ID A0A1S3W5G5_ERIEU Unreviewed; 741 AA.
AC A0A1S3W5G5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=N-acetylated-alpha-linked acidic dipeptidase-like protein {ECO:0000313|RefSeq:XP_016041728.1};
GN Name=NAALADL1 {ECO:0000313|RefSeq:XP_016041728.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016041728.1};
RN [1] {ECO:0000313|RefSeq:XP_016041728.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR RefSeq; XP_016041728.1; XM_016186242.1.
DR AlphaFoldDB; A0A1S3W5G5; -.
DR STRING; 9365.ENSEEUP00000001630; -.
DR GeneID; 103109504; -.
DR CTD; 10004; -.
DR eggNOG; KOG2195; Eukaryota.
DR InParanoid; A0A1S3W5G5; -.
DR OrthoDB; 2428249at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF50; AMINOPEPTIDASE NAALADL1; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 164..249
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 349..557
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 617..735
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 741 AA; 80197 MW; DECF0E6ECDF1F09D CRC64;
MQWVKVLGGV LGGAALLGLG IILGHFAIPK KPTTASSKEA QDLDLKLLES VLGQLDANRI
RDNLRELARA PHLATSPRDE ELVQLLLQRW EDPKSGLDVA VAPQYQVLLS FPDTQPNSVS
VVSPSGEILF SCRQSEENLT GEQGGSEVVR PYAAYAPPGT PQGLLIYANR GSEDDFKELQ
AQGINLTNTI ALTRYGGVGR GAKAINAAKF GVSAVLVYTD PADINDGKSL PNETFPHSWG
LPPSGVERGS YYERFGDPLT PYLPASPSSF RLEPSTVSGF PPIPTQPIGF GDAQELLCNL
QGSVAPAAWQ GALGCEYKLG PGFQPGGNFK DSQVNVSVHN RLELKNSSNV LGIIRGAVEP
DRYVLYGNHR DSWVHGAVDP SSGTAVLLEI SRVLGTLLKK GTWRPRRSIV FASWGAEEFG
LIGSTEFTEE FFSTLQERAV AYINVDISVF ANATLRVQGT PPVQSVVFSA AKQITAPGPN
KLSVYDNWIR YFNRTSPVYG SIPSLGTLGA GSDYAPFLHF LGITSMDIAY TYDRSKTSAR
IYPTYHTAFD TFGYVDKFVD PGFSSHQAVA RMAGSVLLRL SDSLFLPLSV VDYNETLHNF
LRAAQQDLAA LLEQRGISLG PLVTAVEKFE KAAAALNQRI SELQKSQPNP LQVRMLNDQL
MLLERAFLNT RAFPEELYYS HVLWAPRTGP VVTFPGLANA CARATSAGSG PAEWAEVHRQ
LSIIVVALEG ATATLTSVTD L
//