ID A0A1S3S5G2_SALSA Unreviewed; 784 AA.
AC A0A1S3S5G2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=LOC106607295 {ECO:0000313|RefSeq:XP_014059588.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014059588.1};
RN [1] {ECO:0000313|RefSeq:XP_014059588.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014059588.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR RefSeq; XP_014059588.1; XM_014204113.1.
DR AlphaFoldDB; A0A1S3S5G2; -.
DR STRING; 8030.ENSSSAP00000021685; -.
DR PaxDb; 8030-ENSSSAP00000021685; -.
DR Ensembl; ENSSSAT00000208369; ENSSSAP00000155499; ENSSSAG00000010616.
DR KEGG; sasa:106607295; -.
DR OMA; IWLNRQQ; -.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000087266; Chromosome ssa06.
DR Bgee; ENSSSAG00000010616; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16855; STAT5_CCD; 1.
DR CDD; cd16849; STAT5_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR046994; STAT5_CCD.
DR InterPro; IPR035858; STAT5a/5b_DBD.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF39; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 589..690
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 134..168
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 784 AA; 89837 MW; 8DCC772B6E659A19 CRC64;
MAVWIQAQQL QGDALHQMQS LYGQHFPIEV RHYLSQWLEG QLWDVIDLEN PQEEFKAKRL
LDSLIQELQN KAEHQVGEDG FLLKIKLGHY ASQLKSTYDR CPLELVRCIK HILYTEQRLV
REASNSSSPV GGMMDSMSQK YQQINQAFEE LRLLTQDTEN DLRKLQHNQE YFIIQYQESL
RIQAQLTSLA TLPPADRQLR EPTLLSKRAT VEAWLTREAN TLQKYRLDLA EKHQKSLQLL
RKQQTIILDD ELIHWKRRQQ LAGNGGPPEG GLDILQSWCE KLAETIWQNR QQIRRAEHLR
QQLPIPGPIE ELLNDLNSTI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
NVHMNPPQVK ATIISEQQAK ALLKNENTRN DSSGEILNNN CVMEYHQATG TLSANFRNMS
LKRIKRSDRR GAESVTEEKF TILFESQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA
TVLWDNAFAE PGRVPFIVPD KVLWPQLCEA LNMKYKAEVQ SNRGLSEENL VFLAQKAFSS
SSINPDDYRG MTMTWSQFNR ESLPGRNFTF WQWFDGVMEL TKKHLKPHWN DGAILGFVNK
QQAQDMLMSK PNGTFLLRFS DSEIGGITIA WVAENPNKPG ERMVWNLMPY TTKDFSIRSL
ADRISDLNHL LFLYPDRPKD EVFSKYYTPP LSKAVDGYVK PQIKQVVPEF TTTNPDPAAN
PTYMDHGASP VVSHPPNYGI YQPMSDSMLD ADGDFDLDDT MDVARHVEEL LRRPMENQWR
GQQS
//