ID A0A1S3VH73_VIGRR Unreviewed; 183 AA.
AC A0A1S3VH73;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=4a-hydroxytetrahydrobiopterin dehydratase {ECO:0000256|ARBA:ARBA00013252};
DE EC=4.2.1.96 {ECO:0000256|ARBA:ARBA00013252};
GN Name=LOC106775157 {ECO:0000313|RefSeq:XP_014517713.1};
OS Vigna radiata var. radiata (Mung bean) (Phaseolus aureus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Vigna.
OX NCBI_TaxID=3916 {ECO:0000313|Proteomes:UP000087766, ECO:0000313|RefSeq:XP_014517713.1};
RN [1] {ECO:0000313|RefSeq:XP_014517713.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_014517713.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC Evidence={ECO:0000256|ARBA:ARBA00001554};
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000256|ARBA:ARBA00006472}.
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DR RefSeq; XP_014517713.1; XM_014662227.2.
DR AlphaFoldDB; A0A1S3VH73; -.
DR STRING; 3916.A0A1S3VH73; -.
DR GeneID; 106775157; -.
DR KEGG; vra:106775157; -.
DR OrthoDB; 394162at2759; -.
DR Proteomes; UP000087766; Chromosome 10.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR CDD; cd00913; PCD_DCoH_subfamily_a; 1.
DR Gene3D; 3.30.1360.20; Transcriptional coactivator/pterin dehydratase; 1.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR PANTHER; PTHR12599; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE; 1.
DR PANTHER; PTHR12599:SF17; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR SUPFAM; SSF55248; PCD-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000087766};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..183
FT /note="4a-hydroxytetrahydrobiopterin dehydratase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010237524"
SQ SEQUENCE 183 AA; 20583 MW; 18822EDE68952659 CRC64;
MNHLLLLFRH PLLPLSVAAA KLSLQPFSQT YYSYTRRGMN SEIFHGASSP LTTATFCITN
KDLSAKKCVP CNTKDLQPMT QDEARTLLPQ VADWDLVNED GVLKLRRSWK VKTFTKGLEF
FRIIGDLAEA EGHHPDLHLV GWNNVTIEIW THSVGGLTQN DFILAAKMNG LNLHGLLRRK
ASD
//
