ID A0A1S3V5Y0_VIGRR Unreviewed; 736 AA.
AC A0A1S3V5Y0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial isoform X2 {ECO:0000313|RefSeq:XP_014513758.1};
GN Name=LOC106772100 {ECO:0000313|RefSeq:XP_014513758.1};
OS Vigna radiata var. radiata (Mung bean) (Phaseolus aureus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Vigna.
OX NCBI_TaxID=3916 {ECO:0000313|Proteomes:UP000087766, ECO:0000313|RefSeq:XP_014513758.1};
RN [1] {ECO:0000313|RefSeq:XP_014513758.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_014513758.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR RefSeq; XP_014513758.1; XM_014658272.2.
DR AlphaFoldDB; A0A1S3V5Y0; -.
DR GeneID; 106772100; -.
DR OrthoDB; 1129179at2759; -.
DR Proteomes; UP000087766; Chromosome 8.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR045774; MCCA_BT_dom.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR Pfam; PF19331; MCCA_BT; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000087766}.
FT DOMAIN 37..483
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 156..354
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 658..734
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 736 AA; 81007 MW; 32A4E7D2A6CE0C22 CRC64;
MASLALIRRK IIITRTTLSH WHVCTRAFSN ADSNNNRIEK ILVANRGEIA CRIMRTARRL
GIQTVAVYSD ADRDSLHVAS ADEAIRIGPP PARLSYLNGT TIVDAAIRSG AQAIHPGYGF
LSESAVFAKL CEDSGLTFIG PPASAIRDMG DKSASKRIMG AAGVPLVPGY HGDDQDIERM
KLEADKIGYP VLIKPTHGGG GKGMRIVHSP EEFVESFLAA QREAAASFGV NTILLEKYIT
RPRHIEVQIF GDKHGNVLHL NERDCSVQRR HQKIIEEAPA PNISADFRAH LGQAAVSAAK
AVNYYSAGTV EFIVDTVSDE FYFMEMNTRL QVEHPVTEMI VGQDLVEWQI LVANGEALPL
NQSQVPISGH AFEARIYAEN VQKGFLPATG VLHHYHVPVS SEVRVETGVK QGDTVSMHYD
PMIAKLVVWG DNRASALVKL KDSLSKFQVA GLPTNVSFIL KLANHGAFAN GNVETHFIDN
YKEDLFGDGN NSVSDKEAYE AARHNASLVA ACLIEKEHFV SSRNPPGGGS LLPIWYSSPP
FRVHHQAKRK MELEWENEYD SGSSKTMKLT ITCQPAGRYL IETEENGSPV LDVKASYVKD
RHFRVEAGGV INDVNVAVYS KDQTRHIHIW QGSHHHYFRE KLGLDLSEDG ELQHKPKVET
SANPRGTVVA PMAGLVVKVL VENKTRVEEG QPVLVLEAMK MEHVVKAPSS GYVHELQVTV
GEQVSDGSVL FRVKDQ
//
