ID   A0A1S3RZK7_SALSA        Unreviewed;       434 AA.
AC   A0A1S3RZK7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Protein prune homolog isoform X2 {ECO:0000313|RefSeq:XP_014057635.1};
GN   Name=prune {ECO:0000313|RefSeq:XP_014057635.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014057635.1};
RN   [1] {ECO:0000313|RefSeq:XP_014057635.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the PPase class C family. Prune subfamily.
CC       {ECO:0000256|ARBA:ARBA00010331}.
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DR   RefSeq; XP_014057635.1; XM_014202160.1.
DR   AlphaFoldDB; A0A1S3RZK7; -.
DR   OrthoDB; 51958at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa05.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR   Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR   Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR   InterPro; IPR001667; DDH_dom.
DR   InterPro; IPR038763; DHH_sf.
DR   InterPro; IPR004097; DHHA2.
DR   InterPro; IPR038222; DHHA2_dom_sf.
DR   PANTHER; PTHR12112; BNIP - RELATED; 1.
DR   PANTHER; PTHR12112:SF47; EXOPOLYPHOSPHATASE PRUNE1; 1.
DR   Pfam; PF01368; DHH; 1.
DR   Pfam; PF02833; DHHA2; 1.
DR   SMART; SM01131; DHHA2; 1.
DR   SUPFAM; SSF64182; DHH phosphoesterases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          219..354
FT                   /note="DHHA2"
FT                   /evidence="ECO:0000259|SMART:SM01131"
SQ   SEQUENCE   434 AA;  48100 MW;  63FBF59DAA0D5887 CRC64;
     MDIFLKSCRN VLKGNADGSP GFHVVLGNEA CDLDSMVSAL AYAYFLSKTL DSGKIPLPVL
     NIPRQEFPLR TDNTFLLRES GLSQDDLVFR DEVDLGSLHR AGRLDLTLVD HNVLPSSDRD
     LEEAVLEVID HHLLERKPSP SCPVTVETVG SCTTLVTERI IQKAPEVLDQ QVAQLLYGTI
     VLDCVNMAPE AGKVTPKDSQ YAVLLETHFP NLPPRGVLFQ SLQNAKFDVS GLTTEQMLLK
     DMKVASEGDL KLAAFLQRQS LQQELCEFCH KHSYNLVVAM TISFNNNKEP FRQLAVYSSS
     TLYRGEMSQA LEKARSPSLS LSPMSSPYSD IRAYLQGNTL ASRKKVLPII KDFLRDRERR
     EVQGGNLEES YEAPRQRACT EDAGIEEDSY FPPTPMNSLV EGCPLDNGLP KISAEALTEK
     FSKMASEEEN AGGL
//