ID A0A1S3SGG7_SALSA Unreviewed; 2751 AA.
AC A0A1S3SGG7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Filamin-C-like isoform X3 {ECO:0000313|RefSeq:XP_014063434.1};
GN Name=LOC106609299 {ECO:0000313|RefSeq:XP_014063434.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014063434.1};
RN [1] {ECO:0000313|RefSeq:XP_014063434.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014063434.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR RefSeq; XP_014063434.1; XM_014207959.1.
DR GeneID; 106609299; -.
DR OrthoDB; 298396at2759; -.
DR Proteomes; UP000087266; Chromosome ssa07.
DR Bgee; ENSSSAG00000046597; Expressed in muscle tissue and 12 other cell types or tissues.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21310; CH_FLNC_rpt1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 44..150
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 167..270
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 278..376
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 378..476
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 518..614
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 615..707
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 711..807
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 808..910
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 911..1009
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1010..1105
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1106..1198
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1199..1293
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1294..1393
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1394..1486
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1487..1582
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1583..1679
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1692..1783
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1801..1870
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1870..1962
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1960..2049
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2052..2144
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2273..2333
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2336..2428
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2430..2523
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2527..2619
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2656..2750
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..520
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2751 AA; 295602 MW; 1C7FFAD0F5DC8F19 CRC64;
MMSNNTYYEQ QQPPQYYQST DNGDDEEEMP ATEKDLAEDA PWKKIQQNTF TRWCNEHLKC
LNKRINDLQK DLTDGLKLIG LLEVLSQKKM YRKYHARPNF RQMKLENVSV ALEFLEREHI
KLVSIDSKAI VDGNLKLILG LIWTLILHYS ISMPMWEDED DEDAKKLTPK QRLLGWIQNK
VPQLPINNFH RDWRDGKALG ALVDNCAPGL CPDWETWDPS QPVENAREAM QQADDWLGVP
