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Database: UniProt
Entry: A0A1S3SKF3_SALSA
LinkDB: A0A1S3SKF3_SALSA
Original site: A0A1S3SKF3_SALSA 
ID   A0A1S3SKF3_SALSA        Unreviewed;       414 AA.
AC   A0A1S3SKF3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   SubName: Full=glycine receptor subunit alpha-3-like isoform X3 {ECO:0000313|RefSeq:XP_014064823.1};
GN   Name=LOC106610166 {ECO:0000313|RefSeq:XP_014064823.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014064823.1};
RN   [1] {ECO:0000313|RefSeq:XP_014064823.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014064823.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   RefSeq; XP_014064823.1; XM_014209348.1.
DR   GeneID; 106610166; -.
DR   OrthoDB; 614790at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0016594; F:glycine binding; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0022824; F:transmitter-gated ion channel activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR008127; Glycine_rcpt_A.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR01673; GLYRALPHA.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR608127-52,
KW   ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_014064823.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   TRANSMEM    205    227       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    268    291       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    386    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        5    203       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      210    296       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      309    365       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    334    352       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   SITE        244    244       Important for obstruction of the ion pore
FT                                in the closed conformation.
FT                                {ECO:0000256|PIRSR:PIRSR608127-51}.
FT   DISULFID    121    135       {ECO:0000256|PIRSR:PIRSR608127-52}.
FT   DISULFID    181    192       {ECO:0000256|PIRSR:PIRSR608127-52}.
SQ   SEQUENCE   414 AA;  47212 MW;  145567911200F815 CRC64;
     MGRTSGYDAR IRPNFKGPPV NVSCNIFINS FGSIAETTMD YRVNIFLRQK WNDPRLAYTE
     YPDGSLDLDP SMLDSIWKPD LFFANEKGAH FHEVTTDNKL LRIFKNGNVL YSIRLTLTLS
     CPMDLKNFPM DVQTCIMQLE SFGYTMNDLI FEWQENGPVQ VADGLTLPQF IMKDETDLRY
     CTKHYNTGKF TCIEVRFHLE RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVALGI
     TTVLTMTTQS SGSRTSLPKV SYVKAIDIWM AVCLLFVFSA LLEYAAVNFV SRQHKELLRL
     RPRRTKKKDD DVRESRLSFT ATTGGGGTAV KDGTIPKATN NTATTLGAAG PQPTQQPKKD
     PAAKSHEEMR KLFIDRAKKI DTVSRAGFPL AFLFFNIFYW VLYKILRAED VHKD
//
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