ID A0A1S3S5Q6_SALSA Unreviewed; 518 AA.
AC A0A1S3S5Q6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Sorting nexin-8-like isoform X2 {ECO:0000313|RefSeq:XP_014059670.1};
GN Name=LOC106607331 {ECO:0000313|RefSeq:XP_014059670.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014059670.1};
RN [1] {ECO:0000313|RefSeq:XP_014059670.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014059670.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR RefSeq; XP_014059670.1; XM_014204195.1.
DR AlphaFoldDB; A0A1S3S5Q6; -.
DR OrthoDB; 5475877at2759; -.
DR Proteomes; UP000087266; Chromosome ssa06.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR46571; SORTING NEXIN-8; 1.
DR PANTHER; PTHR46571:SF1; SORTING NEXIN-8; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 130..245
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 518 AA; 59400 MW; 2781AEF1EC936290 CRC64;
MAGELNEGSV PPYYREVYEA IRSKIDERVQ VEVFQRLLSR TDLPSAVQGQ IAEHVDYTDG
FLSKLSLYKA LALIALAQQG KQPSPKLLEN CIQEFPKPQL GEFKDLQTLR MQPTQESPLK
VSQTLGKLLA RDTVQVELIP EKKGLFLKHV EYQITSQHFK ISVYRRYSDF DVFHELLLQR
FAYRMVPALP PKRMLKGVLT SMSERDFIEG RRRALGRFIN LVARHPFFSE DELVKTFLTF
NGSDVQVKMR DACKKMGDEF MTNTMATLAK EYLPADIQAQ FSSSRELIRN IHNSFHKLRD
RAEKMAERSK ENATDLLMFG RELSTLGSDG SPIPSLASSQ STWGILRQSL KGLSVEFALL
ADKGAQQGRR EEDDVVEKLN LFLDLLQSYR DLCERHEKGV LHEHQRALQK YGMMKRQMMS
ATVQPKEQVS VEQLESRIVQ ENAIQTMELR NYFSLFCLHQ ETQLIFTYLP ITSHILGAFV
NSQVQGHQEM GAVWNDLQQK LGCLFGVDEM QSPPLTPK
//
