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Database: UniProt
Entry: A0A1S3W2A0_ERIEU
LinkDB: A0A1S3W2A0_ERIEU
Original site: A0A1S3W2A0_ERIEU 
ID   A0A1S3W2A0_ERIEU        Unreviewed;      1150 AA.
AC   A0A1S3W2A0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   Name=DHX37 {ECO:0000313|RefSeq:XP_016040422.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016040422.1};
RN   [1] {ECO:0000313|RefSeq:XP_016040422.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000256|ARBA:ARBA00008792}.
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DR   RefSeq; XP_016040422.1; XM_016184936.1.
DR   AlphaFoldDB; A0A1S3W2A0; -.
DR   GeneID; 103128845; -.
DR   CTD; 57647; -.
DR   eggNOG; KOG0926; Eukaryota.
DR   InParanoid; A0A1S3W2A0; -.
DR   OrthoDB; 5490433at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd17982; DEXHc_DHX37; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|RefSeq:XP_016040422.1};
KW   Hydrolase {ECO:0000313|RefSeq:XP_016040422.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          255..422
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          517..709
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..521
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          535..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..220
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..508
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..566
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1150 AA;  128801 MW;  C6561E20B0F2124B CRC64;
     MGRLRKRYNF KGRQQAAPDP GKGPPEPPPV RLELEEKDAL KGVDASNALV LPGKKKKKAR
     APPPSKKEKK PLTKKERKML QKVLEQKEKK SQRAEMLQKL NEVQVSETEM KLFYTTSKLG
     TGDRMYHVRE KLSEVVAQDQ KINSLSGAGR KRHRLESEEE ELESSGESEP DQAPTTEIVQ
     QQGPAVHVSP AVGDDSPVPS ALPTPAEPPR PPPAAGPTLA RPPTKPAIFI PVNRTPEMQE
     ERLKLPILAE EQAIMEAVAE HPIIIVCGET GSGKTTQVPQ FLYEAGYSSE NSIIGVTEPR
     RVAAMAMSQR VAKEMNLSHR VVSYQIRYEG NVTEETRIKF MTDGVLLKEI QKDFLLLKYK
     VVIIDEAHER SVYTDILIGL LSRIVMLRAK RHLPLKLLIM SATLRVEDFT QNQRLFAKPP
     PVIKVESRQF PVTVHFNKRT PLDDYSGECF RKVCKIHRML PAGGILVFLT GQAEVHAMCR
     RLRKAFPHTR HKPPEEDDQK DSAKEMRKFK KSRTRARKAQ AVTALPQISL DNYSVLPVGE
     GDEDREAEMD DEEDALGSDL DLDLGDGGED TGGQPDASLP MHVLPLYSLL APEKQAQVFK
     PPPEGTRLCV VATNVAETSL TIPGIKYVVD CGKVKKRYYD RVTGVSSFRV TWVSQASADQ
     RAGRAGRTEP GHCYRLYSSA VFGDFEQFPP PEITRRPVED LILQMKALNI EKVINFPFPT
     PPSVEALVAA EELLIALGAL QAPQKSGRMK QLQSAQLSCP ITELGRTMAT FPVAPRYAKM
     LALSRQHDCL PYAITIVAAM TVRELFEELD RPASSDEELA QLKSQRARVA QMRRIWAGQG
     ASLKLGDIMV MLGAVGACEY SGCSPQFCEA NGLRYKAMLE IRRLRGQLTT AVNAVCPEAG
     LFVDPKMQPP SEIQVTYLRQ IVTAGLGDHL ARRVQSEELL DDKWRNAYKT PLLNDPVFIH
     PSSVLFKELP EFVVYQEIVE TTKMYMKGVS TVEIQWIPAL LPSYCQFDKP LEEPPPSFCP
     DTGRVLCHRA SVFYRVSWPL PTIQVDFPEG IDCYKHFARF LLEGQVFCKL ASYKSCLLSS
     PNTMLKTWAR LQPRTESLLK ALVAEQACSR DTLLAAWKKD PKYLLAEYCE WLPQAMHSDV
     EKAWPPTGNR
//
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