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Database: UniProt
Entry: A0A1S3SB60_SALSA
LinkDB: A0A1S3SB60_SALSA
Original site: A0A1S3SB60_SALSA 
ID   A0A1S3SB60_SALSA        Unreviewed;      4845 AA.
AC   A0A1S3SB60;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   SubName: Full=ryanodine receptor 3-like isoform X4 {ECO:0000313|RefSeq:XP_014061575.1};
GN   Name=LOC106608253 {ECO:0000313|RefSeq:XP_014061575.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014061575.1};
RN   [1] {ECO:0000313|RefSeq:XP_014061575.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014061575.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   RefSeq; XP_014061575.1; XM_014206100.1.
DR   GeneID; 106608253; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_014061575.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4171   4192       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4392   4412       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4447   4473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4597   4622       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4645   4667       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4726   4749       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      105    160       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      167    212       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    274       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    335       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      346    403       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      606    804       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1020   1215       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1261   1469       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3926   3952       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3398   3418       {ECO:0000256|SAM:Coils}.
FT   COILED     3592   3612       {ECO:0000256|SAM:Coils}.
FT   COILED     4109   4136       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4845 AA;  548071 MW;  EF44A005690D587F CRC64;
     MAEGGEGEDD IQFLRTDDEV VLQSVATIQK ENRKFCLSVE GLGNRLCFLE PTSEAKYVPP
     DLCICCFILE QSLSVRALQE MLAHTVPNNE GKADHEQWAA QGGGHRTLLY GHAILLRHSF
     SGMYLTCLKT SRSLTDKLSF DVGLQEDSIG EACWWTIHPA SKQRSEGEKV RIGDDLILVS
     VSTERYLHLS ISSGSFQVDA SFMQTLWNVQ PTCSGSNVAV GFLCGGHVMH LCHGHDESLT
     IPGSEASEME QRIVNYEMGK GASRARSLWR LEPLRIGWSG SHIRYGQAFR LRHLSTGQYL
     ALTEEHGLVL QEREKSDTKS TSFCFRATKE KIESGTKNRD IEGMGVAEIK YGDSACFVMH
     VATGLWLSYQ APDAKASRIG PLKRRACLHA EGHMDDGLTL QRCQHEEARA VRIIRNTTVL
