ID A0A1S3T6D9_SALSA Unreviewed; 2508 AA.
AC A0A1S3T6D9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Probable voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 {ECO:0000313|RefSeq:XP_014072155.1};
GN Name=LOC106613910 {ECO:0000313|RefSeq:XP_014072155.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014072155.1};
RN [1] {ECO:0000313|RefSeq:XP_014072155.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014072155.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR RefSeq; XP_014072155.1; XM_014216680.1.
DR GeneID; 106613910; -.
DR KEGG; sasa:106613910; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000087266; Chromosome ssa10.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF5; VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1346..1365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1418..1437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1483..1505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1595..1620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1676..1695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1707..1729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1735..1753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1797..1815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1890..1913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2050..2084
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 165..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2272..2353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2365..2399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1087
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2272..2312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2313..2341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2375..2396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 472
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 833
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1566
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2508 AA; 283383 MW; 7E0488E1B215F160 CRC64;
MLELGSCSVS AQTLADHSAL GVPHLARGSY GSSNPRHYVL HPESENWRKH RLGLAEGSHS
CSLLEPQSLS DSLLSHTASV NTLYLPHNAH APHGLSLDVG SSYDRAGEAL VMDPDRPVSP
IVIKRRRGGL IEQRDIVKAH QAHKIQSTPQ ALRKEWEMAR FGDDVPGLLD SGDGDSDRNR
TREGPALSTG GGVSPAFKQT KAQRARTMAL YNPIPVRQNC FTVNRSLFIF GEDNIVRKYA
KKVIEWPPFE YMILATIIAN CIVLALEQHL PGEDKTPMSK RLEKTEPYFI GMFCFEAGIK
VVALGFVFHK GSYLRNGWNV MDFIVVLSGI LATAGAHMNI PVDLRTLRAV RVLRPLKLVS
GIPSLQIVLK SIMKAMVPLL QIGLLLFFAI LMFAIIGLEF YSGKLHNTCL PMPNILENET
VDKSESEFPC GVRKCPDKYA CRDTWIGPND GITQFDNILF AVLTVFQCIT MEGWTTVLYN
TNDALGPTWN CMYFIPLIII GSFFVLNLVL GVLSGEFAKE RERVENRRAF MKLRRQQQIE
RELNGYRAWI NRAEEVMLAE ENKNLGPSAL DAPKRLSEWN TGGNHVLKRA TIKRRGVDAV
HRGPEDEQYG DISSVGIPMT RASIRSAKRG PTAYFKRKER LLRISIRRMV KTHTFYWTVL
GLVALNTLCV AIVHHNQPRW LSVFLYYAEF LFLGLFLTEM CLKMYSLGPR LYFHSAFNRF
DCGVIVGSIF EVMWGFFRPD MSFGISVLRA LRLLRIFKIT KYWASLRNLV VSLMNSMKSI
ISLIFLLFLF ILVFALLGMQ LFGGRFIFED YTPTNFDTFP AAIMTVFQIL TGEDWNEVMY
NGIRSQGGVK SGMWSSIYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK DEEDEEAAFN
QKHALQKAKE VGAMSSLMSS HRRRRPYLYR KRAIHRSRPA YSLEEAESLA EGPPCPPLNS
SNSFMSRGER RRRMTMSVWE QRTSQLRRHR QMSSREILFS SPSEEQEAPP GCPHHLKATG
TPTGSLKLAD PTADPTASLS QPPKPMDLTL EKPPLSMGVL EPPLSVPLAE PPIPIDSPLP
DPPTSTVVSI PEPTESEPCP EGQVDVTDHC HPGLNGRRSP RLNGERRQRA VRKFRPPAGD
TLTPDMAGMR LRRPRGTGHH EAQVGARGLD SPQGEGSSRS VSRERKTPEE QQDKERRACN
TGETSQPSET REAEHRQGDP NQAGGPQLQN GEEGPQSEPP PLQSFQVAVP ELPEGQTGDS
DTGNNATTLN QDKSPLSSSI YIEVTNVQSS LELTPSTGNS KDMEVSKPEK EEEQLTSPAN
IVTPDSMFIF KPGNPIRRAC HYVVNLRYFE TCILLVIAAS SIALAAEDPV SATSNWNKVL
RYFDYVFTGV FTFEMIIKMI DQGLILHDGS YFRDLWNILD FIVVVGALVA FALTNVLGNN
KGRDIKTIKS LRVLRVLRPL KTIKRLPKLK AVFDCVVTSL KNVFNILIVY KLFMFIFAVI
AVQLFKGKFF YCTDGSKDTE KDCQGFYIDY EKDKKEVKRR DWRRHDFHYD NIVWALLTLF
TVSTGEGWPQ VLQHSVDVTE EDRGPSRGNR MEMSIFYVIY FVVFPFFFVN IFVALIIITF
QEQGDKMMEE CSLEKNERAC IDFAIGAKPL TRYMPQNRQT FQYRLWHFVV SPSFEYTVLA
MIALNTIVLM MKYYSAPPAY EAVLKHLNTA FTVLFSVECV LKIMAFGFLN YFRDTWNIFD
FITVLGSITE IVVDLQSIET FNMGFLKLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY
VCLLIAMLFF IYAIIGMQVF GNIRLDEETH INQHNNFKTF FGALMLLFRS ATGESWQEIM
LSCLGGQKCE PDPLALTSDH EERCGTEFAY FYFVSFIFFS SFLMLNLFVA VIMDNFEYLT
RDSSILGPHH LDEFVRIWGE YDRAACGRIH YTDMYEMLTL MSPPLGLGKK CPSKVAYKRL
VLMNMPVDEE MSVHFTSTLM ALIRTALEVK IARGGEDRGQ MDSDLQKEIS VIWSHLSQKT
LDLLVPIHKA SHMTIGKIYA AMMIMDYYKQ SKAKKLRQQL EEQKHAPMFQ RMDASSLPQE
ILCSAKAFPF LPHSPGSALT RGGFVALSPI SPQEMFMQPM SQDLEDKEED YQNYHHHHLL
HHQLHHQLHT LVPERKEFNR NLCPTNRQDA PLRVPGRAVS IRASSMPRLA VDTQVGTDSS
KSMKRSFSTI GDQCMNGLWQ EEYSLKRVSP DRLNRPRQRS IRGIRCNLRE PVDHERGRSK
ERRHLLSPDV SRCNSEERSQ DPSQERKQSR SPSEGCTHAL HRQGNTSGSP DLSSTPRGRR
QLPQTPLRPR PHISYSPLVC RAHLSPPAAS EGRARTQEAP RETEEPSLRE EGERLAPESG
AGVGVVIGVG GPGLGVSHLH PSPHRYISEP YLTLHEALHS PDSSGLDETL TFEAAIATSL
GRANTISSAP QLRHNWQVPN GHFHKRLGQA SSVVACELLS DTDEDDHC
//
