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Database: UniProt
Entry: A0A1S3RSK4_SALSA
LinkDB: A0A1S3RSK4_SALSA
Original site: A0A1S3RSK4_SALSA 
ID   A0A1S3RSK4_SALSA        Unreviewed;      1674 AA.
AC   A0A1S3RSK4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   05-JUN-2019, entry version 19.
DE   SubName: Full=rap guanine nucleotide exchange factor 2 isoform X7 {ECO:0000313|RefSeq:XP_014054709.1};
GN   Name=rapgef2 {ECO:0000313|RefSeq:XP_014054709.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014054709.1};
RN   [1] {ECO:0000313|RefSeq:XP_014054709.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014054709.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
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DR   RefSeq; XP_014054709.1; XM_014199234.1.
DR   GeneID; 106604533; -.
DR   CTD; 9693; -.
DR   OrthoDB; 31139at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 2.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 2.60.120.10; -; 2.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR030739; RapGEF2.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF217; PTHR23113:SF217; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00100; cNMP; 2.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF51206; SSF51206; 2.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN       37     84       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   DOMAIN      296    361       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   DOMAIN      428    541       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      546    616       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      780    866       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN      891   1118       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   REGION      201    261       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   REGION      639    666       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   REGION     1178   1215       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   REGION     1252   1335       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   REGION     1412   1434       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   REGION     1486   1674       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   COMPBIAS    201    226       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   COMPBIAS    242    257       Acidic. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   COMPBIAS    639    660       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   COMPBIAS   1195   1213       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   COMPBIAS   1266   1335       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   COMPBIAS   1418   1434       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   COMPBIAS   1502   1516       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   COMPBIAS   1518   1532       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
FT   COMPBIAS   1596   1628       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3RSK4}.
SQ   SEQUENCE   1674 AA;  186417 MW;  74906F5224B56919 CRC64;
     MASYVDNSFR QAVMMNPAER TQQDLEIVYS YLHGMEALSN LREHQLRIMC ETVRYERHEA
     NEVLYYPDDV GSCWYILLSG SVFIKESMFL PRSSFGKRSA GSLRRGCECI VLEPSEMIVV
     DYMEENEEYF QRQASHRQSR RRFRKINQKG ERQTIIDTVD PYPTGKPPIV RGYHTECIKA
     QLPADFSRLH LADGLHPQVT HVSSSHSGCS ITSDSGSSSL SDIYQATENE PGDMDLSGLP
     ETAVDSEEDD DEEDIERSSD PLMSRDIVRD CLEKDPMDRT DDDIEQLLEF MHQLPAFANM
     TMSVRRELCA VMVFAVVERA GTIVLNDGEE LDSWSVILNG SVEVTYPEGR PEILCMGNSF
     GVSPTIEKEY MKGVMKTKVD DCQFVCIAQQ DYCCILNQVE KNMQKVEEEG EIVMVKEHRE
     LDRTGTRKGH IVIKGTKERL TMHLVEEHSV VDPTYIEDFL LTYRTFLSSP MVVGNKLLEW
     FHDPSLRDKV TRVVLLWVNN HFNDFEGDPA MTNFLEEFEN NLEREKMYGH LRLLNIACAA
     KAKLRLVTLT KPSREAPLAF TLLGGSEKGF RIFIDSVEPG SKAAEAGLKR GDQILEVNGQ
     NFENVQLTKA NEILRNNTHL SISVKTNLLV FKELLARPEH DHEAEGEETP EVDRKNGAPA
     HLPKIGDIKK GSRYSIPDLA VDVEQVMGLE KASKKAKANT VGGRNKLKKI FDKTLTSILP
     PKPYNDVGVG QSQDDSIVGL KQSKQIPAAL PVSGSLSSSN PDLLQSHHRI LDFNNPPDMS
     DQVLRVFKAD QQSRYIMIGK DTTAKEVVAQ AIREFALTAA PEAYSLCEVS ITPEGVIKQR
     RLPEQLSKLA DRIQLSGRYY LKSNMETETL CSDEDAQDLL REGQISLLQL STMEVATQLS
     MRAFELFCAI EPTEYIDDLF KLKSKTGSFC LKRFEEIINQ ETFWVASEVT REPNQLKRMK
     TVKHFIKIAL HCRECKNFNS MFSIISGLNL APVSRLRGTW EKLPSKYEKL FGDLQDLFDP
     SRNMAKYRNV LNNQNLQPPI IPLFPVIKKD LTFLHEGNDS KVDGLVNFEK LRMIAKEIRH
     VGRMASVNMD PALMFRTRKK KWRSLGSLSQ GSANAAVLDV TQTGGHKKRV RRSSFLNAKK
     LYEDAQMARR VKQFLSNLSL ETNEEALQTL SLQCEPSINT LPKNAGGSKR PDTSPVVSRA
     ASQQRSHLQK GNQALQVPAV ALYPSRKKVP VKDLPPFGTS SPQSLKKILS LSEEASERHK
     RQTEDTVSNT TSQLSSPPTS PQSSPKKGLG TLKGQSVRKV TFTSKQTATG YPRTGDAYSD
     SGHSEISSRS SLVSNSSFDM AQEERRGLRH SGGVGDPHAG GVRLERRATT DPDQYSLGSY
     SSMQDCRGLY TCATVLSPSS EELTQDQGDR VSLDAADSGR GSWTSCSSGS HDNIQTMQQG
     RSWETLAFGP GGVVSMGVHP PGGPEAFIGV PSGLWASQAR GSWASASSSS SSAAYWGEDS
     EGDTGTIKRR GGKDVNADPE TSSITSMGSD EAKQHGRPSP ITAGNKGLIT RKESRYREPP
     PTPPGYTALT ISDFSEGQTQ SPPPPTAPSH SGRRPPDYST ALQRSRMVTQ SPDSQHHHQS
     QQHPGSGTTK RHGLHRTRSP DEDEEPEEEE GESLSPKLVA LRKTVAHTPE TTRP
//
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