ID A0A1S3RM69_SALSA Unreviewed; 1004 AA.
AC A0A1S3RM69;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Disks large homolog 2 isoform X17 {ECO:0000313|RefSeq:XP_014053410.1};
GN Name=LOC106603804 {ECO:0000313|RefSeq:XP_014053410.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014053410.1};
RN [1] {ECO:0000313|RefSeq:XP_014053410.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014053410.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR RefSeq; XP_014053410.1; XM_014197935.1.
DR AlphaFoldDB; A0A1S3RM69; -.
DR OrthoDB; 2879721at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12032; SH3_DLG2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR035759; DLG2_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR015143; L27_1.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF09058; L27_1; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 4..64
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 287..374
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 382..469
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 546..627
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 661..731
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 805..989
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 136..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1004 AA; 112168 MW; 71B25510690B4EDD CRC64;
MPVRKKDTAR ALELLEDYCA KLTKPEEQQL KTAIQRVMGV FKSSLFQALL DIQEFYEVTL
LNTQKSCKQK LEEVNHMADK WEQTGTGSLT AVLQHACPTE MRERSSSEHG GKDQTPISVK
VSEEYSLPGC VTSVCREGPR RSNRPAAVQG SPHTGPPPAC MNPALMSTPW QYRYQDEDSP
PEHGFPRLTN EVRAPELVHV SEKNLSEIEN VHGYVSHSHI SPLKHRVRVR PILVILQPAL
VTRFDLTYPG VTAANYLASP APIIVNTDTL ESVPYVNGTE IEYEFEEITL ERGNSGLGFS
IAGGTDNPHI GDDPGIFITK IIPGGAAAED GRLRVNDCIL RVNDADVSEV SHSKAVEALK
VAGSIVRLYV RRRRPMLETV IEIKLIKGPK GLGFSIAGGV GNQHIPGDNS IFVTKIIDGG
AAQKDQRLQV GDRLLMVNNY TLEEVSHEEA VAILKNTSDV VYLKVGKPTS VYLSDPYGPP
DITHSFSPAM ENHISSVGNN GTLEYKCTLP PMPISPGRYS PLPKHLLGEE DINRLDGFSF
LRDPRRMVLH KGSTGLGFNI VGGEDGEGIF VSFILAGGPA DLSGELRRGD QILSVNGIDL
RGATHEQAAA ALKGAGQTVT IIAQYRPEEY GRFEAKIHDL REQMMNHSMS SGSGSLRTNQ
KRSLYVRALF DYEKAKDSGL PSQGLSFRYG DILHVINASD DEWWQARRVT PDGDSEEMGV
IPSKRRVERK ERARLKTVKF NAKPGTIDSK GSFNDKRKNN FIFTRKFPFY KNKELGEQDG
SDSERSQEDM ILSYEPVIRQ EINYARPVII LGPMKDRIND DLISEFPDKF GSCVPPANCS
GQPDTTRSRR DYEVDGRDYH FVMSREQMEQ DIQEHKFIEA GQYNDNLYGT SVQSVKYVAE
RQGKHCILDV SGNAIKRLQV AQLYPIAIFI KPRSIDSLME MNKRLTEEQA RKTFDRAMKL
EQEFGEFFTA LVQGDTLEDI YNHCKMVIEE HSGPYIWIPS KEEL
//
