ID A0A1S3W5N2_ERIEU Unreviewed; 648 AA.
AC A0A1S3W5N2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Carnitine O-palmitoyltransferase 1, liver isoform {ECO:0000313|RefSeq:XP_016041675.1};
GN Name=CPT1A {ECO:0000313|RefSeq:XP_016041675.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016041675.1};
RN [1] {ECO:0000313|RefSeq:XP_016041675.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016041675.1; XM_016186189.1.
DR AlphaFoldDB; A0A1S3W5N2; -.
DR eggNOG; KOG3716; Eukaryota.
DR InParanoid; A0A1S3W5N2; -.
DR OrthoDB; 1429709at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 2.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF74; CARNITINE O-PALMITOYLTRANSFERASE 1, LIVER ISOFORM; 1.
DR Pfam; PF00755; Carn_acyltransf; 3.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..47
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 174..310
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT DOMAIN 313..448
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT DOMAIN 495..627
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 396
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 648 AA; 73478 MW; 24FDC5F44F28A22B CRC64;
MAEAHQAVAF QFTVTPDGID LRLSHEALKQ IYLSGLHSWK KKFIRFKNGI ITGVYPASPS
SWLIVVVGVM STMYVKVDPS LGMIARISRT LDATGSMSSQ TRQVASGVLF GTGLWVALIV
SMRYSLKVLL SYHGWMFAEH GRMSRATRIW MAMVKVFSGR KPMLYSFQTS LPRLPVPPVR
DTVSRYLESV KPLMKESDFK RMTVLAQDFA VNLGPRLQWY LKLKSWWATN YVSDWWEEYV
YLRGRGPLMV NSNYYAMAAR AGNTIHAILQ YRRKLDREEI KPIRLLGSTI PLCSAQWERM
FNTSRIPGEE SVPWAKCRQA HFARGKNKQS LDAVEKAAFF VTLDETEQGY RQEDPVTSMD
SYAKSLLHGR CYDRWFDKSF TFIVFKNGKI GLNAEHSWAD APIVGHLWEY VMSTDCFQLG
YTEDGHCKGD INQNIPAPTR LQWDIPEAQE SGDGQGSPAP CQLPRSPTYV SAPSLWGLLG
LSLWFGRCSC PLSATQVEQR LKLFKLASEK HQHLYRLAMT GSGIDRHLFC LYVVSKYLAV
DSPFLKEVLS EPWRLSTSQT PQQQVELFDL ERNPQYVSSG GGFGPVADDG YGVSYILVGE
NLINFHISSK FSCPETDSHR FGQHLKEAMR DIITLFSFSP NSCPNSKK
//
