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Database: UniProt
Entry: A0A1S3SNL0_SALSA
LinkDB: A0A1S3SNL0_SALSA
Original site: A0A1S3SNL0_SALSA 
ID   A0A1S3SNL0_SALSA        Unreviewed;      4898 AA.
AC   A0A1S3SNL0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   SubName: Full=ryanodine receptor 3-like isoform X5 {ECO:0000313|RefSeq:XP_014065932.1};
GN   Name=LOC106610839 {ECO:0000313|RefSeq:XP_014065932.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014065932.1};
RN   [1] {ECO:0000313|RefSeq:XP_014065932.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014065932.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   RefSeq; XP_014065932.1; XM_014210457.1.
DR   GeneID; 106610839; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_014065932.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4198   4219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4439   4459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4507   4526       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4650   4675       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4698   4720       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4779   4802       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1276   1483       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3953   3979       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     2979   2999       {ECO:0000256|SAM:Coils}.
FT   COILED     3422   3442       {ECO:0000256|SAM:Coils}.
FT   COILED     3549   3574       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4898 AA;  555192 MW;  C9C94B8DB5D548B8 CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCVACIHK ENRKFCLTAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE QSLSVRALQE MLAKTGQNSE GAAQGGGHRT LLYGHAILLR HSFSAMYLTC
     LKTSRSQTDK LSFDVGLQQD STGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSSERYL
     HLSISNGNIQ VDASFMQTLW NVHPTCSGSN VEEGYLLGGH VLRLFHGHDE VLTIPGSDQS
     DQQQRIVNYE TGNAGAKARS LWRLEPLRIS WSGSHIRWGQ PFRLRHLTTG HYLSLTEERG
     VVLQDREKSD TSSTAFCFRA SKEKLESSPK RDIEGMGMAE IKYGDSICFV MHVATGLWLS
     YQAPDVKSSR LGPLKRRACL HSEGHMDDGL TLQRCQHEES RAARIIRNTT RLFSHFIRDL
     DCLGGKNRAS VALPIEEVLQ TLNDLITYFQ VPNAELEHEE KQIMLRSLKN RQNLFKQEGM
     LTLVSCCIDR LNVYNSAAHF GECAGAEAGA SWKDILNLLY ELLAALIRGN RNNCTQFSNN
     LDWLVSKLER LESSSGILEV LHCILIESPE ALNIIQRGHI KSIISLLYKH GRNHKILDVL
     CSLCVCNGVA VRANQNLICD HLLPKRDLLL QTRLVNDVQS MRPNIYLGMS EGSAQYKKWY
     YELMIDQVDH FLTSDPSHLR VGWATNKGYA PYPGGGEGWG GNGVGDDLYS YGFDGLHLWS