     FSHFIKGLDS IGRDKNVEVS LPNFDEVLQT LDDLIEYFKQ PDSELEHEEK QTLLRSLIKR
     QDLFKEEGML ALLVMCIDRL NLYNSAAHFG EHAGEEAGAA WKNILNLLYQ LLASLIKGNR
     NNCTQFSRNL DWLVSKLERL ESSSGILEVL HCILIESPEA LNIIQKGHIK SIISLLYKHG
     RNHKILDVLC SLCVCNGVAV RANQNLICDH LLPKRDLLLQ TRLVNDVQSM RPNIFLGVAE
     GSAQYKKWYF ELMIDQVNHY VTSEPSHLRV GWASTKGYAP YPGGGEGWGG NGVGDDLYSY
     SFDGLYLWSG RISRAVASIN QHLLNSDDVV SCCLDLGAPS MSFRINGQPV QGMFEDFNTD
     GFFFPVVSFS AGVKVRFLLG GRHGDFKFLP PAGYSPCYEA LLPKEKMRVE AVKEYKRDYG
     GVRDLLGTTQ FLSQASFIPT PVDTSQIVLP PHLDNVRDRL AENIHELWGM NKIELGWCYG
     KVRDDNKRQH PCLVDFTKLP ETERNYNLQM SSETLKTLLA LGCHVTQTNV NAEEDLKKVK
     LPKDYVMSNG YKPTPLDLSE VKLTAGHEVL VDKLAENAHN VWAKERIKQG WTYGIQQDVK
     SRRNPRLVPY ALLDERTKKS NRDSLREAIR TLVGYGYNID PPDQEPCHIV EKQSIETIRF
     FRVEQTYAVK TGKWYFEFEA LTGGDMRVGW ARPGCRSDFD LGMDDQAYVF DGYKGRRMHM
     GARFFGQSWN EGDVVGCMIN MEDKSMVFTL NGELLITNKG SELCFVDFET DDGFIPVCCL
     AQSEIGRMNL GKDASSFKYY TTCGLQEGFE PFAVNMNREV TMWFSKRLPT FVNIPKDHNH
     IEVTRIDGTV DNPPCLKVTH KTFGTQQSNS DMLYCRLSMP VELHAPHVSP DESQKLSQPP
     KEDDYGRITT YYHSVRVFAG QDPASVWVGW VTPDYHYHSK QFSLNKTRTV TVTLGDERGR
     VHESVRRSNC YMVCAGDVVG SSHSSSRSNI DLEIGCLVDL ATGFLSFTAN GKELATTYEV
     ESNTKLFPAV FVRPTSTNLF QFEFVKIKAA MPLSSAIFKS EQRNPVPQCP PRLDVQTIVA
     VLWSRMPNTF LTVETARVSE RHGWVVQCLE PLQMMAVHIP EENRCLDILE LSENEGLRKF
     HYHTLMLYCA LCALGNTRVA HALCSHLDQS QLLYTIDNQY LSGMLREGFY NVLMSIHLET
     AKEARLMMNN EFIIPVTDET RSIKLFPDES KRHSLPGVGL STSLKPRLIF SPLSFITTKK
     QQHLHSPQIP LGILKEKAIS MLTEAVQGGG SHIRDPVGGS VEYQFVPILK LIGTLLIMGV
     LTSEEVRLIL LLIDPNVFGE PEEEEVEAAS AGGGEKEEVS SNEEKAVEAG EEETKDVKPT
     VKGLLEKTLP ESVKRQMCEL LHYFCDCELK QRIEAIVSFS DSFVSKLQYN QKFRYNELML
     ALNMSAAVTA KKTKEFRSPP QEQINILLNF AAGEDCPCPE EIQEDLYKFH DELRLHCGIP
     VEEEEEEEDT SIKGRLLAML YKIKGPPKKL EEEPTEEEQA APTNLKELIS QTMASWAQEC
     SIQDPELVRV MFSLLRRQYD GIGALLRAMK KSYTISAVSV QDCVNLLASL GQIRSLLSVR
     MGKEEEKLMI DGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGGDK SQEIAFPKMV
     ASCCRFLCYF CRISRQNQKA MFDHLSYLLE NSSVGLASPA MRGSTPLDVA ASSVMDNNSL
     ALALEEPDLE KVVTYLAGCG LQSCAMLLAK GYPDIGWNPI EGERYLSFLR FAVFSNGESV
     EENSNTVVKL LIRRPECFGP ALRGEGGNGL LAAMLEAIKI SEDPALDLPS TADGEPSGSD
     EEEEVAHTGN AIMSFYSALI DLLGRCAPEM HLINKGKGEA LRIRAILRSL VPTTDLVGII
     SIPLKMPIVN KDGSVTEPDM SASFCPDHKA PMVLFLDRVY GVEDQSFLLH LLEVGFLPDL
     RASASLDTDV LSTTETALAM NRYIGSALLP LLTRCADQFS GTEHYAALID STLHTIYRLS
     KGRSLTKAQR DSIEECLLAI CKHLRPSMMQ QLLRRLVFDV PLLAEYCKMP LRLLTEHYEQ
     SWMYYCLPSG LGSSGMASEE ELLLTKKLFW GIFDSLSTKK FDSDLFKTAM ACLSAIAGAL
     PPDYMDASPG VTLEKQASVD AHGNFDPKPI NTANMSLPEK LDYIANKFAE HSHVKWSSEK
     VTAGWKMGEC VDDDAKTHPL LKPYKSLSEK ERETYRWPVK ESLKSMLAMG WNMERTKEGE
