ID A0A1S3SVH7_SALSA Unreviewed; 114 AA.
AC A0A1S3SVH7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Insulin {ECO:0000256|RuleBase:RU000406};
GN Name=LOC106612054 {ECO:0000313|RefSeq:XP_014068347.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014068347.1};
RN [1] {ECO:0000313|RefSeq:XP_014068347.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014068347.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC cell permeability to monosaccharides, amino acids and fatty acids. It
CC accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC synthesis in liver. {ECO:0000256|ARBA:ARBA00002985,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR RefSeq; XP_014068347.1; XM_014212872.1.
DR AlphaFoldDB; A0A1S3SVH7; -.
DR STRING; 8030.ENSSSAP00000034613; -.
DR PaxDb; 8030-ENSSSAP00000034613; -.
DR Ensembl; ENSSSAT00000060225; ENSSSAP00000034613; ENSSSAG00000041797.
DR GeneID; 106612054; -.
DR KEGG; sasa:106612054; -.
DR OMA; PNRAHKR; -.
DR OrthoDB; 4213741at2759; -.
DR Proteomes; UP000087266; Chromosome ssa09.
DR Bgee; ENSSSAG00000041797; Expressed in camera-type eye and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04367; IlGF_insulin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR004825; Insulin.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR11454:SF9; INSULIN; 1.
DR PANTHER; PTHR11454; INSULIN/INSULIN GROWTH FACTOR; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00277; INSULIN.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW ECO:0000256|RuleBase:RU000406};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526,
KW ECO:0000256|RuleBase:RU000406};
KW Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU000406};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..114
FT /note="Insulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010270216"
FT DOMAIN 28..113
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 114 AA; 12906 MW; 102FDC0FC9E5ADEC CRC64;
MAVVVWALSV LLLLVLSSPG VCSAPSAQHL CGSHLVDALY LVCGEQGFFY NPNRTPRDLL
LQHLIGFLSK SRQGWRVKQE RPWKDHEDQK VKRGIVEQCC HKPCSFSHLQ SYCD
//
