ID A0A1S3TJ33_VIGRR Unreviewed; 3769 AA.
AC A0A1S3TJ33;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC106756038 {ECO:0000313|RefSeq:XP_014493761.1};
OS Vigna radiata var. radiata (Mung bean) (Phaseolus aureus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Vigna.
OX NCBI_TaxID=3916 {ECO:0000313|Proteomes:UP000087766, ECO:0000313|RefSeq:XP_014493761.1};
RN [1] {ECO:0000313|RefSeq:XP_014493761.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_014493761.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR RefSeq; XP_014493761.1; XM_014638275.2.
DR STRING; 3916.A0A1S3TJ33; -.
DR GeneID; 106756038; -.
DR KEGG; vra:106756038; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000087766; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05170; PIKKc_SMG1; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR031559; SMG1.
DR InterPro; IPR039414; SMG1_PIKKc.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_014493761.1};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087766};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1143..1767
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1980..2321
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3737..3769
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3574..3604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3616..3638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3769 AA; 421469 MW; 4CA762E0EBF1824C CRC64;
MQGIHQHQQH QHLAALVSAA LPKDDSDEDP SPRLAAIHSL HRAILHPHNS LLLSHSATFL
AQAFSQLLSD KCYEVRQAAV TAYGALCAVA ASIPVASNGR QNLLMLVDRF IGWALPSLST
AVAVDGTKEL ALEGLREFLN VGGTDRYALP ILKACQVLLE DERTSLALLH RLIGVITLIS
LKFVRCFQPH FPDIVDLLLG WALMPDLAQS DRRVILDSFL QFQKHWVGSL PMSLRLLTKF
LGDMEVLLHD GTPGTPQQFR RLLALLSCFS TILQSTASGL LEMNLLEQIC EPLSALLPRL
LRCLSMIGQK FGWSEWIEDS WKCLTLLAEI LQERFSSFYP LAVDILFQSL EFGVTVQRPG
LKKMSSFQVH GVLKTNLQLL SLQKLGLLPL SVKKLLKFDA SVSQLRLHPN HLVTGSSAAT
YVFLLQHANK EVVDEAVISL IEELELLKSL IGNNNGHSYE FNRIIDTKTF SEAELLALIK
FDLKVLLACV CMGEDNSLIK QKDIASLYLR RLEKLESFIT KQMNPFELPI QNFMELQITV
VKTLERLNSV EFLIKCSVRE ENCEKTLVEF PTEKEDRDDQ FSNERLAVIT EHLEKYSKLV
VKAFHVSSPL AIKLIVLDWG QKFCESVMAV NKISSISGFS YEACEYASVI MNLVFSLLGG
TFEREQEVRS HVAITLEMFM QAKLLHPVCF YPLAEVILEK LGDPTIEIRD AYVRLLAHIL
PTTIYTCGLY DYGRFRSVDP VLGNNSKLHW KQLFALKQLP LQLHSQHLVS ILSYISQRWK
VPLSSWIQRL IHSCQSSKDA ILSLPEETGI FGANSPWLDI RVDEDILEKI CSVNNLAGAW
WAVQEAARYC IATRLRTNLG GPTQTFAALE RMLLDIAHLL QLDNEQSDGN LSMIGSSGAH
LLPMRLLLDF VEALKKNVYN AYEGSVILPP ATRQSTLFFR ANKKVCEDWF SRICEPMMNA
GLAVHCNDAV IQYCTLRLQE LKNLSVSTLK EKSRTQVTDN LHNIRGRYKG DVLKVLRDVS
LALCKSSDPE SLIGLEKWVS ITFSLLGDEN QSFSEGGTVG PLSWISGLIY QARGEYENAA
AHFTHLLQTE ESLSSLGSDG IQFVIARIIE SYTAVSDWRS LETWLLELQQ LRAKHTGRSY
SGALTIAGNE VNAIHALARF DEGDYQAAWS SLDLTPKSNN ELTLDPKIAL QRSEQMLLQS
LLFQKEEKSD KVLHDLQKAR SMLEEPLSVL PLDGLAEATP LAIQLHCIFL VEDNCKLKTN
