ID A0A1S3RUN1_SALSA Unreviewed; 1532 AA.
AC A0A1S3RUN1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Slit homolog 3 protein-like isoform X1 {ECO:0000313|RefSeq:XP_014055552.1};
GN Name=LOC106604933 {ECO:0000313|RefSeq:XP_014055552.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014055552.1};
RN [1] {ECO:0000313|RefSeq:XP_014055552.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014055552.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_014055552.1; XM_014200077.1.
DR STRING; 8030.ENSSSAP00000045214; -.
DR PaxDb; 8030-ENSSSAP00000045214; -.
DR Ensembl; ENSSSAT00000072027; ENSSSAP00000045214; ENSSSAG00000044758.
DR GeneID; 106604933; -.
DR KEGG; sasa:106604933; -.
DR OMA; PACNANS; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000087266; Chromosome ssa05.
DR Bgee; ENSSSAG00000044758; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 6.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR PANTHER; PTHR45836:SF9; SLIT HOMOLOG 3 PROTEIN; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01463; LRRCT; 4.
DR Pfam; PF01462; LRRNT; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00274; FOLN; 3.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM00369; LRR_TYP; 18.
DR SMART; SM00082; LRRCT; 4.
DR SMART; SM00013; LRRNT; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1532
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010331900"
FT DOMAIN 917..952
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 954..993
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 995..1031
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1041..1079
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1081..1117
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1126..1162
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1165..1339
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1376..1411
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1415..1451
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1456..1531
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 942..951
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 983..992
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1069..1078
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1107..1116
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1152..1161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1312..1339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 1380..1390
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1401..1410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1419..1429
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1441..1450
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1532 AA; 168423 MW; 5D11687C346BA54A CRC64;
MLPTVQEKWT AYHWGIWVLM CGLLCSAAVN GCPHKCSCSG SHVDCQGQGF RTVPKGIPRN
AERLDLDRNN ITRITKVDFS GIKNLRVLHL EDNQITVIER GAFQDLKQLE RLRLNRNKLQ
VLPELLFQST PKLGRLDLSE NQIQAVPRKA FRGITTVKNL QLDSNHISCI EDGAFRALRD
LEILTLNNNN ITLIPLSSFN HMPKLRTLRL HSNNLHCDCH LSWLSDWLRQ RHGLAPFTQC
MAPASMRGLN IPDVQKKDFT CTGPAQAEPR TCVPQASVCP ISCTCNNNIV DCRHKGLTEI
PANLPEGIVE IRLEQNLIKN IPAGAFSPYK KLKRIDLSKN QISDIAADAF TGLRSLTSLV
LYGNKIAEIP KGLFDGLVSL QLLLLNANKI NCLRVNTFQD LQSLNLLSLY DNKLQTISKG
LFAPLRSIKT LHLAQNPFMC DCHLKWLADY LFDNPIETSG ARCSHPRRLA NKRISQVKGK
KFRCTGTEDY RSRLSGECFQ DLVCPEKCRC EGTVVDCSNL KLTKLPPHLP EHTTDLRLND
NEISVLEAVG TFKKLPNLKK INLSNNKLRD IREGAFDGAA GVLEVLLTGN KLQALQGRMF
RGLTGLKTLM LRSNQIGCVD NTTFTGLSSV RLLSLYDNRI STIAPGAFTT LHSLSTINLL
SNPYVCDCHL AWLGLWLKKT RVVSGNPRCQ KPAFLKEIPI QDVANPDFTC DGTEENVCFP
VSRCPESCTC SDTVVRCSNR GLRTLPKGIP KDTTELYMEG NLLISIPKEL STLKQLSLVD
LSNNSISTVA SMTFSNMTQL ATLILSYNQI RCIQVHAFDG LKSLRLLTLH GNDLSTIPEG
AFNHLTSLSH LALGANPLYC NCDLRWLSQW VKAGFKEPGI ARCTGPPDMA DRLLLTTPLN
RFQCKGPVDL NLMAKCAPCL AGPCLNNGTC ASDVSGSYHC TCPIGYKGQN CEIAINACIS
LPCANGGTCH LMPGQVEQFS CACPPGYEGL QCEVNPDDCE DNDCENNSTC VDGINNYTCV
CPPNYTADRY DMGKGDLCEE VVDPCMQGFD PCQHDSKCIP LTKGFRCECL PGYVGQHCEQ
DYNDCLENKC QHGAECVDAV NGYTCVCKEG FSGLFCENPP PMILLQTSPC DQSECQNGAQ
CLVVEGEPVC RCLPGFTGNK CHKIVTVHLL GKETYLELPS IKIRNSVHIS LQVATDKDNG
ILLYKEDHDP LALELYQGHI RIIYDIANYP PTTVYSVESV SDGLFHTVEL LIQNHSLSLV
VDKGSPKSLG KLPRQPSVDH NTQLYIGGVP SAVMASRLRS GPDRSPQAFN GCIHNVRING
ELQDLGAALR GLEGILPGCH SCSVCAQGAC RQRGETGVSC ECPPSRSGPL CDQKIAPSPC
QSSRCVHGLC VPKASSYSCH CADGYTGQYC DRREEPQACK GHQCGHGECR VTESGEPSCH
CQPGYTGPTC DAEPACQGEV VRELLKRHQP MKTCTSTSKI PRVECPRACD GGFCCAPSKS
RRRKVVFKCT DGSSYSEEME TTLECGCAKC PL
//
