ID A0A1S3T4L4_SALSA Unreviewed; 1163 AA.
AC A0A1S3T4L4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=LOC106613616 {ECO:0000313|RefSeq:XP_014071536.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014071536.1};
RN [1] {ECO:0000313|RefSeq:XP_014071536.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014071536.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR RefSeq; XP_014071536.1; XM_014216061.1.
DR AlphaFoldDB; A0A1S3T4L4; -.
DR STRING; 8030.ENSSSAP00000049363; -.
DR PaxDb; 8030-ENSSSAP00000049363; -.
DR GeneID; 106613616; -.
DR KEGG; sasa:106613616; -.
DR CTD; 100333101; -.
DR OMA; NQATRVC; -.
DR OrthoDB; 1034721at2759; -.
DR Proteomes; UP000087266; Chromosome ssa10.
DR Bgee; ENSSSAG00000049563; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13720; PBP2_iGluR_NMDA_Nr3; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF364; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 620..642
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 654..673
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 693..714
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 879..901
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 511..855
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 511..567
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 426..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 128613 MW; B9D701D6DD6AFF88 CRC64;
MNLIFSRFLA YFYFGFQVIL QFFIDPCQLH PQPCHILAQI GHTVRLGALL PTRQPARVQA
ALNRALTGLV QTGDNFLPYN LSLEVVPREP ANGDPESLFR CVCQAIVVQG VSAVLAFPQT
QEEIVQVEFM ASFLEIPFIS IIEHGEPLKT QNRFHLQMVT QIPPSGLSEL LLTILQRSGW
QEGMAVLCQG WEEAGLLELL ELQSRLGWGA TRWHLRALLN LTRAGPTESE IQDFLSEHFR
GQGPSQILPP AAVLLFGADP ECAAAVLRSA QDLGLTLPTV HWVLGYPLSP DTLHSIGLPL
GLLAYGEVER KPLDFYIRDA LQLVGQAVAA ATVVRPDLAL IQNMVNCYDK PNKHEVPSSG
QYLARFLSNT SFSGLTGPVS VQRNLSRVLT SQRFHIWSLR RDAVGQPTWV TVGSWEGGRL
KVEDQSLWQG PNGKGHDRGE GQRSGGRWQP GMPVADSRVR VVTLVEHPFV FTREVDEDGN
CPAGQYCLDA GTNSSDMLES YFSERASGNS TFLPTDFSKC CYGYCIDLLE KLAEDLRFEY
DLYIVGDGKY GASKSGRWTG LVGDLLNGVA DMAVTSFSIN SVRSRVIDFT SPFFSTSLGI
LVRSKDTAAP IGAFMWPLHW SMWVGIFVAL HITALFLTLY EWKSPFGMTP HGRNRLRVFS
YSSALNLCYA ILFGRTVSSK TPKCWTGRFL MNLWAIFCLL VLSSYTANLA AVMVGEKTFE
ELSGIHDAKL HHPSHGFRFG TVRESSAEEY MKKSFPEMHE YMRRYNEPTT PDGVSTLKVD
PPQLDAFIMD KALLDYEVSI DADCKLLTVG KPFAIEGYGI GLPQNSPLTN NVSEFISRYK
SDGYMDMLHD KWYKVVPCGK RVFAVTETLQ MGIRHFSGLF VLLCVGVATS LLTLAGEHAF
YHMVLPRIRR RQKYKYWLHT SQKIHRALNQ TYEDVKKKQD TNTEKSSCCL QKNQHPQPPP
DPLLSKASAK WNNENSRDSS AAAAKDNKRV HFNLETLNSR RLLARAVTKS EGGRGGEGIP
GANQATRVCA NGGFGTSFAN LVLSLPSSSS SSIPSSSSLG VPPRPGELQE LQEKIDLIRD
QLRTALARRA ELQTSLAKEK AACSAPIVSG TPPVVLAAAS LPTSTKTTSS LPSTRCATTM
TDPVLKALPT VRTAPAKHTN EKR
//