ID A0A1S3W767_ERIEU Unreviewed; 115 AA.
AC A0A1S3W767;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Platelet factor 4 {ECO:0000256|ARBA:ARBA00040890};
DE AltName: Full=C-X-C motif chemokine 4 {ECO:0000256|ARBA:ARBA00042425};
GN Name=LOC103110670 {ECO:0000313|RefSeq:XP_016042221.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016042221.1};
RN [1] {ECO:0000313|RefSeq:XP_016042221.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000256|ARBA:ARBA00010665}.
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DR RefSeq; XP_016042221.1; XM_016186735.1.
DR AlphaFoldDB; A0A1S3W767; -.
DR eggNOG; ENOG502TF57; Eukaryota.
DR InParanoid; A0A1S3W767; -.
DR OrthoDB; 4170999at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00273; Chemokine_CXC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF199; PLATELET FACTOR 4; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00436; INTERLEUKIN8.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..115
FT /note="Platelet factor 4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010295663"
FT DOMAIN 52..112
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 115 AA; 12257 MW; 1199430278C28D3E CRC64;
MALRAGSSAS CSQPISGLLL WGLLFLSASM AFSTASAASA PLPGDLEEGD GNPHCLCPET
TSRVRFKRIS SLEVIRASLY CPSPQLIATL KNGLKICVDP KATLYKKIIK KIFES
//