     GRISRAVASI NQHILTSEDV VSCCLDLGAP SISFRINGQP VQGMFENFNI DGLFFPVVSF
     SAGVKVRFLM GGRHGDFKFL PPSGYAPCYE ALLPKEKMKV EPVKEYKRDM EGVRDLLGTT
     QFISQASFIP TPVETSQIVM PPYLEKVRDR LAENIHELWA MNKIELGWSY GKIRDDNKRQ
     HPCLVDFPRL PETEKNYNLQ MSTETLKTLL ALSCHVVQVN ANAEEDLKKI KLPKNYMMSN
     GYKPTPLELS DVKLTPGQEL LVDKLAENAH NVWAKDRIKQ GWTYGIQQDV KSKRNPRLVP
     YSLLDERTKK SNRDSLREAI RTLIGYGYNI EPPDQEGGHA GDRLSIDKIR FFRVERTYAV
     MTGKWYFEFD VVTGGDMRVG WARPGCRPDV ELGTDELAFV FDGYKGQRLN MGSRFFGRCW
     HAGDVVGCMI NMEDKSMIFT LNGEILITNK GSELCFADFE TEDGFIPVCS LGLSQVGRMN
     LGKDASTFKY YTMCGLQEGF EPFAVNMNRE VTMWFSKRLP TFVNVPKNHN HIMVTRIDGT
     IDSPPCLKVS HRTFGTQNSN GDMVYCRLSM PVEFHSFFKT SPVMDMNGVH EDHESLKLKH
     RHPLKSMRHS HDGIRGTDYS NISTYHYSVR VFAGQDPSCV WVGWVTPDYH YYSNHFNLSK
     NRTVTVTLGD QRGRVHESVR RSNCYMVWGG DVTSSGHSSS RSNVDLEIGC LIDLATGLVT
     FTGNGKELAT SYQVEPNTKL FPAVFVRPTS PNLFQFELSK IKNAMPLSAA IFKSEHKNPV
     PQCPPRLDIQ TINSVLWSRM PNTFLKVETA RVSERHGWVV QCLEPLQMLA VHIPEENRCV
     DIMELSEQED LRKFHYHTLK LYCALCALGN TRVAHALCSH LDQSQLLYTI DNQYLSGMLR
     EGFYNILISI HLETAKEARL MMNNEFIIPI TTETRSIRLF SDASKHHSPP GVGLSTSLKP
     RLSFYPPCFI STRREQHLYS PQIPLDALKE KAITMLTEAV QGGGHHIRDP VGGSVEYQFV
     PILRLIGTLL TMGVLGSQDV HKILLLIDPN VFVEHSEEAV AVVMEATEKE GLTGTEEKAV
     EAGEEEAAKE AKLPMKGLLE KRLPEPVKRQ MCELLHYFCD CELKHRIEAI VSFSDSFVSK
     LQYNQKFRYN ELMLALNMSA AVTAKKTKEF RSPPQEQINM LLNFSTGEDC PCPEDIQEEL
     YAFHNELRLH CGIPMEEEED EQDTSIKGRL LALVYKIKGQ PLKTEEEPTE QEQQAPSNLK
     ELISQTMVSW AQECHVQDPE LVRVMFSLLR RQYDSIGELL RAMRKSYTIS AASIQDTINL
     LASLGQIRSL LSVRMGKEEE KLMIDGLGDI MNNKIFYQHP NLMRVLGMHE TVMEVMVNVL
     GGGKSQEIAF PKMVASCCRF LCYFCRISRQ NQKAMFDHLS YLLENSSVGL ASPAMRGSTP
     LDVAASSVMD NNGLALALEE PDLDKVVTYL AGCGLQSCPM LLDKGYPDIG WNPIEGERYL
     SFLRFAVFVN GESVEENSSV VVKLLIRRPE CFGPALRGEG GNGLLAAMKE AIKISEDLAL
     DLPSSAQGVS SDVSAEDDEE EEVVHMGNAI MSFYSALIDL LGRCAPEMHL INKGKGEALR
     IRAILRSLVP TEDLVGIISI ALKMPVIHKD GTVTEPDMAA SFCPDHKAPM VLFLDRVYGI
     EDQSFLLHLL EVGFLPDLRA SASLDTEVLS TTETALAMNR YIGSAMLPLL TRCAPHFAGT
     EHYATLIDST LHTIYRLSKG RSLTKAQRDA IEECLLAVCR YLRPSMLQQL LRRLVFDVPL
     LTEYCKMPLR LLTNHYEQSW KYYCLPSGWG SYGMASDEEL LLTKKIFWGV LDSLSQRKYD
     ADLFKMAMPC LSAISGALPP DYIDSTISTT LEKPASVDAQ GNFDPKPIST ANISLPEKLE
     NVANKYAEHS HDKWSAEKVM LGWKYGDCID EKAKTHPQLR TYKGLTEKEK EIHRLPVRET
     LKSMLAMGWN IDRTKDGETM SLRESEKMRK ISQSSSQGNS FNPTPIDTSN VVLSRQLQGM
     MEVVAENYHN IWAKKKKNDL GIRGGATHPL LVPYDTLTAK EKARDKEKAQ DMFRFLQING
