ID A0A1S3W516_ERIEU Unreviewed; 2445 AA.
AC A0A1S3W516;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ubiquitin carboxyl-terminal hydrolase 24 isoform X2 {ECO:0000313|RefSeq:XP_016041465.1};
GN Name=USP24 {ECO:0000313|RefSeq:XP_016041465.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016041465.1};
RN [1] {ECO:0000313|RefSeq:XP_016041465.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016041465.1; XM_016185979.1.
DR GeneID; 103109024; -.
DR CTD; 23358; -.
DR OrthoDB; 6206at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02659; peptidase_C19C; 1.
DR CDD; cd17065; Ubl_UBP24; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR047061; UBP24_Ubl.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF729; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 24; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|RefSeq:XP_016041465.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 1514..1867
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 859..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1746..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1888..1915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2400..2445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2400..2425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2445 AA; 276219 MW; 22385C74FAF36D73 CRC64;
MDRCMPEAFK KLLTSSAVHK WGTEIHEGIY NMLMLLIELV AERIKQDPIP VGLLGVLTMA
FNPDNEYHFK NRMKVSQRNW AEVFGEGNMF AISPVSTFQK EPHGWVVDLV NKFGELGGFA
AIQAKLHSED IELGAVSALV QPLGVCAEYL NSSVVQPMLD PVILTTIQDV RSVEEKDLKD
KRLVSIPELL SATKLLCMRF QPDLVTVVDD LRLDILLRML KSPHFSAKMN SLKEVTKLIE
DSTLSKSVKN AIDTDRLLDW LVENSVLSIA LEGNIDQAQY CDRIKGIIEL LGSKLSLDEL
TKIWKIQSGQ SSTVIENIHT IIAAAAVKFN SDQLNHLFVL IQKSWETESD RVRQKLLSLI
GRIGREARFE TTSGKVLDVL WELAHLPTLP SSLIQQALEE HLTILSDAYA VKEAIKRSYI
IKCIEDIKRP GEWSSLEKNK KDGFKSSQLN NPQFVWVVPA LRQLHEITRS FIKQTCQKQD
KSIIQDLKKN FEIVKLVTGS LIACHRLAAA VSGPGGLTGS TLVDGRYTYR EYLEAHLKFL
AFFLQEATLY LGWNRAKEIW ECLVTGQDVC ELDREMCFEW FTKGQHDLES DVQQQLFKEK
ILKLESYEIT MNGFNLFKTF FENVNLCDHR LKRQGAQLYV EKLELIGMDF IWKIAMESPD
EEIANEAIQL IINYSYINLN PRLKKDSVSL HKKFIADCYT RLEAASSALG GPTLTHAVTR
ATKMLTATAM PTVATSVQSP YRSTKLVIIE RLLLLAERYV ITIEDFYSVP RTILPHGASF
HGHLLTLNVT YESTKDTFTV EAHSNETIGS VRWKIAKQLC CPVDNIQIFT NDSLLTVNKD
QKLLHQLGFS DEQILTVKTS GSGTPSGSSA DSSTSSSSSS SGVFSSSYAM EQEKSLPGVV
MALVCNVFDM LYQLANLEEP RITLRVRKLL LLIPTDPAIQ EALDQLDSLG RKKTLLSETS
SQSSKSPSLS SKQQHQPSAS SILESLFRSF APGMSTFRVL YNLEVLSSKL MPTADDDMAR
SCAKSFCENF LKAGGLSLVV NVMQRDSIPS EVDYETRQGV YSICLQLARF LLVGQTMPTL
LDEDLTKDGI EALSSRPFRN VSRQTSRQMS LCGTPEKSSY RQLSVSDRSS IRVEEIIPAA
RVAIQTMEVS DFTSTVACFM RLSWAAAAGR LDLVGSSQPI KESNSLFPAG IRNRLSSSGS
NCSSGSEGDP VALHAGICVR QQSVSTKDSL IAGEALSLLV TCLQLRSQQL ASFYNLPCVA
DFIIDILLGS PSAEIRRVAC DQLYTLSQTD TSTHPDVQKP NQFLLGVILT AQLPLWSPTS
IMRGVNQRLL SQCMEYFDLR CQLLDDLTTS EMEQLRISPA TMLEDEITWL DNFEPNRTAE
CETSEADNIL LAGHLRLIKT LLSLCGAEKE MLGSSLIKPL LDDFLFRASR IILNSHSPAG
SAAISQQDFH PKCSTVNSRL AAYEVLVMLA DSSPSNLQII TKELLSMHHQ PDPALTKEFD
YLPPVDSRSS SGFVGLRNGG ATCYMNAVFQ QLYMQPGLPE SLLSVEDDTD NPDDSVFYQV
QSLFGHLMES KLQYYVPENF WKIFKMWNKE LYVREQQDAY EFFTSLIDQM DEYLKKMGRD
QIFKNTFQGI YSDQKICKDC PHRYEREEAF MALNLGVTSC QSLEISLDQF VRGEVLEGSN
AYYCEKCKEK RITVKRTCIK SLPSVLVIHL MRFGFDWESG RSIKYDEQIR FPWMLNMEPY
TVSGMARQDS SSEVGENGRS MDQGGGGSPR KKVALTENYE LVGVIVHSGQ AHAGHYYSFI
KDRRGCGKGK WYKFNDTVIE EYDLNDETLE YECFGGEYRP KVYDQTNPYT DVRRRYWNAY
MLFYQRVSDQ NSPVLPKKSR VSVVRQEAED LSLSAPSSPE ISPQSSPRPH RPNNDRLSIL
TKLVKKGEKK GLFVEKMPVR IYQMVRDENL KFMKNRDVYS SDYFSFVLSL ASLNATKLKH
PYYPCMAKVS LQLAIQFLFQ TYLRTKKKLR VDTEEWIATI EALLSKSFDA CQWLVEYFIS
SEGRELIKIF LLECNVREVR VAVATILEKT LDSALFYQDK LKNLHQLLEV LLALLDKDVP
ENCKNCAQYF FLFNTFVQKQ GIRAGDLLLR HSALRHMISF LLGVSRQNNQ IRRWSSAQAR
EFGNLHNTVA LLVLHSDVSS QRNVAPGVFK QRPPISIAPS SPLLPLHEEV EALLFLSEGK
PYLLEVMFAL RELTGSLLAL IEMVVYCCFC NEHFSFTMLH FIKNQLETAP PHELKNTFQL
LHEILVIEDP IQVERVKFVF ETENGLLALM HHSNHVDSSR CYQCVKFLVT LAQKCPAAKE
YFKENSHHWS WAVQWLQKKM SEHYWTPQSN VSNETSTGKT FQRTISAQDT LAYATALLNE
KEQSGSSNGS ESSPANENGE RHLQQGSESP MMIGELRSDL DDVDP
//
