCILDV
SGNAIKRLQV AQLYPIAIFI KPRSIDSLME MNKRLTEEQA RKTFDRAMKL EQEFGEFFTA
LVQGDTLEDI YNHCKMVIEE HSGPYIWIPS KEEL
//
