ID A0A1S3SL18_SALSA Unreviewed; 1050 AA.
AC A0A1S3SL18;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Probable E3 ubiquitin-protein ligase HERC3 isoform X2 {ECO:0000313|RefSeq:XP_014065038.1};
GN Name=LOC106610289 {ECO:0000313|RefSeq:XP_014065038.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014065038.1};
RN [1] {ECO:0000313|RefSeq:XP_014065038.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014065038.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014065038.1; XM_014209563.1.
DR AlphaFoldDB; A0A1S3SL18; -.
DR STRING; 8030.ENSSSAP00000038737; -.
DR PaxDb; 8030-ENSSSAP00000038737; -.
DR OrthoDB; 5475808at2759; -.
DR Proteomes; UP000087266; Chromosome ssa08.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF58; HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 5.
DR Pfam; PF13540; RCC1_2; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 1..52
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 53..102
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 103..155
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 156..208
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 209..260
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 261..312
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 314..380
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 723..1050
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 1018
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1050 AA; 116419 MW; 49F7A32E1DE9EF85 CRC64;
MMLCWGSTVE GQLGIGGARD PVCEPRSCQA FNGRGLKEVA CGGRHSLFLL RDGRVYTCGS
NRCGQLGHDK PGDSPELVVA LDTQKIGVVS CGQAHSMALN EQGQVFAWGA GGGGQLGLGT
AEETVPIPRL IKKLCEHRIS QIMCGNKHCI ALSKDGQLFT WGQNSSGQLG LGKGEPSTLS
PQPLKSLSGI PLAQITAGGD HSFALSLSGA VFGWGKNSAG QLGLNDKQDR SVPCHIKFLR
SQKVVYISCG DEHTAALTKD GGLFTFGDGS RGQLGHDSTN NEPLPRQVQE LMGSEVSQIA
CGRHHTLAFV PSSGLVYAFG CNTNGQLGTG TRGDIKSPLP VKSSLTGRLT GSPRHMSGPD
HYAITKINCG GDHNFLLYSD DKSSTAPEDF RVTNISRSIS LINDASLNTW RMKLLDNTDS
TITNDVILLL SSAACWNASF LDESDDSHFK TNPKVPGIDL NSVRLLFETL SKPPFARLLE
QATKSFESLL IPQLPCSPPD VEAMRIYLIL SECPALHDSK NYITLTIPLA MAILRLDANP
SKVLDNWWCL VDGGVFSRLV DMYKSIVVFL LTGGKALLVP VFLENYTSAT LMLLEKLHKV
NLKAGHVEYN RFYIPDITTL VDIQEDYLKW FLSKAEIKMR TPAVQSSVTL CAYPFILNAQ
AKTTMLQTDA ELQMQMAVSG ANMHNVFMLL TLEPLLARNP FLVLHVRRDH LVSDALRELT
IYSDVDLKKP LKVIFDGEEA VDAGGVTKEF FLLLLKELMD PVYGMFTQYT QSNLLWFSDK
CFVEHNWFNL IGIICGLAIY NSTVVDLHFP LVLYKKLLGV APTLEDLKEL SPTEGRSLQQ
LLDHEEDDVE ETFCLNFAIT REYYGLTEVK ELIPGGDRIT VDKNNREEFV EAYLKYMFRD
SVSELYQAFS SGFLKVCGGK ILSLFQPSEL MAMVVGNNNY NWEEMEKNAV YKGEYSATHP
TVRMFWEVFH EFPLEKKKRF LLFLTGSDRI PIHGMESLRI SIQSTSAEEH YLPVAHTCYN
LLDMPRYQTK ETLHRRLTQA VEQYEGFSLV
//
