ID A0A1S3SRJ9_SALSA Unreviewed; 4549 AA.
AC A0A1S3SRJ9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Dynein heavy chain 14, axonemal isoform X2 {ECO:0000313|RefSeq:XP_014066964.1};
GN Name=dnah14 {ECO:0000313|RefSeq:XP_014066964.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014066964.1};
RN [1] {ECO:0000313|RefSeq:XP_014066964.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014066964.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; XP_014066964.1; XM_014211489.1.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000087266; Chromosome ssa09.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 2.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 1502..1640
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1789..1977
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2264..2490
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1887..1912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3170..3232
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1897..1912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4549 AA; 516195 MW; 2EC80A9C23F8D940 CRC64;
MEQTPGSSSG KGSNELPPRI DTLLHRKNVK EKEESYISML LKKNKHVNRS CIKFCKLSGV
GESPPENALS SNVSRSPLHG RNIKKSGCLF QPSKQEPLCL KRGVIEPIKH LCKASMIPDT
WNYKGKRVKD VRFDAKEPDN DCVVSHIIRL REKLGWSTEI PDRRIAKACP QNIQEIPEET
KKDPGEYVYC LMRNRGDLKI QPNPYDLQVV SVQTAKQSCQ YWTVSASCIF KVSVLEDRSG
EIMSVIDWLS ERELFFKIFK LPLFAKFRIW KAFTIWKVTV CHSKTKKAKE ILSKGIFFTD
DIFLRCLVEI KGLFEMASDK TRYGDSDGAI VLTKLDKSTT YSLIGFCEAQ TQQCAVALRQ
LHCLHHKVAS LIRAACLKAA EVQGAERLFL PLSSQSTNRP LYAEVAEWRM LLCRFSHFLN
MIDRMFEEML CVLVRSAVQL LLLFLRESSN TNGVNERRQK TNQGQPQLVN KMLPDFKKEE
PKEEIQAVFE VNVLLTVTPV NQPMTDDVSA KGTATTELHS EVDTKDTEKD KEVSREETPR
RSPSRRVKLT IYPCLDDFTL HIQQVLQGFQ QVIAKQTSFN QDPNLLDLHS PPVFDLKLSV
DEELEKERDQ HLRPWPELEL LLGTDPAFQS DLSDILSTVQ RGMQEVEKHC QRLDKFCDMV
ETAMLTDMDG FLAGEKWSPQ DIKAILAVHT ESIRLMKRIE TETRVNMILV RCHQYQSNCL
LYPEALIFTI HSMLPSIVKK KNLELMEVIR GALKKLDKDI FTVEEFVEHL TFLSRISVQI
PTLERQYQFL IQLYSMAKEY QITISPEELA LYQHLVPSFQ HLKSAVMICE TKRDDNIFKF
