ID A0A1S3RZF6_SALSA Unreviewed; 508 AA.
AC A0A1S3RZF6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Rap guanine nucleotide exchange factor 5-like {ECO:0000313|RefSeq:XP_014057347.1};
GN Name=LOC106605879 {ECO:0000313|RefSeq:XP_014057347.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014057347.1};
RN [1] {ECO:0000313|RefSeq:XP_014057347.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014057347.1; XM_014201872.1.
DR AlphaFoldDB; A0A1S3RZF6; -.
DR KEGG; sasa:106605879; -.
DR OrthoDB; 5473909at2759; -.
DR Proteomes; UP000087266; Chromosome ssa05.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF26; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 111..256
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 397..508
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 508
FT /evidence="ECO:0000313|RefSeq:XP_014057347.1"
SQ SEQUENCE 508 AA; 58398 MW; 352467325D794EFE CRC64;
MLRMGTRPRP PPDLRQREEG RLLAAVALVE QEEDEEEDSE EGSSGSGGSD SASWAEEGAK
ATKVPTFDVP YFRYIDEEES EGEGDGQEVW SSSRSLSSIE DDSSSDSVVS DRYVVVSGTP
EKILEHLLSV LRLDNHRDDQ ENTQQTKESE PLLDDFLLTY LVFMSTSDLC QALLVHYCSR
RHHQGKDKGK EVLDRKRQVL HLVTQWTTLY RDFLREDEHV KLFMKTLYRF LLDDLYEYPT
LEKEQKDLQK LLRLHRRHTA EEYSPHRKSK ALSHQLSLKE NGLPTRRTQR ETREVLCHVY
VSMDSYLSVR SLASVVAQGL LQEVAERLDV PLEELVLLAV TYPGEKLLLK PQDRLYSDSL
TAVGRLHVCR KDLSEVMNPF TDNAELQQRS ARMLSMNTWD VAVTLTNFDW SVFNSIHEQE
LVYFTFSRHA SGGHTVALEL LLQRCNEVQL WVMTEVLMCP TLCNRVQLIK KFIKIAAHCK
AQRNLNSFFA IVMGLNTAAV SRLSQTWE
//
