ID   A0A1S3RVA5_SALSA        Unreviewed;      1345 AA.
AC   A0A1S3RVA5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Ras/Rap GTPase-activating protein SynGAP-like isoform X10 {ECO:0000313|RefSeq:XP_014056230.1};
GN   Name=LOC106605281 {ECO:0000313|RefSeq:XP_014056230.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014056230.1};
RN   [1] {ECO:0000313|RefSeq:XP_014056230.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014056230.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_014056230.1; XM_014200755.1.
DR   STRING; 8030.ENSSSAP00000013375; -.
DR   PaxDb; 8030-ENSSSAP00000013375; -.
DR   Proteomes; UP000087266; Chromosome ssa05.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd04013; C2_SynGAP_like; 1.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   CDD; cd22265; UDM1_RNF168; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR021887; DAB2P_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF25; RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF12004; DAB2P_C; 2.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          208..242
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          233..351
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          416..608
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          810..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          861..894
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1029..1190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1236..1295
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1345 AA;  150868 MW;  E3C6A5DA9ECB1328 CRC64;
     MSYVPFQDAR CAVPPSYRPH APSFAAPSYD RPDWNPRLCV ISGNQLYMLD QEEVHPLLMR
     ERRSELHRNK LLRRTVSVPV EGRHHPEMEN ARARRKSIAN VKQPSMEIPP TAPPQSFRQS
     SFLSRRLKGS IKRAKSQPKL DRTSSFRHMI LPRFRSADQD RTRLMQSFKE SHSHESLLSP
     SSAAEALDLT LDEDAIIKPV HSSILGQEYC FEVTTASGTK CFACRSGAER DKWIENLQRA
     VKPNKDNSRR VDNVLKLWII EARELPAKKR YYCELCLDDM LYARTTSKPR TDTVFWGEHF
     EFNNLPAVRN LRLHLYKETD KKRRKEKSTY LGLVSIPISS ITGRQFVEQW YPVIQPSVLA
     KGQAGGKIIN ASLRLKSRYQ TMSILPMELY KEFAEYVTNN YRTLCAVLEP LLSVKSKEEV
     ACALVHILQS TGKAKDFLSD MAMCEVDRFI DREHLIFREN TLATKAIEEY LKLIGHKYLK
     DAIGEFIRAL YESEENCEVD PMRTPPSVLP DHQANLRMCC ELALCKIVNS HCVFPRELKE
     VFASWRVRCA ERGREDIADR LISGSLFLRF LCPAVMSPSL FNLTQEYPDE QTSRTLTLIS
     KVVQNLANFS KFGMKEEYMC FMNEFLEMEW GSMQQFLYEI SNLDSVSNAG GFEGYIDLGR
     ELSILHSLLW EVMAQLSKSS NPNPQDAIIK LGPLPRLLND ISMALRNPHL QRQPSHQNQT
     DRVHERQTER LLSRPSFHRG VSSEFQNLMM KDLNSSIDIT RLPSPTSGVS SGGVMPSRAH
     AQLSFQERDH PHRASKDVFY VTRPPLARSS PAYCTSSSDI TEPDHKDSTM NSVSNLQSVA
     MLNSSQASIT GMGSFGGLSS QGGGGLGSGL SGQLRAGGRH SAGSGGSSMS GGLRLSQLSQ
     MGTTTDSLSQ QQQQQAAALR YPLSFQNPLF HLATGTADGP HLHHQHSRAH LPPPLLLAPE
     PDHGGSHQAY IPQFAHGGFS RSEDLSTLRT GAGHLGQPAI IHSHSYSDDY SRADYARRQL
     SMHGQDNLQQ QMGMASQTGT SHSSLATPPS TVQPVRQSSI APPSAQRVKS QTSHQLSVSA
     AAAPTPSAKT RPPSANLSPE SGYGGRQQAP RQQLSVKDNT APGLPHQQSS VRESQGPQGP
     QGGTTTTIQQ SQQQQQQQQQ PQQQHLLKPS ISKQGSGQSP STLNPPTPAN ERTVAWVSNM
     PHLSADITLE ANRIDREEFK LKEYSKSMDE SRLDRVKEYE EEIHSLKERL IMSHRKLEEY
     EKRLLSQEQQ TNKILSQYQS RLEDSERRLR QQQVEKDSQI KGIINRLMAV EDEIRGGAVV
     EPPKANVRVF ADQPITQLRG GQSGT
//