QVIAPEEIVD PNVDEHSVMT YLSQFPKSKL KPGAPLRSKT LHPKKAKAYG PGIEPRGNMV
LKPAEFIVET VEAGLGEVLV YVEDPEGHTE EARVIPNNDK NRTYSVIYLP KVEGLHKVKV
LFAGQDIDRS PFVVSVSKAM GDPNKVQARG PGLEPVGNVA NKPTYFDIYT AGAGAGDVGV
IIVDSQGRRD TVEIILENKG DSIFRCTYCP ILEGSHVIYV TFAGQQIPRS PFTVHISEAP
PSSLPPGSPV QIVPQSIRTP PTDKAKRVPP PTPPKPRRPT SNPNVCRASG RGLQPKGVRV
KEVADFKVYT KGAGSGELKV TVKGPKGLEE PVKVRDAGDG VYECDYYPIR TGKYTITITW
GGQTIPRSPF EVVVSEDVGP QKVRAWGPGL ETGMVGKSAD FVVEAIGTEV GTLGFSIEGP
SQAKIECDDK GDGSCDVRYW PTEPGDYAVH VICDDEDIKD SPFMAHILLT ANDVFPAKVK
SYGPGLEPIG CIVNKPAEFT IDTSRAGRGQ LKIYAQDAEG FPIDIQITEN GDSTFLCVYI
PTKPIKHTII ITWGEVNVPN SPFRVTIGEG SHPENVKVYG PGVEKSGLKA NEPTYFTVDC
SEAGQGDVSI GIKCAPGVVG PAEADIDFDI IKNDNDTFTV KYMPPGPGRY TIMVLFADHE
IPISPFRIKV DPSHDANKVR AEGPGLNKTG VEVGKPTHFT IYTKGAGKAK PEVHFTGAAK
GDAVRDFETI DNHDYSYTVR YTAVQQGNMS ISICHGGDPI PKSPFNITVA PPLDLNKVKV
QGLNNKVDVG KDQEFTVNTH GAGGQGKLDV KITSPSRRPI PCKLESDTAN EVHTVKYIPL
EEGPYKVDIS YDGNPVPGSP FTVEGVMPPD PSKVRAYGPG LQGGMVGKPA PFAIDTKGAG
TGGLGLTVEG PCEAKIECQD NGDGSCSVSY LPTEPGEYAI NILFAEQHIP GSPFKAMVQS
MFDPSKVTAS GPGLERGKVN EAGSFVVDCS KAGDAELTIE IISDSGSKVE VHVQNNSDGT
YSITYIPQFH GMYTITIKYG GHAVPKFPAR VQVDPAVDTS GVKVYGPGVE PRGVLREVTT
HFIVDARAKS KTGGSHVKAR IVNPSGANTD AYITDKGEGT YRVEYTAYED GMHLIEVLYD
DVAVPNSPFR VPVMEGCDPS RVRAYGPGLE EGLVNKPNRF TVETRGAGTG GLGLAIEGPS
EAKMSCKDNK DGSCSVEYIP FTPGDYDVNI TFGGLPIPGS PFRVPVRELV DPSKVRCSGP
GLGSGVRAHV PQTFTVDTSK AGLAPLGVVL YGPTGVAEPV NITDNGDGTH TATYTPAKDG
PYTVCVKYAD QEVPRSPYKI KTLPAHDASK VRASGPGLNA QGVPASLPVE FTIDARDAGE
GLLTVQILDP EGKPKKANIR DNRDGTYTVS YVPDMAGRYT ITIKYGGDEI PYSPYRIHAL
PTGDASKCLV TVSIGGHGLG SGLGPTIQIG EETVITVDAK AAGKGKVTCK VSTPDGAELD
VDVVENSDGT FDIYYTAPEP GKYVITIRFG GEHIPNSPFH VVATEEPVTP GDIMEPMLRP
FNLVIPFTVQ KGEITGEVRM PSGKTARPNI TDNKDGTVTV KYAPTEKGLH EMDIKYDGNH
IPGSPLQFYV DAINSGHVTA YGPGLSHGMV NKPATFTIVT KDAGEGGLSL AVEGPSKAEI
NCKDNKDGTC TVSYLPTVPG DYNIIVKFDN KHIAGSPFTA KITGDDTMRT SQLNVGTATD
VSLKISETDL SSLTASIRAP SGNEEPCLLK RLPNRHIGIS FTPKEVGEHV VSVKKNGTHV
TNSPFKIMVG QSEIGDASKV KVFGQGLVEG HIFEVAEFIV DTRNAGYGGL GLSIEGPSKV
DINCEDVEDG TCKVTYCPTE PGNYIINIKF ADQHVPGSPF TVKVCGEGRV KESITRKRHA
PSIATVGSTC DLNLKIPGNW FQMVSAQERH TRTFTRSSHT YTRTERTEIS KTQAGETKRE
VRVEESTQVG GDPFRDVFGE FLGSQSLTGF SGIPATTRQP QEGVCVTQEG DQGIQEMTAQ
VTSPGGKTED AEIIDGEDST YSVRFIPQEM GPHTVNVKYR GQHVPGSPFQ FTVGPLGEGG
AHKVRAGGTG LDRGVAGMAA EFSIWTREAG AGGLSIAVEG PSKAEISFED RKDGSCGVAY
VVQEPGDYEV SIKFNDEHIP DSPFIVPIAT LSDNSRRLTV TSLQEMGLKV GQEASFAVQL
NGARGLVDAK VHTPSGAVEE CYVTELDSDQ HAIRFIPREN GVHSIEVRFN GSHIPGSPFK
IRVGEIGQVG DPGMVSAFGP GLEGGTTGAA SDFVVNTCNA GSGALSVTID GPSKVKMDCQ
DCPEGYKVTY TPMAPGSYLI TIKYGGPSHI VGSPFKAKVT GARLSGGHSL HETSSVLVET
VTKTSSSSMG VAYGPKFSSD ASKVVSRGAG LSKAFVGQKN TFTVDCSKAG TNMLMVGVHG
PKTPCEEVYV KHLGNRMYNV TYTVKEQGNY ILIVKWGDEN VPGSPFHVTV P
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