ID A0A1S3W7G4_ERIEU Unreviewed; 1043 AA.
AC A0A1S3W7G4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Protein transport protein Sec24A isoform X3 {ECO:0000313|RefSeq:XP_016042267.1};
GN Name=SEC24A {ECO:0000313|RefSeq:XP_016042267.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016042267.1};
RN [1] {ECO:0000313|RefSeq:XP_016042267.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR RefSeq; XP_016042267.1; XM_016186781.1.
DR AlphaFoldDB; A0A1S3W7G4; -.
DR GeneID; 103110730; -.
DR CTD; 10802; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF1; PROTEIN TRANSPORT PROTEIN SEC24A; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 378..414
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 451..689
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 694..778
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 789..889
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 916..989
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 114720 MW; F578065D2F812F43 CRC64;
MFQPGIPASG GAPTGLQAQN GAPPASGSVY TNGPVQNTLM SSQVPVSQEY NSQFPGSYPH
LIPAKTLNPS LGQSNYGGSQ TVYPPLSNYQ GSGQTLSRPP VASNPPTLHS GPVPQIPPPT
SQNPAATPMP SGSYLPGGAG VPPPLNWQFN YSSTGSQTNH SLSVSSQATL AGNTNFTPSR
QYASSGEPSS QNNFIKPGIT SNTNNGSMMT HNSYDEIEGG GFLATPQFTT KNPTMSRNVG
YSYPSLPPGY ENTAPPGTAG VPPPMNYPSG PQPFTQTPLG ANHLTASMSG LSLHPECLRV
TNLLQDRNML PPTPLQPPVP NLHEDLQKLN CNPELFRCTL TSIPQTQALL NKAKLPLGLL
LHPFKDLTQL PVVTSSTIVR CRACRTYINP FVSFLDQRRW KCNLCYRVND VPEEFMYNPL
TRVYGEPHRR PEVQNATVEF MAPSEYMLRP PQPPVYLFVF DVSHNAVETG YLNSVCQSLF
DNLDLLPGNT RTKIGFITFD STIHFYSLQE GLSQPQMLIV SDIEDVFIPM PENLLVNLNE
SKELVQDLLK TLPQMFSKTL ETQSALGPAL QAAFKLMSPT GGRMSVFQTQ LPTLGIGALK
PREEPNQRSS AKDIHLTPST DFYKKLALDC SGQQVAVDLF LLSGQYSDLA SLGCISRYSA
GSVYYYPSYH HQHNPLQVQK LQKELQRYLT RKIGFEAVMR IRCTKGLSIH TFHGNFFVRS
TDLLSLPNVN PDAGYAVQMS VEENLTDTQL VSFQSALLYT SSKGERRIRV HTLCLPVVST
LNEVFLGADV QAISGLLANM AVDRSVTASL SDARDALVNA VIDSLSAFRS SVLSNQQPGL
MVPFSLRLFP LFVLALLKQK SFQTGTNARL DERIFAMCQV KNQPLVYLML TTHPNLYRVD
NLSDEGALNI NDRMIPQPPI LQLSVEKLSR DGAFLMDAGS ALMLWIGKNC GQNFISQVLG
VQSHALIPQT MTNLPVLDTP ESARMTAFIS WLREQRPFFP VLHVIKDESP MRTIFLQNLV
EDRTESALSY YEFLLHVQQQ VNK
//
