ID A0A1S3SJJ4_SALSA Unreviewed; 656 AA.
AC A0A1S3SJJ4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 1 {ECO:0000256|ARBA:ARBA00040433};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE AltName: Full=Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase {ECO:0000256|ARBA:ARBA00042914};
DE AltName: Full=Hemin-sensitive initiation factor 2-alpha kinase {ECO:0000256|ARBA:ARBA00042456};
GN Name=LOC100195543 {ECO:0000313|RefSeq:XP_014064499.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014064499.1};
RN [1] {ECO:0000313|RefSeq:XP_014064499.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014064499.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001127};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990;
CC Evidence={ECO:0000256|ARBA:ARBA00001127};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001416};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609;
CC Evidence={ECO:0000256|ARBA:ARBA00001416};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. GCN2 subfamily. {ECO:0000256|ARBA:ARBA00037982}.
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DR RefSeq; XP_014064499.1; XM_014209024.1.
DR AlphaFoldDB; A0A1S3SJJ4; -.
DR STRING; 8030.ENSSSAP00000001246; -.
DR PaxDb; 8030-ENSSSAP00000001246; -.
DR GeneID; 100195543; -.
DR KEGG; sasa:100195543; -.
DR CTD; 27102; -.
DR OrthoDB; 8734at2759; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR Bgee; ENSSSAG00000000739; Expressed in spleen and 16 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006446; P:regulation of translational initiation; IEA:UniProt.
DR CDD; cd14049; STKc_EIF2AK1_HRI; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11042:SF136; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1; 1.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR Pfam; PF00069; Pkinase; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000313|RefSeq:XP_014064499.1};
KW Kinase {ECO:0000313|RefSeq:XP_014064499.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Protein biosynthesis {ECO:0000313|RefSeq:XP_014064499.1};
KW Protein synthesis inhibitor {ECO:0000256|ARBA:ARBA00023193};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000313|RefSeq:XP_014064499.1}.
FT DOMAIN 187..610
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 269..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 617..644
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 279..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 217
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 656 AA; 73322 MW; 2D9F00DBE7FC909A CRC64;
MFSSLNGQRG VSPSSSSVIN SLIHRNLTTT TTGHECSVFN LTTSEDDDEV IFDTSDSDNN
CEVLITGKQY LSIQEFASAI PNHLLLGSLL EHLCFVYESD PTRSRMLFKV IGQRLAAMNL
LSPLAISDEF STVRLQHNRA FIELLDAAST SLFPQGQRLC NTDSQSLTLR PTEGLFQAQT
SRYLSEFEEL SRLGKGSYGK VFKVTNKLDG QKYAVKKILI KNVSREDCMK VLREVKVLSS
LQHVNVVGYH TAWMEHVAPA FINPASTLPA PETPALPERT EESTGSSNSS SIVFESSDHS
KEPVAIAKVP EILRVKALAP KEKSTQAVCP KTMRHTHVSE NFVPCVFLGR RGLTPDGCPV
VSWDGSALSE EASGTRNRME PNNNSYIDVG SEEWDTKCPT KEVQFHLMLY IQMQLCERSL
KDWISERTTE HISQNPYGSV DTKQTLSILH KILEGVEYIH SRSIMHRDLK PRNIFLHGLD
CHVRIGDFGL ACRDIIIDDD AKPTSTSQNT GSSHTTGVGT FVYAAPEQLE GSHYDSKSDM
YSIGVMALEL FQPFGTEMER VRTLGDLREG KVPDSFSQCW PLLAKYITLL TSRDPSLRPS
ATQLLQSELF SSKDMVIHGL QRRVEEQEEE IVRLRRQISQ LQTQSTQQAS HPTDKT
//
