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Database: UniProt
Entry: A0A1S3RYP6_SALSA
LinkDB: A0A1S3RYP6_SALSA
Original site: A0A1S3RYP6_SALSA 
ID   A0A1S3RYP6_SALSA        Unreviewed;       585 AA.
AC   A0A1S3RYP6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   31-JUL-2019, entry version 12.
DE   SubName: Full=neuronal acetylcholine receptor subunit alpha-7-like {ECO:0000313|RefSeq:XP_014057353.1};
GN   Name=LOC106605885 {ECO:0000313|RefSeq:XP_014057353.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014057353.1};
RN   [1] {ECO:0000313|RefSeq:XP_014057353.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane
CC       protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane
CC       {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00569391}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   RefSeq; XP_014057353.1; XM_014201878.1.
DR   GeneID; 106605885; -.
DR   KEGG; sasa:106605885; -.
DR   OrthoDB; 845098at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|SAAS:SAAS00458005};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00458000};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00081591};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00458066};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457919};
KW   Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00172123};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00081626};
KW   Receptor {ECO:0000256|SAAS:SAAS00172128,
KW   ECO:0000313|RefSeq:XP_014057353.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Synapse {ECO:0000256|SAAS:SAAS00103537};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081549}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    585       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010280979.
FT   TRANSMEM    265    289       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    296    318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    330    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       61    264       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      271    407       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      388    416       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      428    555       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    391    416       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    445    463       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    526    542       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   585 AA;  65169 MW;  470A8A93E6C07E22 CRC64;
     MASMLIHFSL LCSTVFQPPH CPLSPALLLH PHPFPSFLLL IPLPLSLPPP LSVSEQGPHQ
     RNLLRDLLRD YNRMERPVAN DSLPLTVRFS YTLLQVMNVD EKNQILTTNA WLQMQWFDHY
     LQWNQSEYPG VKTLRFTTDQ VWIPDILLYN SAHDKFDATF KSYVLVNSSG FCEYLPPGIF
     SSACEVDVRW FPFDVQHCEL KFGSWTFDGW LLDLQMQEAD LSGYMSNGEW ELLGVPGDRH
     EIFYECCTEP YSDVTFVVTL RRRTLFYALN LLVPCVLISS LTLLVFLLPA QSGEKIGLGI
     TILLSQTFFM LLVAEIMPAT SDCIPLIGQY FVSTMVTVGM SVVATVVVLQ YHHHDPNSGD
     MPQWVELVLL QWVPWFLRMK CPEEWGELTP HHSPSNPQTK TCSSPHPTTT PAPLTYPQSL
     TSLQASLSQL SQPLPHPPSN PTLQSYPNYN PNHQPNIHLN PNRYPQPLLN LHPNLHPNLP
     SIPHAQPNGH LPYMGFQSPP EPDPAVTWRG GGEERRGSDT HPPSSTTLGS PPPQPPTSPD
     PDPSSSGSSC VEDGAGASVV GTCHAQAGVL QAGEAEAMAE GRGTQ
//
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