ID   A0A1S3SV36_SALSA        Unreviewed;       688 AA.
AC   A0A1S3SV36;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=X-linked interleukin-1 receptor accessory protein-like 2 {ECO:0000313|RefSeq:XP_014068205.1};
GN   Name=LOC106611984 {ECO:0000313|RefSeq:XP_014068205.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014068205.1};
RN   [1] {ECO:0000313|RefSeq:XP_014068205.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014068205.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC       {ECO:0000256|ARBA:ARBA00009752}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_014068205.1; XM_014212730.1.
DR   AlphaFoldDB; A0A1S3SV36; -.
DR   GeneID; 106611984; -.
DR   KEGG; sasa:106611984; -.
DR   OrthoDB; 3994459at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa09.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR013151; Immunoglobulin.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11890:SF10; X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2; 1.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Receptor {ECO:0000313|RefSeq:XP_014068205.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..688
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010222914"
FT   TRANSMEM        356..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          3..132
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          160..230
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          240..347
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          399..557
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   688 AA;  79401 MW;  910C0868EF2AF661 CRC64;
     MKPSVLMFLL ISSAACINLK YISKRNSVDG CIDWSVDLKR YRVLAGEPVR VKCALFYSYI
     RTNYSMTQSA KLRLIWYKNK GDSEEPIIFS GHRLSKEDDS IWFRSAELED NGFYTCVLRN
     STYCMKVSMS LAVEENDEGL CFNSKIRHLE KAEITKSKMI NCPDIEDYLA PYKQPQMTWY
     KECEKRTWRS SIMVNITNIW FPEVQEDDGG NYTCELKYGS RVVRRTTELK VTALLTTRPP
     KVLFPTERQA SVIDVQPGMP LSLDCKAFFG YSGESRHIIY WMKGEKFVEE LAGHIKESEV
     RVLKEHLGEK EVELSLTFDA VEETDLGNYT CYVENHIGRR SGSAILQKRD MYRLELAGGL
     GAILLLLGVF TAIYKCYNVE IMLCYRRHFG SDETEDDNKE YDAYLSYTRV ELESMDRGSS
     EEEQFALEIL PDVLEKHYGY KLFIPDRDLI PSSHSIYIED LARSVEQSRR LIIVLTPEFV
     AKRGWSIFQL ETRLHSMLVT GEIKVIMIEC ANLKSVINYQ EVEALKHTIK VLSIIKWRGP
     KSNELKSMFW KQVIYEMPVK RKEMLSRRQV LDSREQGLFG DLQTVSTIAM TTTSASMVPA
     HHAEIPDFNQ TSHPQMRHYC TRSYEYKMPA SPVQIATLSN RHIYCNIPMT LLNGQVTQNN
     TMGKSKQEIH LNSTFVPLSG GEHTSDIW
//