ID A0A1S3W7W3_ERIEU Unreviewed; 1341 AA.
AC A0A1S3W7W3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Tensin-1 isoform X4 {ECO:0000313|RefSeq:XP_016042578.1};
GN Name=TNS1 {ECO:0000313|RefSeq:XP_016042578.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_016042578.1};
RN [1] {ECO:0000313|RefSeq:XP_016042578.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
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DR RefSeq; XP_016042578.1; XM_016187092.1.
DR CTD; 7145; -.
DR OrthoDB; 3439226at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR CDD; cd01213; PTB_tensin; 1.
DR CDD; cd09927; SH2_Tensin_like; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035012; Tensin-like_SH2.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR033929; Tensin_PTB.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR45734; TENSIN; 1.
DR PANTHER; PTHR45734:SF3; TENSIN-1; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 4..176
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 181..307
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 1116..1225
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 397..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..447
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1341 AA; 143857 MW; 01CDBCA8D091517D CRC64;
MSVSPPVEDS CELDLVYVTE RIIAVSFSSS ANEDTFRSNL RQVAQMLSSK HGGSYLLFNL
SERRPDITKL HAKVLEFGWP DLHTPALEKI CSVCKAMDTW LNADPHNVVV LHNKGNRGRI
GVVIAAYMHY SNISASADQA LDRFAMKRFY EDKIVPIGQP SQRRYVHYFS GLLSGSIKMN
NKPLFLHHVI MHGIPNFESK GGCRPFLRIY QAMQPVYTSG IYNVQGDSQT SICITIEPGL
LLKGDILLKC YHKKFRSPAR DVIFRVQFHT CAIHDLGVVF GKEDLDDAFR DDRFPEYGKV
EFVFSYGPEK IQGMEHLVNG PSVSVDYNTA DPLIRWDSYD NFNGYREDGM EEVVGHTQGP
LDGSLYAKVK KKDSLQGSPG GVHIQRPVLS ATPNHVEHTL SHCPAGPTQS LHPKSPATAS
STSPAFLPAT HSPPGPQQPP ASIPGLTAQP QLPPKEGTPD PSRTPEEEPL NLEGLVAHRV
AAYNARLQGL GHSVGSRRPP LHRLQDSSLS GGPPDPLVSR APGMPMDTQC HQLERSRPGF
WKSEGWREEL GVQARERQPA EPPAPLRKRA ASDGQYEYHS PEPSSPRSPG VRSPVQCVSP
ELALTIALNP GGRPKEPHLH SYKEAFEEME GTSPASPPPS GVRSPPGLAK TPLSALGLKP
HNPADIVLYS MGEPRSYVES VVRTAVTGPR AQDPESKSFT APTVQAYSHE PPLRNGTLGS
SFVPPSPLST SSPILSAEST SMGSFPSGES SSQGHWTPTQ PYMDPSFRSG SLGQPSPSAQ
RNYQSSSPLP ATGSSGAYSS PDYAFQPFST PDGQARPPFS SAGVHPVPGS PQARHRTVGT
NTPPSPGFGR RALNSGMATP GSPGLSHRQV MGPGAGFHGN VVSSPQSSTV TTPGSPGLAR
HPGVHQSSGL HGSNLVATPG SPNLGRHPGV HQGSLASGLH GSTTPSPGSP SLGRHLGASG
TVVPGSPSLD RHTAYGGHST PEERRPALSR QSSASGYQAP STPSFPVSPA YYPGLSSPAT
SPSPDSAAFR QGSPTPALPE KRRMSMGDRA GSLPNYATIN GKVSSSPVAS GMSSPSGGST
VSFSHTLPDF SKYSMPDNSP ETRAKVKFVQ DTSKYWYKPE ISREQAIALL KDQEPGAFII
RDSHSFRGAY GLAMKVSSPP TTIMQQNKKG DMTHELVRHF LIETGPRGVK LKGCPNEPNF
GSLSALVYQH SIIPLALPCK LVIPNRDPTD DAKDSSGPAN STTDLLKQGA ACNVLFVNSV
DMESLTGPQA ISKATSETLA ADPTPAATIV HFKVSAQGIT LTDNQRKLFF RRHYPLNTVT
FCDLDPQERK WMKTEGGAPA K
//
