ID A0A1S3T2V4_SALSA Unreviewed; 384 AA.
AC A0A1S3T2V4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Transforming growth factor beta {ECO:0000256|PIRNR:PIRNR001787};
GN Name=LOC106613337 {ECO:0000313|RefSeq:XP_014070920.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014070920.1};
RN [1] {ECO:0000313|RefSeq:XP_014070920.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014070920.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transforming growth factor beta-1 proprotein: Precursor of
CC the Latency-associated peptide (LAP) and Transforming growth factor
CC beta-1 (TGF-beta-1) chains, which constitute the regulatory and active
CC subunit of TGF-beta-1, respectively. {ECO:0000256|ARBA:ARBA00002007}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR001787}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR001787,
CC ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_014070920.1; XM_014215445.1.
DR AlphaFoldDB; A0A1S3T2V4; -.
DR STRING; 8030.ENSSSAP00000053777; -.
DR PaxDb; 8030-ENSSSAP00000053777; -.
DR GeneID; 106613337; -.
DR KEGG; sasa:106613337; -.
DR CTD; 359834; -.
DR OrthoDB; 5390486at2759; -.
DR Proteomes; UP000087266; Chromosome ssa09.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-UniRule.
DR CDD; cd19384; TGF_beta_TGFB1; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR016319; TGF-beta.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR003939; TGFb1.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF125; TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF001787; TGF-beta; 1.
DR PRINTS; PR01423; TGFBETA.
DR PRINTS; PR01424; TGFBETA1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001787-1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR001787};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246, ECO:0000256|PIRNR:PIRNR001787};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001787};
KW Signal {ECO:0000256|PIRNR:PIRNR001787}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT CHAIN 18..384
FT /note="Transforming growth factor beta"
FT /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT /id="PRO_5016196472"
FT DOMAIN 269..384
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT DISULFID 287..350
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 316..381
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 320..383
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT DISULFID 349
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
SQ SEQUENCE 384 AA; 43904 MW; 56558630A8CBDA4F CRC64;
MRLVCLTITC LAALCLAGSV NSMSTCKTLD LELVKKKRIE AIRGQILSKL RMAKEPEEGQ
TGVEKDIPVA LLSLYNSTVE LSEEQKLQPQ PTTHTLEEEE EYFAKEVHKF TMKQDKNVTK
HQMLFNLKEM RSSIGDYHLL SSAELRLLIK NSNIPSGSEQ RLELYKGLHD SMRYLGSRFI
TNKWSDRWLS FDVTETLKEW LKGTEEEQGF ELKLYCECGK SEEPFLFTIS GLDSGVRGDV
AGLAKNMRKP HILAMSIPQN YSSQLTSSRK KRATTTDDTC TDKTENCCVR KLYIDFRKDL
GWKWIHKPKG YHANYCMGSC TYIWNAENKY SQILALYKHH NPGASAQPCC VPQVLDPLPI
LYYVGRQHKV EQLSNMIVES CKCS
//
