ID A0A1S3S6A5_SALSA Unreviewed; 543 AA.
AC A0A1S3S6A5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Platelet-derived growth factor subunit B {ECO:0000256|ARBA:ARBA00018117};
DE AltName: Full=PDGF-2 {ECO:0000256|ARBA:ARBA00031888};
DE AltName: Full=Platelet-derived growth factor B chain {ECO:0000256|ARBA:ARBA00032481};
DE AltName: Full=Platelet-derived growth factor beta polypeptide {ECO:0000256|ARBA:ARBA00032702};
GN Name=LOC106607441 {ECO:0000313|RefSeq:XP_014059866.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014059866.1};
RN [1] {ECO:0000313|RefSeq:XP_014059866.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014059866.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|RuleBase:RU003818}.
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DR RefSeq; XP_014059866.1; XM_014204391.1.
DR AlphaFoldDB; A0A1S3S6A5; -.
DR STRING; 8030.ENSSSAP00000006411; -.
DR PaxDb; 8030-ENSSSAP00000006411; -.
DR Ensembl; ENSSSAT00000006854; ENSSSAP00000006411; ENSSSAG00000003188.
DR GeneID; 106607441; -.
DR KEGG; sasa:106607441; -.
DR OMA; HWAHNSS; -.
DR OrthoDB; 4257902at2759; -.
DR Proteomes; UP000087266; Chromosome ssa06.
DR Bgee; ENSSSAG00000003188; Expressed in muscle tissue and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF2; PLATELET-DERIVED GROWTH FACTOR SUBUNIT B; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU003818};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..543
FT /note="Platelet-derived growth factor subunit B"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010182767"
FT DOMAIN 76..179
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT REGION 61..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..534
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 62098 MW; 6D8E7350EC507593 CRC64;
MSSWVWVQLL ALFATCLRSG SAEGDPLPPG LVELVRSNPI SSIEDLQLLL LSDSVDEDVS
EDFVPSGQHS NNASNRLPRS LDAQPAQQAL CKVRTEVMEV TRAMLDRSNA NFMLWPPCVE
VQRCSGCCNT KTLQCVPVLM HTRHLQVMKI QYVEKRPNYS KAVVSVHDHV ECRCQPAPRP
PAVPKKKSTP RRQQKDNKGE GHPAKARSKE ELHRRDELKH NQRIQLEDLL DQHWNPKDTS
SDAGEGKGGY GLDHDKMDPQ WVLNATSQLG AKEWTEHRHH DDMEEGRDSS SVNGTTTAMD
IDMAQLDHEK SDGIEIRGDT LFNITEGNVS RGDRQQGSLS LSEEGDQETQ RQPTQTQSPS
LRTNTSKQQQ HGTNSSSEET KSREGANQRM EQRFHPTEEI NQRPESRFPP LEEAGQRRKD
NETPDSERRL QHALQLEQEK LEEERKELLL LHRRLDDEKE HLRREQQKQQ QEEEEQKYPR
PNHKHHQTQT TTQRTGAVSP ISTRAPSDLA RPRPPARPGP PRKRMRKNNR KRISKAAMRA
MLM
//
