ID A0A1S3S8K4_SALSA Unreviewed; 1427 AA.
AC A0A1S3S8K4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=G-protein coupled receptor 126-like isoform X5 {ECO:0000313|RefSeq:XP_014060677.1};
GN Name=LOC106607820 {ECO:0000313|RefSeq:XP_014060677.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014060677.1};
RN [1] {ECO:0000313|RefSeq:XP_014060677.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014060677.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR RefSeq; XP_014060677.1; XM_014205202.1.
DR OrthoDB; 3026989at2759; -.
DR Proteomes; UP000087266; Chromosome ssa06.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15996; 7tmB2_GPR126; 1.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF290; ADHESION G-PROTEIN COUPLED RECEPTOR G6; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_014060677.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1427
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010353254"
FT TRANSMEM 1036..1059
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1071..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1098..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1140..1162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1191..1217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1238..1260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1266..1289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..148
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1034..1290
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 521..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1362..1387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 93..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 1427 AA; 155484 MW; 072C86D8C7DA435F CRC64;
MESYIRGGWW RWKFRNVLPV ALLWMSLQRQ AVLSCSNSNC VVVLKDSQGA FTSPCYPQDY
PSSQACKWTL QAPAGFIVQI TFLDFELEEA LGCIYDRIIV NTGNQDVKFC GLTANGLTLN
STGNVMEVSF NSDFSVQKKG FSVSYRQVAV ALRNQKVTVS NGAGKVVQVS NSVTIPTLQQ
FTVCFEIAQP NQKSKETIFS YTRQEDSSGE EALSFGNNQN GVALVMSNET CLIDSILNAS
DFTSTMKQFC LTWASTTGKV TLYYNSNYSV KTCSNTIGRS VGAGGLFRLG SHSSFDGTIY
NFRLWDYAMD RTQLVALTCD AVGNVIDWDN SFWDIPSSLA QTDSALSCST SVPVYTSQIT
SCASPGLGCP ATLTSTSSSI VTTNMIATNS TTHALSATTS SATTTSMPLT TSSSTATLTS
TSSSIVTTNM IATNSTTHAL SATTSSATTT SMPLTTSSST VQTTTTTTTA ATTNVPTLPS
TTTVTQTIIP SAAAATNTTL FYSTTNALTA SATTIVSNPA TTNLPTTNNT ARVTTTPPLS
PTTNTPANIT TTPVSNATTT PPSSTNMSPT VMSTNIIKLE GLFYRISFVV NDKEAKLTES
DVEKTVAQWL NQTFQNWTHV VYVDNFSIQP NSDSQLKRSA SKKYTCQALL VYQTSTNVTL
GEVAISTRVV GRSTNIGNGL ELETVAVQSV ENCPEETPLH YIWPESRPTV TQYVPCFPNK
DQNTSRTCVI SPLNYTAFWG APDLSNCTDI DSINVSAENA AEVADQLADI TNNELSTDEV
SKVVDKVKEL VNVAKINTTL ATTVLNIISN VMTSSVSALA VASERTLKTV DELVQKLEFD
GPSVSITSKN LALGISTLNH GKFNGTSFSA FIQPNTTDLQ IDFESNQLNP LAQVTLPATL
LKNLTDAETA AISRINFMFF SKIGLFQDKQ DGLSLNSYVV ASSVGNYSIS NLQDPVEIEI
LHLNYQPKPK PTCMFWDFIM KNGSGGWNSK GCRVSPMSNG NKTICLCDHL THFGILMDIS
GSAAQIDEKN TKILTFITYI GCGISAIFSA VTLLTYIAFE KLRRDYPSKI LMNLSTSLLF
LNMVFLLDGW LASFEMEGLC VAVAVFLHFF LLTSFTWMGL ESIHMYIALV KVFNTYIRRY
ILKFCIVGWG LPAAIVATVV AIDKNSYGKM EYGKGETGQG SSEFCWIRSH VVFYVTCVGY
FCVIFLLNVA MFIVVMIQIC GRNGKRSNRT LREEVLRNLR SVISLTFLLG MTWGFAFFAW
GPVNLAFMYL FSIFNSLQGL FIFIFHCALK ENVQKQWRRY LCCGRFRLAD NSDWSKTATN
NTKKVSSDTV GKSLSSSSFG SSTANWTSKA KATLNPFAKR NSNAGKGYSN QTNLKSVSSD
GEASSSSSSI IPVHQVIDKV KGYCSARSDN FYKNIIMSDS FSHSTKF
//