SVDLGKHLNQ LRFELVLVKM KVNNPILLCS YTSPKVANEI LQALSEEVAI YSNKAYSYTS
YGELLRNSFS MKKISTVVRM KQCRGSNAAE VEAELSEVDC ALTLRKMLWG MQKEWDKQYS
RWRATTFELL NVDDLQNDVS RFTQTIYMLE KGLPENNIVP ILKQKVMDFK LCLPIIVALR
NPYLRQRHWE DIQSYIGRFF TKEDNFTLGN LLDIKILQQS GSIGDISTTA TNEATLESIL
YKVIDLWRST DFRLITHQSD TSTVKIIVSA DDVMAQLEES QTTIMSIKAS RYAEPIKYLI
DEWERKLNQF SHTLEEWVMC QKRWLYLEPI FSAGGIQRQL PAEAKVFLQV DQSWKEIMRR
TNDRPNALRA ATAPGVLEML QAGNVHMEKI QKCLEDYFES KRTVFARFYF LSNEELLDVL
SQSKNPNAIQ PHLVKCFSNI RHLDIQEHAT IYHVVASIRS AEGETVTLPK NVQIRGPVEQ
WMGNVETAMY NTVKRRLKLG VSEWNPQNFK KWVLSHPGQV VLTVTQIMFT KDCQESFSSE
RQLESMVVVK QQVIHNVEEL ADLVSEPLPC HQQATLEALL TILVHCRDVL SHLLQNRITS
VDDFEWTRQL HYVWYDSTSL CYVVHAQASF IYGYEYLGCS PRLVITPLTD RCWLTLTGAL
SLHLGGAPAG PSGTGKTETV KDLAKALGKF CLVLNCSDSL DYKMMGKLFS GMVQSGSWCC
FDEFNRINVE VLSVIAAQLQ SIKAAMHSHS LRFMFEGRDI RLNASCGFFI TMNPGCKGRV
DLPDNLKSLF RPVSMMVPDF DLIAEIMLFS EGFKSAKSLS RKIVNLYQLA SKQLSQQDHY
DFGMRAIKSV LVLAGQKRRF AALSCGLTPE DEYCVLICAL QNSNLPKLVP EDVPLFKSIM
EDLFPGIVNP KTIHPQLEIA IAKATEMLGL QQWPNQAEKV TQLYSQILAR GGVMLIGPTG
GGKTTARLIL QHALHLLPSL SEVHRRTSVF MQLAPSSEVH VESFTINPKC VSFGELYGQV
DPNTLEWSDG LFASAVRTYA KELFEQDNKT SKDSESRNTS SSDVLSDSTT PLPPSSYQHN
FVVDNWRWII MDGPVDILWV ENLNTALDDN KTLCLVNGER ISLPDGIRFL FEVDTLSQAT
PATISRCAMV YMDPVDLGWK PYVRRWLSQL PRQLSREGRN HIQQLFDNSI TQGLNFVKKH
QKLLNFQIPE MSTVMTVCSI LGALINFMQG NGGLGLNLET LSEEDIGKTS ADNESTGKGE
DNKWFLQKNP EKLKILLGKL FVFSYAWGVG GVLNHVDDYD DSPSATKDKS CHLLNVSHAF
KNLIHKLFEG APCGVSLPAG NRMIFNYFVD LQTGAFVPWD ELVPSTESLI RKGLNTSSGS
ESLQLGGVLA ESNTTDTTSF LRSGPICSND TVRYSFLMSL LLLNKQPVLL TGDSGVGKTI
LIQSILKKLQ EDGGEMVNQG TILGQVFLHN QAKTASLLED VNLLTAVFGG DADKSTGDDS
LSGLLSSMPF GVLRRMRSPS HTSESSGILT CTLQCTARTT TAYIQAHMLQ NLVKKGKNNL
GAPKNKSVLV FVDDLNMPTL DSYGAQPSME LIRQFIELQG VFDAKTLTWK SIQDVTLCAA
CAPPGGGRQN LSPRLLRHFS VLLLPHPSSN TMQHIFQVQL GKFFGIRDFS KEVRKCREAL
VSASIAVYIE MCQRMMPTPA KYHYTFNLRD LSKVVQGLMQ ASDSELNSEE AAAYLFSHET
SRVFHDRLVN EQDRELFFQI LSNELHSYFK VSWPPEELMR EPIAFGDFLD MSIPTASRIY
KHLPDFKKIQ AVLEECHTRH GRKASQFPMV FFREAVEHIT RAARVFRLKG AHMMLIGLDG
