ID A0A1S3RPI9_SALSA Unreviewed; 264 AA.
AC A0A1S3RPI9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Deoxycytidine kinase-like {ECO:0000313|RefSeq:XP_014053624.1};
GN Name=LOC106603918 {ECO:0000313|RefSeq:XP_014053624.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014053624.1};
RN [1] {ECO:0000313|RefSeq:XP_014053624.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014053624.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DCK/DGK family.
CC {ECO:0000256|ARBA:ARBA00007420}.
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DR RefSeq; XP_014053624.1; XM_014198149.1.
DR AlphaFoldDB; A0A1S3RPI9; -.
DR STRING; 8030.ENSSSAP00000002341; -.
DR PaxDb; 8030-ENSSSAP00000002341; -.
DR GeneID; 106603918; -.
DR KEGG; sasa:106603918; -.
DR OMA; QLHYKHE; -.
DR OrthoDB; 315858at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR Bgee; ENSSSAG00000001218; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01673; dNK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002624; DCK/DGK.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513:SF51; DEOXYCYTIDINE KINASE 2; 1.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000705; DNK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Kinase {ECO:0000313|RefSeq:XP_014053624.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transferase {ECO:0000313|RefSeq:XP_014053624.1}.
FT DOMAIN 25..261
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
FT ACT_SITE 128
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT BINDING 29..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT BINDING 54
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 87
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 98
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 129
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 134
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 189..193
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT BINDING 198
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 241..243
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ SEQUENCE 264 AA; 31012 MW; 4549CD454B2EFB77 CRC64;
MATPPKRICS SPGFDNSFEK RTKKISIEGN IAAGKSTLVH ILEKSSEEWE VIPEPIGKWC
NVQNTDNEYK ELSTSQKSGG NLLQMLYDKP SRWSYTFQSY ACLSRVRAQL QPPSAKLQQA
EKPVQFFERS VYSDRYVFAS NLFESGDMNE TEWDIYQDWH SWLLSQFESQ IELDAMIYLR
ADPQRCMQRL HCRGREEEQG IPIDYLEQLH YKHECWLYHR STQLAFEYLK DVPILVLDVN
DDFKNDQIKQ EAVLDKVREF LSTL
//
