ID A0A1S3SGW4_SALSA Unreviewed; 558 AA.
AC A0A1S3SGW4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Neuroepithelial cell-transforming gene 1 protein-like isoform X3 {ECO:0000313|RefSeq:XP_014063582.1};
GN Name=LOC106609352 {ECO:0000313|RefSeq:XP_014063582.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014063582.1};
RN [1] {ECO:0000313|RefSeq:XP_014063582.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014063582.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_014063582.1; XM_014208107.1.
DR AlphaFoldDB; A0A1S3SGW4; -.
DR Ensembl; ENSSSAT00000122789; ENSSSAP00000088774; ENSSSAG00000069800.
DR GeneID; 106609352; -.
DR OrthoDB; 24012at2759; -.
DR Proteomes; UP000087266; Chromosome ssa07.
DR Bgee; ENSSSAG00000069800; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF4; NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 123..305
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 335..450
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 68..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 62214 MW; 36E5435A6AFFED37 CRC64;
MVAYDVLGSL VPIKRTLQAI DCQNQANKDS EEPSNKRVRP LGRVSSLANL ISPVRNGAVR
RFGQTIQSMS FRGDGNGGKT PGVPQKPCSK AVAPTPPKRR NSTLWSETLD VHQKGTFSTK
EIKRQEAIFE LTRGEQDLIE DLQLARKAYH DPMLKLSIMS EEELTHIFGD LDAYIPLHED
LLAQLARATG PDGTVGQIGQ IVVSWLPGLN AYRDYCSNQV AAKALLDQKK QDRRVQDFLQ
RCLESPFSRK LDLWSFLDIP RSRLFKYPLL LKEILKHTAP EHPDTPHLEL AITIIQGVLS
DINMKKGESE SQYYIDKLEY LDDRQRDPRI DQCKSLLCHG ELRNKSGTKL HVFLFTELLV
MTRSVTRNEH HCFQVYRQPI PVQDLVLEDL QDGDVKMGGS FRGAFSNSDK AKNIFRVRFH
DPSQGQSHTL QVNDVFHKQQ WLNCLRSAIS VHHPADAAVT TPASSPAADA HSKRHSSKIS
SIIHTEEADE NCPLTPAGAM SASSSLCGDE TPSPTSTSPS SRSSSSSSSP QSSPSPKHKT
KKDKRSLCAL GKRKETMV
//