TGKEECVTLA CHVSGSHLYR LSVCRNCSYS DFRDDLKRVF RQAGIHRKNT VLLITDSDIV
KESVLEDLNC ILKYGDVPGL FDNDEIDSIT VDLKSTMESS IGENREEMYS YFIEQVHQRL
HIVLALSPAG MRLRQYCWAH PALLSCCNID WYCEWSKDAL LQVASSTYIN SDDFDWLGQV
LQNKVARVCV DIHYSSTQMA AQYLQEMRRP YYIVPSTFIE YIDTFTKMCR SEGSKLHNVR
DRFSNGLSIL SEATSLVTVM QDELLALGPQ IEEKSKEIEI LMGKLKEDSQ AVEQVRAITK
MEEDMMVQET RIVHEYAEDA MADLNKVLPL LEKAVSALDA LEKSDISEIR VYTKPPELVL
TVMHAVCILL QQKPDWTTAK QLLGDPGFLK RLVSLDKDSL PEKVFLKLRR YSKCPDFNPA
KVGMVSIACR SMCLWVLALE HYHDVYKIIE PKQNKVNVAQ AALVKSKSNL MKKQKRLSKI
EEHQKALEDH YNASVSERQE LGRRKERTTN RVQRAASLIS ALSNEKDRWE KAVCDLDNKL
QHIVGDVMVS SAFITYCGPL TADFRKAMVK KWLDFCHNME IPISPQYTFT SAMTEKNQVR
HWQNTGLPPD QNSTENALIV KNGPHWPLLI DPQGQAIRWI SSMEGVRLRK ILASDPNYMK
TVERAIRMGD AVLIQDVLEN IDPCLQPILI KNLTIREGQS FIKIGDTEIE YNPNFRLYLA
TCLPNPHFLP AVCVLVKLIN FSVEYECLQE QLLSSAVSLH QAELELHHNQ LLHTITADLF
SLHELENRSL LLLQDTQGHI LDDQDLVDNL NKSKVTSNEI SVRVETAKDK EKEIDEVRKK
YLPIANRGAD LYFVLADLTQ INYMYQFSLD WFNDMYVKAL QVATEGQEWP TLDVSMPVTG
TLRPAGAKSL RRAVVVPGTC APNMGDFNLR LLKMMNAITE SIYKEVSLAL FVDHQVVFSF
LMCCNIMKTN KHNMIVGSTE FLPAEEWKIF LHSAVLASMM DSKRAEQEEG EFLGERPDYP
WLTDSMWAQC QYLCAHLPCF ATLYKSIQTN RVQWELFQQA RNLYEFLSEP YAGHAASDTE
GESSQSAAAS KDRHLTKCVH IFPWESLSGF QKIILVKILR PECLNTAVKA FVIEKMGSKY
LEVGRISLRE VYERCSANVP IVFLLSPGMD PASLVVRLAQ ELRGSSLHLD MVSLGQGQGP
RAEELIYKAQ VLKGRWVFLQ NCHLAASFMP RLQTVVNSLK WKGSDLDPHF RLWLSSKPDP
VFPASILQRA VKIAVEPPRG LKEKLLHTFS PSGEVTERSF CKMDCSPAWK TLLFSLCFFN
AIVQERKKYG PLGWNIPYTF TSSDLEVSML NQESLLLAAE GSELPWAALR YLTGEVIYGG
RVTDPWDRRC LLTILHRCYT PSVLQDGHSF CQAQGYPPFP KDASWPQCRA YIENMPDQDL
AEVFGIDSSA EMVILQNQTQ QLLHTIVNLQ PRLSDSSLLV RDRQCQDSVV LRMAMKILKK
LPETVEFDRV TEKTLFLRDI IAKVNFAESS SSDQGERRTA SASSALLVIL RQEIDRFNYL
LCVVRSSLLS FSASIRGEVL MSEALAEVHT ALLTMIVPSD WKHCSYESCM ALGSWIQDLE
QRVWFFRAWA DNIKINLIEK IPMISGEVYS LNRPPKTDLQ QSLKNRKPRS YWLSGFFFPQ
GFLTAVLQNS ARQKNVPVDS LSFTHHVQPV DESSSNWSKV ADKTKLLFEG PAPPDEGVLV
YGLYLDGASW DPVSHTLQEL QHNIKHCPVP EIHFLPCRVS EDAVAVPTTE SPGDLQFYDC
PLYRTFKRAG FLSSSGISTN FITVVSLPTS ECPTHWVFRG TALLCQPNE
//
