ID A0A1S3S9G9_SALSA Unreviewed; 1637 AA.
AC A0A1S3S9G9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Pleckstrin homology domain-containing family G member 1 isoform X1 {ECO:0000313|RefSeq:XP_014060983.1};
GN Name=plekhg1 {ECO:0000313|RefSeq:XP_014060983.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014060983.1};
RN [1] {ECO:0000313|RefSeq:XP_014060983.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014060983.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014060983.1; XM_014205508.1.
DR STRING; 8030.ENSSSAP00000017381; -.
DR PaxDb; 8030-ENSSSAP00000017381; -.
DR Ensembl; ENSSSAT00000018464; ENSSSAP00000017381; ENSSSAG00000008287.
DR GeneID; 106607972; -.
DR KEGG; sasa:106607972; -.
DR OMA; WHSTYSN; -.
DR OrthoDB; 5400510at2759; -.
DR Proteomes; UP000087266; Chromosome ssa06.
DR Bgee; ENSSSAG00000008287; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13243; PH_PLEKHG1_G2_G3; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043324; PH_PLEKHG1_G2_G3.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 1; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 182..362
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 386..485
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 15..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1162..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1427..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1098
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1427..1454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1463..1508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1565..1596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1637 AA; 180915 MW; DB5D5534EC88BB00 CRC64;
MKNSFSPVRV NNFSRTGCRR LGRPKKANDY TDALPPLPEI PDAGSVLSSV GVPGRFRHTD
IHHTPLRYCS AHSMDSSPDS AERPISYGST SSSASSRDSH CSLGSRSTLG PSPHCHPAPD
QDSGAIRLEL VPARQLGCGD EEERNIGGTD AGKGTVRLVS AQTPQSDTKA GERSSPGPRV
QYVDRVVQEI MDTERTYVLD LQSIVQDYLE CISNQSCLAL SSEERGSLFG NIRDIYHFNR
DLLHDLEKCN SDPVAIAECF VAKSEEFHIY TQYCTNYPRS VAVLTECMRN KALAKFFRER
QESLRHSLPL GSYLLKPVQR ILKYHLLLHE IANHLEKDTE TYEVVQEAID TMQRVAWHIN
DMKRKHEHAV RLQEIQSLLT NWKGPDLIGY GELVLEGTFR LQRAKNERTL FLFDKLLLVT
KKREEAFTYK AHILCCNLML VEIIPKEPLS FSVFHYKNPK LQHTVLAKSQ QDKRMWILHL
KRLILENHPA KIPAKAKQAI LEMDVMHHPG FHYSPDGDKR SPHTKEGSTP RRVRRKSEPL
SKLLKNAKHG VKEDGSKRTS LGATLLSPVS QLALGTIGRS RSLVNQSQES LDPGDHFDHS
DREDGEEPHQ QDADDEDDSG LGGGKRLRVP EKSSRKKLNQ QASMDSSIDQ WKTFNMSASD
LQRANKSLQG AHHPPLLRTP RVTEEPPDTH VPSMLVPGGD PQTVGNIWAD HRVRRAMFPT
RQRTMNPDEE DEDIYQMFVP TEPGGQEPEP LPVRLEVTSS PSKTQGRPCS WHMEQVPTVQ
IDPPSTGDSR MLRRASSVGE KQTGGRQSPP GQDDDQEGMI HAESSSNDIS GSSSAEQLTL
DDMENIYDNI SYEDLKSMGL IRREQEGRVA QREAPRDTQG PGALNTGVTG SITEPLMEPD
CLSDSNHSST TQEGVPFGTC ALKIVEEENI YDTICFRQPP AKGDRDRDIP AQERDSLLPS
ASEPDLTGCE SLGGFVSEES LHFGADEWTE DNSHPVHGTS EPDYYSSSAS ETFSQRSHTG
DQMSEQVDEI WNDLENYIKK NEKKADRLPA AFPVSASEAP KTSSVKSSPK KNSSQKHSSP
TKSPPARNPN PPTVTPPHQF TIPILNFPEL LREATFEDED HYPSPLTAPS LPLPAIPDPA
PSGTVKTIRN RLARLSSGSF RLEDDDELGD LPQRDPTQRD PSIRDLHSLF PGELAGLGGL
DSPLASSSLL PGDSVDSFSQ ELMDKTKNRV FLMARQYSQK IKKANQLLRM KSMDPGDMGS
GGRNREEKKQ QKDLEKKQKD LAAILEDKKQ GGAAIGARIA EYSQLYDQVM FKDPPGQGSS
SPGPPGSHHA HPGLASSPSL PETCSSLGLG LEDDWLLSTY SNGELASFVS EIRSSTPQCR
LTAACSVPTL KILPPSPETS PTQRWSSCVS APSEKEEHVY SSIKRHTSFN SASSSSSSSK
PPTSRCQSIC SLGDRQQEKE NELTGSNRGP AVVQSSSERL HCLSSLGRAG RQSSLPERSS
CGHGHSDLTL QDGQQVVVLN RASALSMLTA TQNYLANFKD KGDDDDDDYV EIRSEDESER
DQDCSGQRNN GGGGGGSRGP AQTQSLPCTP SRSSCGLTDR ERLQEYLWAE QPAQQNQPNI
VQSLREKFQC LSSSSFA
//