     YAITRGLKDM EQDSSSMEKR FAYKFLKKLL KYVNSAQEFI AHLEAMATSG KTDKSPHEQE
     IKFFAKVLLP LIDQYFKNHC LYFLSSPSKN LSSSGYASNK EKEMVTSLFC KLAALVRHRI
     SLFGSDSTTM VSCLHILAHT LDTRTVMKSG SELVKAGLRT FFENAAEDLE KTLENLKLGK
     FTHSRSQMKG VSQNINYTTV ALLPILTALF EHITQHHFGV DLLLDDVQVS CYRILTSLYA
     LGTGKNIYVE RQLPALGECL ATLAGAMPVA FLEPLLNKHN PCSVFNTKTA RERAILGMPD
     AVEEMCPEMP RLDVLMKDIN DMSESGARYT EMPHVIEVVL PMLCNYLSYW WEKGPENQAS
     PHSGGSVCST TVTSEHLSLI LGNILKILNS NLGIDEASWM KRIAVYAQPI ISKARAVLLK
     SHFLPTLEKL KKKTVKVVSE EELLKADSKG DTQEAELLIL DEFAVLCRDL YAFYPMLIHY
     VDNNRSRWLK EPDADSNELF RMVAEIFILW CKSHNFKREE QNFVVQNEIN NLSFLTGDSK
     TKMSKSGGQD QERKHKRKRG EFYSIQTSLI VAALKKMLPM GLNMCTPGDQ ELISLAKTRY
     LLKDTDDEVK EHVRQNLHLQ EKSDDPAVRW QLNLYKDVMV KNEGPPDPER TVFRVQSISA
     AVFHLEQVEQ PLRSKKCVWQ KLLSKQRKRA VVACFRMAPL YNLPRHRSIN LFLLGYQRIW
     IETEMYSFEE KLVQDLAKTQ LKVEEEEEEE AEMQPDPLHQ LILHFSHNAL TERSSLEEDP
     LYIAYADMMA KSCAEDEEEE DEEGKEKTFE EKEMEKQKTL YQQARLHDRG AAEMVLQMIS
     ASKGTLGPMV TFTLKLGISI LNGGNILVQQ KMLDYLKEKG DAGFFKSLSG LMQSCSVLDL
     NAFERQNKAE GLGMVTEEGS INVSERGSKV LQNDEFTKDL FRFLQLLCEG HNNDFQNFLR
     TQTGNTTTVN IIISTVDYLL RLQESISDFY WYYSGKDIMD EAGQRNFSKA LAVAKQIFNS
     LTEYIQGPCI GNQQSLAHSR LWDAVVGFLH VFANMQMKLS QDSSQIELLK ELLDLQKDMI
     VMMLSLLEGN VVNGTIGKQM VDTLVESSSN VEMILKFFDM FLKLKDLTTS DNFKEYDPES
     KGVISKKEFQ KSMENQKQYS QSEIEFLLSC AEADENDMFN YEEFVKRFHE PAKDIGFNVA
     VLLTNLSEHM PHDARLATFL DLAESVISYF EPYLGRIEIM GGAKRIERVY FEISESSRTQ
     WEKPQVKESK RQFIFDVVNE GGESEKMELF VNFCEDTIFE MQLASQISEP DAVERPEEDD
     EDSQSVTEEP EEEEEESMME SHSAFTNSCV SMRKNLSSFR QLLTFKSMRR QYRRFRKMSV
     REMVQGFFSF FWMIIMGLFR FLYNLVWGFF HILWSSMFGG GLVEGAKNMK VTDILGNMPD
     PTQFGIHGDV LETEKMEASE ASSVAEMGHM GQGDKAEADL MAELLNIQTK SQGGKHAPEP
     GLGDMGEVVG VDAPSLASAV KQKKAKDSMC FLKEAATKEP TNGDHKAEPE KADPEDGEKK
     DQDKVKEEAP PEPLPEEKKA PKKRPGLKKE SPEEFMASFF SSLDIYQTKM LNYLARNFYN
     LRFLALFVAF AINFILLFYK VTGDDRDDDD PDPWNGGGAT DEEEDEGGME YFVLQESTGY
     MAPTLRFLAI LHTVISFLCV VGYYYLKVPL VVFKREKEIA RKLEFDGLYI TEQPSDDDIK
     GQWDRLVINT PSFPNNYWDK FVKRKVINKY GDLYGAERIA ELLGLDKSAL DFNPTEETVV
     KEASLVSWLS SIDTKYQCWK MGVVFTDNSF LYLVWYTTMS ILGHYNNFFF AAHLLDIAMG
     FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDD NQPDMKCDDM
     MTCYLFHMYV GVRAGGGIGD EIEDPAGDPY ELYRILFDIT FFFFVIVILL AIIQGLIIDA
     FGELRDQQEQ VKEDMETKCF ICGIGNDYFD TTPHGFETHT LQEHNLANYL FFLMYLINKD
     ETEHTGQESY VWKMYQERLW DFFPAGDCFR KQYEDQLG
//
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