     AMLIRKQSKI SESTQDNDNE FIPEPPLDLN NITLSRELQG MVEVVAENYH NIWAKKKKAE
     LNSKGGGSHP LLVPYDTLTA KEKYRDREKV QDLFKFLQIN GYTITRGLKD MEQDSSSMEK
     RFAYTFLKRL LKYVDSAQEF IAHLEAMATS GKTDKSPHDQ EIKFFAKVLL PLIDMYFKNH
     SMYFLSSPSK NLSSSGYASN KEKEMITSLF CKMAALVRHR ISLFGSDSAI MVSCLHILAH
     SLDTRTVMKS GSEMVKAGVR TLFENAAEDL EKTLEMLKLG KFSQSRSQMK GLSQNITYAT
     TALLPILTAL FEHVTMHNFG VCLLVDDVQL SCYRIVTCLY SLGTGKHIFM ERHLPALGEC
     LATLVGAMPV AFLEPDLNAH NPLSVFNTKT QRERAILSMP DSVEEMCSDM PRLDRLLKDI
     NDISESGARY TEMPQVIEVI LPMLCNYLSY WWERGTENSA PHTACCTTVC SHHLSIILGN
     ILKILNNNLG IDDAPWMKRI AVYSQPIICK AAADLLKSHF LPTLEKLRKK TVKVVAEEEL
     LKADIKGDTQ EAELLILDEF AVLCRDLYAF YPMLIRYVDN NRSRWLKRPD AQSNELFTMV
     AEIFILWCKS HNFKREEQNF VVQNEINNLS FLTGEHKTKM SKSGGDQDRK HKKRRGELYS
     VQTSLIVAAL KKMLPIGLNM CTPGDQELIS LAKIRYSLKD TDDEVKDHLR ENLHLQDKSD
     DLAVQWQMNL YKDVVVVGSE EHADPEQTVD RIQSISAAVF HLEQVEQPLR MKKCVFQKLL
     SKQRKRAVVA CFRMAPLYNL PRHRSINLFV LGYVRLWIET EEYSFEERLV QDLAKTPMKI
     VEEEEEEEVE IQPDPLHQLI LHFSHNALTE RSFLEEDPLY IAYADMMAKS CAEDEEEEEE
     EEGKEKTFEE KEMEKQKILY QQARLHARGA AEMVLQMISA SKGRLGPMVT CTLKLGISIL
     NGGNVLVQQK MLDYLKEKRD AGFFKSLSGL MQSCSVLDLN AFERQNKAEG LGMVTDEGSS
     SKVLTNDDFT KDLFRFLQLL CEGHNGDFQN FLRTQTGNTL TVNIIISTVD YLLRLQESIS
     DFYWYYSGKD IIDEAGQVNF SKALAVAKQI FNSLTEYIQG PCIGNQQSLA HSRLWDAVVG
     FLHVFANMQM KLSQDSCQIE LLKELMDLQQ DMVVMMLSLL EGNVVNGTIG KQMVDTLVES
     SSNVEMILKF FDMFLKIKDL TTSDNFREYD PDNKGVISKK DFQKSMENQK QYTQSEIEFL
     LSCAEADEND MFNYEEFVER FHEPAKDIGF NIAVLLTNLS EHMPHDPRLA TFLEPAESVL
     NYFEPYLGRI EIMGGGKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGESEKM
     EMFVNFCEDT IFEMQLASQI SEPEVVERPE EEEEEVHNLL EELAEQEEER ELEASSAFTM
     VCVSAKKKIS NFREMLTFKS LKKQYKKSKK LSMKEVILGF FSFFWTLFAG FFKGIYSLIF
     GFFHLIWSSM FGGGLVEGAK NMKVTDILGN MPDPTQFGIH GDVLETEKVE VSDSVSGGTD
     QAIKPSDKAE QDILMEMINP MPKKGEGLKH VDPGLGDVSE NLTAETTATV EKKNAASEPT
     ESEPEKADTE KKEKEDKVKV EQPKEEMAQD KPVLKSRNGQ SKEAPTSFFA SFLAGLEVYQ
     AKMLNTLARN FYNMRFLALF VAFAINFILL FYRVTAAEDD EDDSWTSSDD EDEGGEEYFV
     LEESTGYMAP ILCFLAVFHT ALSILCLVGY YFLKVPLVVF KREKGIARLL EFEGLYITEQ
     PADDDIMGQW DRLVINTPSF PNNYWDKFIK RKVINKYGDL YGAERIAELL GLDKSALDFD
     PTQETVVEAA SLVSWLSSID TKYHIWKMGV VLTDNSFLYL IWYATMSILG HYNNFFFAAH
     LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT VVAFNFFRKF YNKSEDEDAP
     DMKCDDMMTC YLFHLYAGVR AGGGIGDELE DPAGDPYELW RILFDITFFF FVIVILLAII
     QGLIIDAFGE LRDQQEQVKE DMETKCFICG IGNDYFDTTP HGFETHTLQE HNLANYLFFL
     MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDLLG
//
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