ID   A0A1S3W637_ERIEU        Unreviewed;       185 AA.
AC   A0A1S3W637;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Deoxyguanosine kinase, mitochondrial isoform X5 {ECO:0000313|RefSeq:XP_016041830.1};
GN   Name=DGUOK {ECO:0000313|RefSeq:XP_016041830.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016041830.1};
RN   [1] {ECO:0000313|RefSeq:XP_016041830.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DCK/DGK family.
CC       {ECO:0000256|ARBA:ARBA00007420}.
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DR   RefSeq; XP_016041830.1; XM_016186344.1.
DR   AlphaFoldDB; A0A1S3W637; -.
DR   CTD; 1716; -.
DR   OrthoDB; 315858at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR002624; DCK/DGK.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10513:SF8; DEOXYGUANOSINE KINASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000705; DNK; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Kinase {ECO:0000313|RefSeq:XP_016041830.1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Transferase {ECO:0000313|RefSeq:XP_016041830.1}.
FT   DOMAIN          41..146
FT                   /note="Deoxynucleoside kinase"
FT                   /evidence="ECO:0000259|Pfam:PF01712"
FT   ACT_SITE        141
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT   BINDING         45..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ   SEQUENCE   185 AA;  21151 MW;  B68DE7AD0E9FE6B9 CRC64;
     MVGGRLFWGL LRKLFNSMAQ RPLEGVHLSR GLHAECGLRR LSIEGNIAVG KSTFVKLLTK
     TYPEWHIATE PVATWQNVQT SGTQKACATQ SLGNLLDMLY REPARWSYTF QTFSFLSRLK
     VQLESFPEKY LQTTKAVQIF ERSVPHSESL LNTPVLVLDV NDDFSEEVTR QEELMKKVNT
     FVKNL
//