ID A0A1S3W5Z6_ERIEU Unreviewed; 650 AA.
AC A0A1S3W5Z6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN Name=SSH3 {ECO:0000313|RefSeq:XP_016041752.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016041752.1};
RN [1] {ECO:0000313|RefSeq:XP_016041752.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000256|ARBA:ARBA00009580}.
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DR RefSeq; XP_016041752.1; XM_016186266.1.
DR AlphaFoldDB; A0A1S3W5Z6; -.
DR CTD; 54961; -.
DR eggNOG; KOG1716; Eukaryota.
DR InParanoid; A0A1S3W5Z6; -.
DR OrthoDB; 5490735at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR CDD; cd14571; DSP_slingshot_3; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR014876; DEK_C.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR043587; Phosphatase_SSH-like.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR45864:SF4; PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 3; 1.
DR PANTHER; PTHR45864; SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG; 1.
DR Pfam; PF08766; DEK_C; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF109715; DEK C-terminal domain; 1.
DR PROSITE; PS51998; DEK_C; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 265..320
FT /note="DEK-C"
FT /evidence="ECO:0000259|PROSITE:PS51998"
FT DOMAIN 324..465
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 389..444
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..502
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 71493 MW; 27575C150E94E8E5 CRC64;
MALVTVSRSP PASGHATPVE RPDWAAKRRG RLQRRQSFAV LRGTVLGLQD SGDEGDVAEA
GPEPAGAPLG EDQPPGAQLD SEPGEQKDEQ EQEQSRHLRL MVQLLRPQDD IRLAAQLEAA
RPPRLRYLLV VSPSDSQDET VLLGVDFPDS RSPSCTLGLV LPLWSDTQVY LDGDGGFSVT
SGGQSRIFKP ISIQTMWATL QVLHQACEAA LGSGLVPGGS ALTWAGHYQD QLSSNRSCLN
EWTAMADLES LRPPSTEPGR PSEQEQMEEA IRAGLWEVLE VSDLDSVTSK EIRQALERRL
GYPLQRSRDF IDNQMLLLMA QRDRASMIFP HLYLGSEWNA ANLEELQRNR VSHILNMARE
IDNFFPERFI YHNVRVWDDE AAQLLPCWKE THRFVEAARA QGTRVLVHCK MGVSRSAATV
VAYAMKQYGW SLEQAQRHVQ ERRPVVRPNP GFLRQLQTYQ GILTASRQSQ VWEQKVGAAS
PEEPLAPEVS ALLPPPPPEP GDTGEAKAVE LEESQTAPQE EPGSRPRINL RGVMRSISLL
EPPLELESDP EASNLPEVFS SEPSDGSPPQ TLPLPTQAKC GRQPRKGPWP ALKSRQSVVA
LNSAALVASR TRAFREQEQG QGGAGGVSTS RLRKVVRQAG MEGGTEEGGA
//
