ID A0A1S3W523_ERIEU Unreviewed; 1391 AA.
AC A0A1S3W523;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRM {ECO:0000313|RefSeq:XP_016041059.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016041059.1};
RN [1] {ECO:0000313|RefSeq:XP_016041059.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_016041059.1; XM_016185573.1.
DR CTD; 5797; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14633; R-PTPc-M-1; 1.
DR CDD; cd14635; R-PTPc-M-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045911; R-PTP-mu_cat_rpt1.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF12; PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, M; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_016041059.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 682..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..123
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 125..216
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 223..318
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 321..419
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 421..526
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 839..1093
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1010..1084
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1125..1387
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1301..1378
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1391 AA; 157258 MW; 109F2F0D828E132E CRC64;
MMPPGSFMMV NTSGRPEGQR THLLLPQLKE NDTHCIDFHY FVSSKSNSVP GLLNVYVKVN
NGPLGNSIWN ISGDPNRTWN RAELAISTFW PNFYQVIFEV ITSGHQGYIA IDEVKVLGHP
CTRTPHFLRI QNVEVNAGQF ATFQCSAIGR TVASDSLWLQ GIDVRDTPLK ETKVTNSRRF
IASFNIVNTT KRDAGKYRCM IRTEGGVGIS NYAELVVKEP PVPIAPPQLA SVGATYLWIQ
LNANSINGDG PIVAREVEYC TASGSWNDRQ PVDSTSYKIG HLDPDTEYEI SVLLTRPGEG
GTGSPGPALR TRTKCADPMR GPRKLEVVEV KSRQITIRWE PFGYNVTRCH SYNLTVHYCY
QVGGQEQVRE EVSWDTDSSH PQHTITNLSP YTNVSVKLIL MNPEGRKESR ELIVQTDEDL
PGAVPTESIQ GSTFEEKIFL QWREPIQTYG IITLYEITYK AVSSFDPEID LSNQSGRVSK
LGNETHFLFF GLYPGTTYSF TIRASTAKGF GPPATNQFTT KISAPSMPVY ELEAPLNQTD
NTVTVLLKPA HSRGAPVSVY QIVVEEERPR RTKKTTEILK CYPVPIHFQN ASVLNSQYYF
AAEFPANSLQ AAQPFTIGDN KTYSGYWNTP LLPHKSYRIY FQAASRANGE TKIDCVRVAT
KGAATPKPVP EPEKQTDHTV KIAGVIAGIL LFVIIFLGVV LVMKKRKLAK KRKETMSSTR
QEMTVMVNSM DKSYAEQGTS CDEAFSFMDT HNLNGRSVSS PSSFTMKTNT LSTSVPNSYY
PDETHTMASD TSSLVQSHTY KKREPADVPY QTGQLHPAIR VADLLQHITQ MKCAEGYGFK
EEYESFFEGQ SAPWDSAKKD ENRMKNRYGN IIAYDHSRVR LQTLEGDTNS DYINGNYIDG
YHRPNHYIAT QGPMQETIYD FWRMVWHENT ASIVMVTNLV EVGRVKCCKY WPDDTEIYKD
IKVTLIETEL LAEYVIRTFA VEKRGVHEIR EIRQFHFTGW PDHGVPYHAT GLLGFVRQVK
SKSPPNAGPL VVHCSAGAGR TGCFIVIDIM LDMAEREGVV DIYNCVRELR SRRVNMVQTE
EQYVFIHDAI LEACLCGDTS VPASQVRSLY YDMNKLDPQT NSSQIKEEFR TLNMVTPTLR
VEDCSIALLP RNHEKNRCMD ILPPDRCLPF LITIDGESSN YINAALMDSY KQPSAFIVTQ
HPLPNTVKDF WRLVLDYHCT SVVMLNDVDP AQLCPQYWPE NGVHRHGPIQ VEFVSADLEE
DIISRIFRIY NAARPQDGYR MVQQFQFLGW PMYRDTPVSK RSFLKLIRQV DKWQEEYNGG
EGRTVVHCLN GGGRSGTFCA ISIVCEMLRH QRTVDVFHAV KTLRNNKPNM VDLLDQYKFC
YEVALEYLNS G
//
