ID A0A1S3SR21_SALSA Unreviewed; 2376 AA.
AC A0A1S3SR21;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN Name=LOC106611276 {ECO:0000313|RefSeq:XP_014066789.1,
GN ECO:0000313|RefSeq:XP_014066790.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014066789.1};
RN [1] {ECO:0000313|RefSeq:XP_014066789.1, ECO:0000313|RefSeq:XP_014066790.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014066789.1,
RC ECO:0000313|RefSeq:XP_014066790.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR RefSeq; XP_014066789.1; XM_014211314.1.
DR RefSeq; XP_014066790.1; XM_014211315.1.
DR STRING; 8030.ENSSSAP00000062123; -.
DR PaxDb; 8030-ENSSSAP00000062123; -.
DR GeneID; 106611276; -.
DR KEGG; sasa:106611276; -.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000087266; Chromosome ssa09.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21246; CH_SPTB-like_rpt1; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 9.
DR Gene3D; 1.20.58.60; -; 12.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF248; SPECTRIN BETA CHAIN, ERYTHROCYTIC; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 17.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 16.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 14.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 54..158
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 177..282
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 2213..2323
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1446..1466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2326..2376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 461..495
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1001..1028
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1570..1597
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2356..2376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2376 AA; 274429 MW; D942C8C20425D1D9 CRC64;
MTSTTDFDNV EITQQYSRIN TRFELLGEEL DNDNSSARLF ERSRIKALAD EREAVQKKTF
TKWVNSILCR VSCRISDLYL DLRDGRMLIK LLELLSGEKL PKPTKGRMRI HCLENVDKAL
QFLKEQRVHL ENMGSHDIVD GNHRLILGLI WTIILRFQIQ DIVVEMGQVD GTQRQSRTAK
DALLLWCQMK TAGYPNVNIT NFTTSWKDGM AFSALIHKHR PDLVDYSGLK RSNPTHNLQN
AFNVAEQTLG VTKLLDPEDV FTENPDEKSI ITYVVAFYHY FSKMKALAVE GKRVGKVLDH
AIETEKMIDK YETLSSDLLT WIQQTIIVLN NRKLANSLTG VQQQLQSFNS YRIVEKPPKF
QEKGNLEVLL FTIQSRMRAN NQRVYTPKEG ALVADLNRAW EHLERAEHER ERVLRDELIR
QEKLEQMARR FDRKASMRET WLLENQRLVA QDNFGYDLPA VEAAKKKHDA IETDIAAYEE
RIQGIVAISN ELESERYHDT KRIDVRKDNI LRLWDYLQEL LKARRTRLDK NLTLQRIFQE
MLYIITWMDG MKARLLSPDF GKHLLEVDDL LQKHALVEAD ITVQAERVHD SNVAALKFAN
GDSYKPCDPQ VIKDRVQHLD LCYQELCALA AQRRARLEQS RRLWNFFWEM AELESWIKEK
EHIFSSLDYG KDLTSVLVLQ SKHSAFENEL GARRAHLQEI MDEGDKMIQS RHFGAPQVGD
CMEDVRRQWQ QLEELAAFRR QNLQDTQRFF QLQGDAEDLK AGLLDAKRQM TSDDMGHDEY
TTQRLLKRHR DLRNDVAKNG ATIDALTKQA AMLPEELRNT PDIQRRLKDI RDMYMELMSL
CDLRQKKLDD AMALYTIFSE TDSCELWMGQ KETWLVGLDV PENLEDLEVV QNRLSILASD
MANVQTRVDD VNKAVKQLED SRHPCTKEVK ECQLRLNTRW EAFKAMVEDK KRKVDSALSY
HNYGLECDET EAWIRDKTRV IKSTQDLGND LNAVMTIQRK LYGMERDLAA IEDKLNFLRS
EADQLAKDHP DNAADILSRR AELDAAWDNL RATLKDREDS LGEVSKLQTF LQDMDDFQSW
LFKTQKAVAS EDMPETLPQA EQLLNLHDDV YDDMDAHEED YHKVRDTGVA VTQGQLDDPQ
YQELDKRLKG LDRGWDELHK MWDSRKGFLD QGLGFQLFMR DTKQVETILN NQEYTLAHTD
KHDTLDGAEH ALKKHEDFVC TMDANMEKLA STLEGGQRLV DSGNLYSPRV QDKMDSIYDR
YNKNRGKANE VTGILKDNRD LQHFLQNTQD LTLWINEKML TAQDVSYDGD RNLHTKWKKH
QAFMAELASN KDWLNKIDQE GQELMDSKPD FEPIVTVRLA KLHELWDKLE STAEDKACLL
FDANRSELFD QSQADMKKWL AELQKELQGD DEVKDLTNAN ILLKKHQQTE NHVRDRAREL
EDLQEAVQKH GGPAGSREDQ PELEAEQQAI QRDFQQLLTP LAQRRGKLEA AKAVHQFYRD
LADEILWVEE RLPLAMSDEH GSNLQTVQLL LKKNQTLQRE MKGHQPRVNE VLERGRRMAS
AATEEGGPEA ERIGEQVKEL KEVWARLQEE MAKRRDRLNG SNRAQQYYND ADEAEAWIGE
QELYMIADDK AKDEQSAMLM LKRHLIVKQA VDDYSDSIQK LSDRAQKMLN EDHPNGESII
RRQGQVDKQY AGLKDLAEER RRKLDHVYHH FLLSREVEDL EHWIAERDVV ASSQEMGQDL
DHVTILRDKF RDFSRETGMV GQERVDYVNQ TIDELIKAGH TEAAAMADWR DSVNESWADL
LELVDTRAQL LQASHDLLKY FDDGKELVSQ IQEKLNEIPA DLGEDFSKAD TFHRMHAAFE
RDISALGKQV QQFQETAACL HAQYAGDKAT EIQAQEKEVV EAWKALLDAC DGRRKRLEET
ADKFRFFTMV RDLMAWMEST IQQIETQEKP RDVSSVELLM KYHQGIRSEI DQRGPKFSDC
VAHGKALLAR KHKYSAEIKE KLIQLMEKKK EMMTKWDDRW DWLRLLLEVC QFARDASVAE
AWLVAQEPYV ASKDLGQTVN EVEKLLKRHE AFEKSTATWE ERFSALERLT TLELLELRKQ
QQEIQQFVTE EQKPSQMESR REDTGFAEDS SQLYTIEEQT LSASGAVEVE PSLGQLEGTA
GDSTVPMVSE MQDAGLQEAS SLELLDASVS GHTPREREPR AATLPADPLS PKAVLQEGML
GRKHDLEAAG KKASNRSWNN LYCVLKPGQL SVYKDAKSFG HGSNYHGEGP LSLSNAKWEV
LNNYKKKKHV FILRLGDGSE YLFQCKDEEE LGCWTQAMEK AVKPLAQEEV EPSGSAGVRA
RSLPPPSSST TLTTPEPAKD KKDKEKKGFS RFANKK
//
