ID A0A1S3SDA0_SALSA Unreviewed; 2086 AA.
AC A0A1S3SDA0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Dedicator of cytokinesis protein 11 isoform X2 {ECO:0000313|RefSeq:XP_014062324.1};
GN Name=dock11 {ECO:0000313|RefSeq:XP_014062324.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014062324.1};
RN [1] {ECO:0000313|RefSeq:XP_014062324.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014062324.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014062324.1; XM_014206849.1.
DR STRING; 8030.ENSSSAP00000120536; -.
DR PaxDb; 8030-ENSSSAP00000120536; -.
DR GeneID; 100380692; -.
DR CTD; 139818; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000087266; Chromosome ssa07.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF81; DEDICATOR OF CYTOKINESIS PROTEIN 11; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 164..271
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 654..831
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1632..2059
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 273..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2086 AA; 236757 MW; FAEF35F51E571E2C CRC64;
MSEVRKFTKR LSKPGTAAEL RQSVSEAVRT SVIVEQPKII EPLDYENVVF QRKAQIHSDP
HRDLLQCPVD DISESQISRQ RRTVVPSVPQ NAERDAKSLF AKECIKTYNT DWHVINYKYE
AYSGDFRMLP TKGLKMDKLP AHVFEIDEDA KDEDSSSLCS QRGGIMKQGW LQKANINSSL
SVSMRVFKRR YFYLSQLPDG SYILNSYKDE KNCKDTKGSI YLDSCIDVIQ CPKMRRNGFE
LKMQERYSHF LSADSEAEME EWVVTLKQAL QSSTEGGDRR NGGDSLDCAL DEDSSSQGKG
ESLLESLGRS LHPELIKYAR ETDQLNKMNR NEGRQKLFSL DPETQRLDFS GIEPDVKPFE
ERFGRRIAVS CHDLTFSLQG CANERGDGVL TNVEPFFISL ALFDVSKSCK ISSDFHVDLN
PPCVREMLTD TSPLSPTSEG GGGGGGVNGG VNGDAGKGNG LPVLQRVAES LLQYPTQGIF
SVTNPHADIF LVARVEKVLQ NGITHCAEPY IKTSDINKTA QKVLKAAKQT CQRLGQYRMP
FAWAAKQVFK DAQGSLDMDG KFSPLYRQDS SKISTDDLIK MLADIRKPEK SKLQTIPGQL
NVTIECVPPD FSNTVTSSYI PVKPFEEKCE RVSVEMEEFL PEEAKYNYPF TVYKNHLYVY
PLQLKYDNQK TFAKARNVAV CVQFRDSDEE GAAPLKCIYG KPGETLFTTS ACAAVLHHNQ
SPEFYNEVKI ELPVHVHEKH HILFTFYHIS CEISTKTSTK KREGVESLVG YSWAPLLKDG
RMQSIELQLP VSATLPPGYL YDKTQDAKKS APDIKWVENN KPLFKAKTNV ASTIYPQDLH
LHKFFQHCQL MRSSSEGNPA ELIKYLKCLH AMETKVIIKF LPTVLMQLFE VLNTATKEAT
EIAVNSTRVI IHIVSRCHEE GLENYLRSFL KYVFVNNSPV AGNSGTTHEV LATAVTAILK
QTADFNTSNK LLKYSWFFFE TMAKSMVQYL QEGNRIKMPR AQRFPDSFHQ ALQSLLLSIM
PHITIRHVEI PEEARCVNLS LAGFIKRCLT FMNRGFGFSL INDYMCGFTL KDPKVLTEMK
FDFLMTVCNH EHYIPLNLPM AFGRTKLQRV QDFISYATEI FGAVDQSLES ALTEDYCKNH
FLVGLLLREV AEALQGSPEV RQLAVAVLKN LLIKHAMDDR YTQYKNQARI CLLYLPLLEL
LYQNLKQLSA QHHTSSPGLG FTGSRDDLRS TGLMDSRRTS TAIDKDHGPV AQNGHLVRRE
DSRGSLFMDP STPDSSELHR RGSTMSSSTT LPPIGRLGHY EIKGLLLCFL HIVRTVSDDT
LLAYWNKVNP QDIINFLSLL ETCLVQFRYV GKRNIGRSQD AWVSKLFSSD RKSQTMPVMR
CRAGLMQSRL QQFSTMDTSL TLNIGTGPSE AEVHHQALLE GNISTEACLS VLDVLSHFTQ
CFKNQLLDSD GHNPLMKKVF DIYLNFLKVG QSEAALKHVF ASLRAFMNKF PAALFKGRVT
LCAALCYEVL KCCVSKMGLL RAEASALLYL LMRNNYEYTK RKTFLRTHLQ IIIAVSQLIS
DVALTGSSRF QESLSIINNF ANSDKAMKST AFPGEVKGLT KRIRTVLMAT AQMREHEKDP
EMLLDLQYSL ARSYASTPEL RRTWLDSMAR AHIKNGDLSE AAMCYIHVAA LVAEYLNRKK
MFPSGLAAFK RITLNIEEEA AMKEDTGMQD VYYTEEVLVE RLELCVEGLW KAERYELITH
VAKLIIPVYE KRHEFQKLSR LYDTLHRAYN KILEVMHTGR RLLGTYFRVA FYGQGYFEEE
DGKEYVYKEP KLTGLSEISQ RLLGLYGDKF GTESVKIIQD SNKVNPKDLD TKFAYIQVTF
VKPYFDEKDC PEKKTDFEKC HNINRFVFET PYTLTGKKHG GVEEQCKRRS VLTTANTFPY
VKKRVEVLGE KQVELKPVDV AIDEMRARTA ELTKLCSSQE VDMIQLQLKL QGCVSVQVNA
GPMAYARAFL DDSKTSKSNN KKAMELKEIF RRFVEVCSMA LDINERLIKE DQFEYHEGLK
GNFKDMVKEL SDIIHEQIFQ EDMMRSLLQN SLHVFRAISG TSTDLG
//
