ID A0A1S3SMT0_SALSA Unreviewed; 1250 AA.
AC A0A1S3SMT0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Unconventional myosin-VI {ECO:0000256|ARBA:ARBA00015382};
DE AltName: Full=Unconventional myosin-6 {ECO:0000256|ARBA:ARBA00030027};
GN Name=LOC106610693 {ECO:0000313|RefSeq:XP_014065653.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014065653.1};
RN [1] {ECO:0000313|RefSeq:XP_014065653.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014065653.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cell projection, microvillus
CC {ECO:0000256|ARBA:ARBA00004105}. Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|ARBA:ARBA00004132}. Golgi apparatus, trans-Golgi
CC network membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004150}. Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004600}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_014065653.1; XM_014210178.1.
DR AlphaFoldDB; A0A1S3SMT0; -.
DR STRING; 8030.ENSSSAP00000015541; -.
DR PaxDb; 8030-ENSSSAP00000015541; -.
DR GeneID; 106610693; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000087266; Chromosome ssa09.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd21759; CBD_MYO6-like; 1.
DR CDD; cd22294; MYO6_MIU_linker; 1.
DR CDD; cd01382; MYSc_Myo6; 1.
DR CDD; cd21958; MyUb_Myo6; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR049016; MYO6_lever.
DR InterPro; IPR032412; Myosin-VI_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR036114; MYSc_Myo6.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF745; UNCONVENTIONAL MYOSIN-VI; 1.
DR Pfam; PF21521; MYO6_lever; 1.
DR Pfam; PF16521; Myosin-VI_CBD; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 2..53
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 57..770
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 650..672
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 933..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 151..158
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1250 AA; 144798 MW; FA0BAEAB51E2814B CRC64;
MEDGKPVWAP HPTDGFQLGM IVDIGAGVLT IEPFNRKGKT FLASMNQVFP AEEDVNKHME
DNCSLMYLNE GTLLNNVRVR YSKDKIYTYV ANILIAVNPY NDIPKLYAPE TIKSYQGRSL
GTLPPHVYAI ADKAYRDMRV LKMSQSIIVS GESGAGKTEN TKFVLRYLTT SYGTGQDIDE
RIVQANPLLE AFGNAKTVRN NNSSRFGKFV EIHFNEKNKV VGGFVSHYLL EKSRICMQSK
EERNYHIFYR LCAGASEDIR QRLHLDSPDS FRYLNRGCTR YFASKDTDKQ IMQNRKSPEH
VKLGALKDPL LDDQGDFNRM CGAMKKIGLD DTEKLDLFRV VAGVLHLGNI DFEETGSTSG
GCILMNQSSQ KLAYCADLLG LDQEDLRVSL TTRVMLTTAG GAKGTVIKVP LRVEQANNAR
DALAKAVYSC LFDHVVRRVN QCFPFKTSSN FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL
QQFFNERILK EEQELYQREG LGVNEVHYVD NQDCIDLVEA KLVGILDILD EENRLPQPSD
HHFANTIHSQ HKDHFRLTVP RKSKLAVHRN VRDDEGFIVR HFAGAVCYET IQFVEKNNDA
LHMSLESLVC ESKDKFVREL FENSNNSKDS KQKAGKLSFI SVGNKFKTQL NLLLEKLRST
GSSFIRCVKP NLKMVSHQFE GAQILSQLQC SGMVSVLDLM QGGFPSRAPF HELYNMYKQY
MPDKLTRLDP RLFCKALFKA LGLNENDYKF GLTRVFFRPG KFAEFDQIMK SDPDHLAELV
KKVNQWLVIS RWKKVQWCAL SVIKLKEKMK YRASALIKIQ KTVRMWLCKR KHKPRIDGMV
KVRNLKTRME RFNEVVGALK EGKQEMAKQI QELGASIDTL MAKIKATVMT RKEIDQEYQG
LVKRSEQLLS SMQKKKQEEE EMERLRRIEE EMAQERRRRE EEDQRRQKEE DDRRMKLEME
HKRKQEEEER KRREEEERIM QAEMDIQIAL EREEDAQRSA MLEQEKRDRE LAMRIAQSEA
ELITDEALMD LSLRRGPQVQ ALKAAGVRKY DLSKWKYAEL RDVINTSCDI ELLAACREEF
HRRLKVYHAW KSKNKKRDTA TEQRAPKSIT DYAQQNPAPA VAAQQQEIAM NRQQRYFRIP
FIRPGDQYKD PQNKKKGWWY AHFDGPWIAR QMELHPDKQP ILLVAGKDDM EMCELSLEET
GLTTKRGAEI LPRQFEEIWE RCNGIMYLRS AIESRQARPT YATAMLQNLL
//