ID A0A1S3W2A0_ERIEU Unreviewed; 1150 AA.
AC A0A1S3W2A0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX37 {ECO:0000313|RefSeq:XP_016040422.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016040422.1};
RN [1] {ECO:0000313|RefSeq:XP_016040422.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR RefSeq; XP_016040422.1; XM_016184936.1.
DR AlphaFoldDB; A0A1S3W2A0; -.
DR GeneID; 103128845; -.
DR CTD; 57647; -.
DR eggNOG; KOG0926; Eukaryota.
DR InParanoid; A0A1S3W2A0; -.
DR OrthoDB; 5490433at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|RefSeq:XP_016040422.1};
KW Hydrolase {ECO:0000313|RefSeq:XP_016040422.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 255..422
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 517..709
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..220
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..566
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1150 AA; 128801 MW; C6561E20B0F2124B CRC64;
MGRLRKRYNF KGRQQAAPDP GKGPPEPPPV RLELEEKDAL KGVDASNALV LPGKKKKKAR
APPPSKKEKK PLTKKERKML QKVLEQKEKK SQRAEMLQKL NEVQVSETEM KLFYTTSKLG
TGDRMYHVRE KLSEVVAQDQ KINSLSGAGR KRHRLESEEE ELESSGESEP DQAPTTEIVQ
QQGPAVHVSP AVGDDSPVPS ALPTPAEPPR PPPAAGPTLA RPPTKPAIFI PVNRTPEMQE
ERLKLPILAE EQAIMEAVAE HPIIIVCGET GSGKTTQVPQ FLYEAGYSSE NSIIGVTEPR
RVAAMAMSQR VAKEMNLSHR VVSYQIRYEG NVTEETRIKF MTDGVLLKEI QKDFLLLKYK
VVIIDEAHER SVYTDILIGL LSRIVMLRAK RHLPLKLLIM SATLRVEDFT QNQRLFAKPP
PVIKVESRQF PVTVHFNKRT PLDDYSGECF RKVCKIHRML PAGGILVFLT GQAEVHAMCR
RLRKAFPHTR HKPPEEDDQK DSAKEMRKFK KSRTRARKAQ AVTALPQISL DNYSVLPVGE
GDEDREAEMD DEEDALGSDL DLDLGDGGED TGGQPDASLP MHVLPLYSLL APEKQAQVFK
PPPEGTRLCV VATNVAETSL TIPGIKYVVD CGKVKKRYYD RVTGVSSFRV TWVSQASADQ
RAGRAGRTEP GHCYRLYSSA VFGDFEQFPP PEITRRPVED LILQMKALNI EKVINFPFPT
PPSVEALVAA EELLIALGAL QAPQKSGRMK QLQSAQLSCP ITELGRTMAT FPVAPRYAKM
LALSRQHDCL PYAITIVAAM TVRELFEELD RPASSDEELA QLKSQRARVA QMRRIWAGQG
ASLKLGDIMV MLGAVGACEY SGCSPQFCEA NGLRYKAMLE IRRLRGQLTT AVNAVCPEAG
LFVDPKMQPP SEIQVTYLRQ IVTAGLGDHL ARRVQSEELL DDKWRNAYKT PLLNDPVFIH
PSSVLFKELP EFVVYQEIVE TTKMYMKGVS TVEIQWIPAL LPSYCQFDKP LEEPPPSFCP
DTGRVLCHRA SVFYRVSWPL PTIQVDFPEG IDCYKHFARF LLEGQVFCKL ASYKSCLLSS
PNTMLKTWAR LQPRTESLLK ALVAEQACSR DTLLAAWKKD PKYLLAEYCE WLPQAMHSDV
EKAWPPTGNR
//