HEKAKQLPSI LNSLESLPSS ISKIRQDCNP WLKVLRVYKT ISPSSPVTLK FCINLHNLAR
KQNNLLLANR LNNYIKDHVF ACPEERHRNL LVLNLQYESI LLQYAENKFE DAFTNLWSFL
HPCMVSPKPS IISDVKERIL KAKACLKLSD WLRRDYSDWS PEGVVLKMAA DFDLAESSPC
GKDGSKENLS CKSNLGSIIE EIVGTTTKLS SRICPTMGKS WISYASWCFK QARDSLHVHS
ETILHSCSFS SMLVPEILPD RFKLTEDEVR RIKSLVLCLF QDNIDMKGFT DEQEERSSWL
DSAELSISES PLQKLVWNIV NVIETAAGAS GAENSGGECL SDMVSSQLRI CLLSTNFGLG
ESDITSALDN FVDIWWSLRR RRVSLFGHAA HGYIQYLSYS SSRICHSQVP GSEYETLKQK
AGSYTLKATL YILHILLNYG VELKDTLESA LLVVPLLPWQ EVTPQLFARI SSHPEQVIRK
QLEGLLTMLA KQSPYSIVYP TLVDVNAYEE KPSEELHHVL GCLRELYPRL VQDVQLMINE
LGNVTVLWEE LWLSTLQDLH TDVMRRINLL KEEAARIAEN VTLSQNEKNK INSARYSAMM
APIVVALERR LASTSRKPET PHEAWFQEEY KDQLKSALVS FKIPPVSSAA IGDVWRPFDS
IAASLASYQR KSSVSLGEVA PHLSLLSSSD VPMPGLERQM QVPDSDKATD HQGVVTIASF
HEQVTILPTK TKPKKLGILG SDGQKYTYLL KGREDLRLDA RIMQLLQAIN GFLHSSSSAC
SNSLTIRYYS VTPISGRAGL IQWAGNVVSI YSVFKSWQTR VQLAQFLALG SANTKSSAPP
PVPRPSDMFY GKIIPALKEK GIKRVISRRD WPHEVKCKVL LDLMKEVPRH LLYQELWCAS
EGYKAFSSKL KRYTGSVAAM SMVGHVLGLG DRHLDNILID FCNGDIVHID YNVCFDKGQR
LKIPEIVPFR LTQIIEAALG LTGIEGSFRS NCETVIGVLR KNKDVLLMLL EVFVWDPLVE
WTRGDFHDEA AIGGEERKGM ELAVSLSLFA SRVQEIRVPL QEHHDQLLTS LPAVESALER
FGDVLNKYEL TSSLYCRADQ ERSTLILHET SAKSIVAEAT SNSEKIRASF EIQAREFAQA
KAMVAEKAQE AMTWAEQHGR ILDALRCNLI PEINASFKLN NMETVISLTS AVIVAGVPLT
VVPEPTQAQC HDIDREVSQF IAELGDGLTS ATASLQAYSL ALQRILPLNY LSTSAVHNWA
QVLQLSINAL SSDMLSLARR QASELIAKLH VDNSDSIKFS HDDLCFRVEK YAVEIEKIEK
ECAEIESSIC SESESKTKDR LLYVFMKFMQ SIGLLKKEVG NSSVQSKYDS EMNNARPLGE
LEEEREKVFS ILNIAVSSLY SEVKHTILNI YNDTSGGRNQ YNMLQNDSGT IFAEFEEQVE
KCNLVTEFVH DLCQFIGKDI PSVDINQVRL KIFSESNWVS IFSNILISCK GLISQMTEVV
LPDVIRAAVS LNSEVMDAFG LISQVRGSIE TALEQLMEVE MERVSLIELE QNYFVKVGLI
TEQQLALEEA AVKGRDHLSW EEAEELASQE EACRAQLDQL HQTWNQRDIR TSSLTKRETD
IKNALVSVNC QFQSLVGVEE ERELHILRSK ALLASLVKPF LELESIDILL SSTDGSVAMP
TSKFHTLTDL INSGNSISEY VWKVGGLLDN HSFFIWKIGV IDSFLDACIH DIASSVEQNL
GFDQSLNFMK KKLEIQLQKH IGHYLKERVA PSLLACLDKE NEHLKQLTES SKELALDQGK
KDGAVKKVIL MLEEYCNAHE TARAAKSAAS IMKNQVSELK EALRKTALEV VQMEWMHDVS
LNPSYNRRIR FEKYLDTDDS LYTIILNLNR SKLLDNVQSA VSKITTSMDC LQSCERNSLI
AEGQLERAMA WACGNSSNSG NTSTTNSGIP PEFHEHIKNR RQILWESREK ASDIVKLCVS
VLEFEASRDG YLFIPDQPYP FRSSVDAKTW QQVYLNALTR LDATFHSYSR TEQEWKLAQC
TVEAASNGLY TASNELSIAS LKAKSASGDL QNTVLSMRDC AYEASVTLSA FARISRIQTA
LTSESGSMLE EVLAITEDIH DVYNLGKEAA GIHLSLMEGL SKANAILFPL ESVLSKDVAA
MADAIDRESE TKKEISHIHG QAIYQSYCVR IREACQNFKP LVPSLMLAVK GLYSLLTRLA
RTANVHAGNL HKALEGIGES QEVKSVTTTL SRSDGGGDDA VEFDGKEGVG LYRSEDDKTD
DFIGFSRLSL EDKGWISPPD SIYCTGSGSD MTATEVSLPD SLNDSAGNKE LLSQGSSSRN
PTGHMHTAVF SQTEVEEISP FGLSQSSPAE TDLNGSGSVK SINEATEHSE AIVVLGDKTA
AIPANSQNPT NKNIDKFDSA DEPLSAKEIK NATEHRDARD LNVNANTRVG RGKNAYALSV
LRRVEMKIDG RDISESREID ITEQVDYLLK QATSVDNLCN MYEGWTAWI
//
